Bioactive Marine Drugs and Marine Biomaterials for  Brain Diseases

Grosso, Clara; Valentão, Patrı́cia; Ferreres, Federico; Andrade, Paula B.

doi:10.3390/md12052539

Cited by 30 publications

(26 citation statements)

References 255 publications

(318 reference statements)

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“…[ 195 ]. Moreover, the marine ecosystem is not inexhaustible and there is a supply problem that limits the use of large amount of marine organisms, especially of marine invertebrates [ 196 ]. Therefore, it is necessary to exhaustively extract with large amount of toxic solvents, to recover as much quantity of compounds and as many compounds as possible.…”

Section: Conventional Vs Alternative Extractiomentioning

confidence: 99%

Alternative and Efficient Extraction Methods for Marine-Derived Compounds

et al. 2015

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Marine ecosystems cover more than 70% of the globe’s surface. These habitats are occupied by a great diversity of marine organisms that produce highly structural diverse metabolites as a defense mechanism. In the last decades, these metabolites have been extracted and isolated in order to test them in different bioassays and assess their potential to fight human diseases. Since traditional extraction techniques are both solvent- and time-consuming, this review emphasizes alternative extraction techniques, such as supercritical fluid extraction, pressurized solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, pulsed electric field-assisted extraction, enzyme-assisted extraction, and extraction with switchable solvents and ionic liquids, applied in the search for marine compounds. Only studies published in the 21st century are considered.

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Section: Conventional Vs Alternative Extractiomentioning

confidence: 99%

Alternative and Efficient Extraction Methods for Marine-Derived Compounds

et al. 2015

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“…Marine materia medica (MMM) derived from marine environments possessing distinct drug properties and functions appears to be especially effective when treating difficult diseases, such as cancers, diabetes, cardio-cerebrovascular diseases, immunodeficiency diseases and senile dementia [ 5 , 6 ]. Currently, it has become an important medicinal resource for the development of new drugs used for preventing and treating difficult diseases [ 7 ]. In recent years, the research and development for CMMM is attracting extensive attention in the field of medicine.…”

Section: Introductionmentioning

confidence: 99%

Chinese Marine Materia Medica Resources: Status and Potential

Zhang

Shao

et al. 2016

Marine Drugs

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Chinese marine materia medica (CMMM) is a vital part of traditional Chinese medicine (TCM). Compared with terrestrial TCM, CMMM, derived from specific marine habitats, possesses peculiar chemical components with unique structures reflecting as potent pharmacological activities, distinct drug properties and functions. Nowadays, CMMM appears to be especially effective in treating such difficult diseases as cancers, diabetes, cardio-cerebrovascular diseases, immunodeficiency diseases and senile dementia, and therefore has become an important medicinal resource for the research and development of new drugs. In recent years, such development has attracted wide attention in the field of medicine. In this study, the CMMM resources in China were systematically investigated and evaluated. It was found that the historic experiences of Chinese people using CMMM have continuously accumulated over a period of more than 3600 years, and that the achievements of the research on modern CMMM are especially outstanding. By June 2015, 725 kinds of CMMMs from Chinese coastal sea areas have been identified and recorded, covering 1552 organisms and minerals. More than 3100 traditional prescriptions containing CMMMs have been imparted and inherited. However, the number of CMMMs is less than the 8188 terrestrial TCMs, from more than 12,100 medicinal terrestrial plants, animals and minerals. In the future, the research and development of CMMM should focus on the channel entries (TCM drug properties), compatibility, effective ingredients, acting mechanisms, drug metabolism and quality standard. This study reveals the high potential of CMMM development.

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“…Marine organisms produce a high diversity of structurally unique natural products with a broad spectrum of biological activities, including anti-cancer or antimicrobial effects, and some compounds even show a promising potential of neurotrophic or neuroprotective activity [ 1 , 2 , 3 , 4 ]. Natural products of marine algae, derived from the algae themselves or their bacterial associates, are a focal point in drug discovery programs due to their various biological activities [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Neurotrophins, such as NGF, are important for neuronal survival, development, differentiation, and functional maintenance of neurons in the central and peripheral system [ 17 , 18 , 19 ]. Hence, compounds with neurotrophin-like activities that promote cell survival and induce process outgrowth are promising therapeutic candidates in the treatment of neurodegenerative diseases [ 4 , 17 ], and may enable regenerative processes [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Dimethylsulfoniopropionate Promotes Process Outgrowth in Neural Cells and Exerts Protective Effects against Tropodithietic Acid

2016

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The marine environment harbors a plethora of bioactive substances, including drug candidates of potential value in the field of neuroscience. The present study was undertaken to investigate the effects of dimethylsulfoniopropionate (DMSP), produced by several algae, corals and higher plants, on cells of the mammalian nervous system, i.e., neuronal N2a and OLN-93 cells as model system for nerve cells and glia, respectively. Additionally, the protective capabilities of DMSP were assessed in cells treated with tropodithietic acid (TDA), a marine metabolite produced by several Roseobacter clade bacteria. Both cell lines, N2a and OLN-93, have previously been shown to be a sensitive target for the action of TDA, and cytotoxic effects of TDA have been connected to the induction of oxidative stress. Our data shows that DMSP promotes process outgrowth and microtubule reorganization and bundling, accompanied by an increase in alpha-tubulin acetylation. Furthermore, DMSP was able to prevent the cytotoxic effects exerted by TDA, including the breakdown of the mitochondrial membrane potential, upregulation of heat shock protein Hsp32 and activation of the extracellular signal-regulated kinases 1/2 (ERK1/2). Our study points to the conclusion that DMSP provides an antioxidant defense, not only in algae but also in mammalian neural cells.

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Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases

Cited by 30 publications

References 255 publications

Alternative and Efficient Extraction Methods for Marine-Derived Compounds

Alternative and Efficient Extraction Methods for Marine-Derived Compounds

Chinese Marine Materia Medica Resources: Status and Potential

Dimethylsulfoniopropionate Promotes Process Outgrowth in Neural Cells and Exerts Protective Effects against Tropodithietic Acid

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