Bioactive materials for bone regeneration based on zinc-modified hydroxyapatite

Gutsalova, Anastasiya; Fedorishin, Dmitriy A.; Lytkina, Daria; Kurzina, Irina

doi:10.1016/j.mencom.2021.04.033

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…12,13 According to report, zinc enables bone regeneration via gearing up synthesis of collagens and deposition of minerals under the mechanism adopted by it to increment alkaline phosphatase (ALP), collagen type I (Coll-I), osteocalcin (OCN) and osteopontin (OPN) to impel osteogenic differentiation. 14,15 Furthermore, zinc has also been reported to have an effect not only in the resorption activity of osteoclasts but also in the formation of osteoclasts from macrophages. 16,17 Accordingly, interfusing zinc with bone grafts is constructive for bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Effect of ZnO-doped magnesium phosphate cements on osteogenic differentiation of mBMSCs in vitro

Wang

Shi

Zhao

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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The insufficient osteogenesis of magnesium phosphate cements (MPCs) limits its further application. It is significant to develop a bioactive MPC with osteogenic properties. In this work, MPCs were reinforced by zinc oxide nanoparticles (ZnO-NPs). The composition, microstructure, setting time, compressive strength and degradation of ZnO-NPs/MPCs (ZNMPCs) were evaluated. The results showed that the setting times of MPCs were prolonged from 8.2 to 25.3 min (5.0ZNMPC). The exothermic temperatures were reduced from 45.8 ± 0.4℃ (MPCs) to 39.3 ± 0.5℃ (1.0ZNMPC). The compressive strength of ZNMPC composite cement with 1 wt. % ZnO-NPs (1.0ZNMPC) was the highest (42.9 MPa) among all the composite cements. Furthermore, the ZNMPCs were cultured with mouse bone marrow mesenchymal stem cells (mBMSCs). The results yielded that the ZNMPCs exhibited good cytocompatibility with enhanced differentiation, proliferation, and mineralization on mBMSCs, and it also pronouncedly elevated the expressions of genes and proteins involving osteogenesis. These findings suggested that ZNMPCs could drive the differentiation toward osteogenesis and mineralization of mBMSCs, providing a simple way to the MPC with enhanced osteogenesis for further orthopedic applications.

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Section: Introductionmentioning

confidence: 99%

Effect of ZnO-doped magnesium phosphate cements on osteogenic differentiation of mBMSCs in vitro

Wang

Shi

Zhao

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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“…Zn2+ probably replace up to 20% of the Ca2+ in the HA lattice (Boanini et al, 2010). Since it causes defects in the structure, it makes the lattice more susceptible to disruption (Gutsalova et al, 2021), which makes Zn-doped HA less soluble than conventional HA (Osorio et al, 2014;Hu et al, 2012). Zn-doped HA crystals are irregular and form agglomerates, usually in the form of rods (Hu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis

Ran,

Liu,

Gao

et al. 2023

Int. J. Dev. Biol.

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For the past 50 years, hydroxyapatite (HA) has been widely used in bone defect repair because it is the main inorganic component of the mineral phase of a human bone. Extensive preclinical and clinical studies have shown that strontium (Sr) can safely and effectively help prevent and treat bone diseases, including osteoporosis. These findings have resulted in the concept of integrating Sr and HA for bone disease management. The doped Sr can improve the physicochemical properties of HA and enhance its angiogenic and bone regeneration ability. Nevertheless, no study has reviewed the design strategy of Sr-doped HA (Sr-HA) to understand its biological roles. Therefore, in this article, we review recent developments in Sr-HA preparation and its effect on osteogenesis and angiogenesis in vitro and in vivo along with key suggestions for future research and development.

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Modified hydroxyapatite as a carrier for 69mZn

et al. 2021

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Sorption of zinc ions and 69m Zn radionuclide proceeds much more rapidly on hydroxyapatite modifi ed with zinc ions (HAP-Zn) than on unmodifi ed HAP. The sorption can be described by a pseudo-second order model and probably follows an exchange mechanism, as evidenced by the transfer of calcium ions into the mother liquor during the process. Sorbed 69m Zn participates in a slow reverse isotope exchange with the solution containing non-radioactive zinc ions.

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Bioactive materials for bone regeneration based on zinc-modified hydroxyapatite

Cited by 6 publications

References 18 publications

Effect of ZnO-doped magnesium phosphate cements on osteogenic differentiation of mBMSCs in vitro

Effect of ZnO-doped magnesium phosphate cements on osteogenic differentiation of mBMSCs in vitro

Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis

Modified hydroxyapatite as a carrier for 69mZn

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