Bioactive Metabolites From Marine Microorganisms

Liu, Xiaohong; Xu, Fang; Shao, Chang‐Lun; She, Zhigang; Lin, Yongcheng; Chan, Wing Lai

doi:10.1016/s1572-5995(08)80007-5

Cited by 9 publications

(6 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Marine microorganisms, including bacteria, fungi, and microalgae, are of considerable importance as promising new sources of a huge number of biologically active products [23,24,25,26]. Some of these marine species live in high-pressure, high-salt, low-temperature, and oligotrophic environments, which provide the opportunity for them to produce unique active substances that differ from the terrestrial ones [27].…”

Section: The Classification and Main Structure Features Of Marine mentioning

confidence: 99%

The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview

2012

View full text Add to dashboard Cite

Recently, the studies on the antiviral activities of marine natural products, especially marine polysaccharides, are attracting more and more attention all over the world. Marine-derived polysaccharides and their lower molecular weight oligosaccharide derivatives have been shown to possess a variety of antiviral activities. This paper will review the recent progress in research on the antiviral activities and the mechanisms of these polysaccharides obtained from marine organisms. In particular, it will provide an update on the antiviral actions of the sulfated polysaccharides derived from marine algae including carrageenans, alginates, and fucans, relating to their structure features and the structure–activity relationships. In addition, the recent findings on the different mechanisms of antiviral actions of marine polysaccharides and their potential for therapeutic application will also be summarized in detail.

show abstract

Section: The Classification and Main Structure Features Of Marine mentioning

confidence: 99%

The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview

2012

View full text Add to dashboard Cite

show abstract

“…Although most known natural products have been obtained from terrestrial environments, 129 bioactive compounds were isolated from marine microbes from 2000 to 2003 [69]. It is clear that the marine environment has yielded many new natural products [58].…”

Section: The Value and Occurrence Of Natural Productsmentioning

confidence: 99%

Importance of microbial natural products and the need to revitalize their discovery

Demain

2014

Journal of Industrial Microbiology and Biotechnology

371

216

View full text Add to dashboard Cite

Microbes are the leading producers of useful natural products. Natural products from microbes and plants make excellent drugs. Significant portions of the microbial genomes are devoted to production of these useful secondary metabolites. A single microbe can make a number of secondary metabolites, as high as 50 compounds. The most useful products include antibiotics, anticancer agents, immunosuppressants, but products for many other applications, e.g., antivirals, anthelmintics, enzyme inhibitors, nutraceuticals, polymers, surfactants, bioherbicides, and vaccines have been commercialized. Unfortunately, due to the decrease in natural product discovery efforts, drug discovery has decreased in the past 20 years. The reasons include excessive costs for clinical trials, too short a window before the products become generics, difficulty in discovery of antibiotics against resistant organisms, and short treatment times by patients for products such as antibiotics. Despite these difficulties, technology to discover new drugs has advanced, e.g., combinatorial chemistry of natural product scaffolds, discoveries in biodiversity, genome mining, and systems biology. Of great help would be government extension of the time before products become generic.

show abstract

“…Although most of the known natural products have been obtained from terrestrial environments, 129 bioactive compounds were isolated from marine microbes from 2000 to 2003. 34 Bacteria occupy up to 40% of the biomass of sponges. 35 Sponges are the most important source of biologically natural products, and the producers are often their bacterial symbionts.…”

Section: The Importance Of Natural Productsmentioning

confidence: 99%

Antibiotics: Natural products essential to human health

Demain

2009

Medicinal Research Reviews

165

View full text Add to dashboard Cite

For more than 50 years, natural products have served us well in combating infectious bacteria and fungi. Microbial and plant secondary metabolites helped to double our life span during the 20th century, reduced pain and suffering, and revolutionized medicine. Most antibiotics are either (i) natural products of microorganisms, (ii) semi-synthetically produced from natural products, or (iii) chemically synthesized based on the structure of the natural products. Production of antibiotics began with penicillin in the late 1940s and proceeded with great success until the 1970-1980s when it became harder and harder to discover new and useful products. Furthermore, resistance development in pathogens became a major problem, which is still with us today. In addition, new pathogens are continually emerging and there are still bacteria that are not eliminated by any antibiotic, e.g., Pseudomonas aeruginosa. In addition to these problems, many of the major pharmaceutical companies have abandoned the antibiotic field, leaving much of the discovery efforts to small companies, new companies, and the biotechnology industries. Despite these problems, development of new antibiotics has continued, albeit at a much lower pace than in the last century. We have seen the (i) appearance of newly discovered antibiotics (e.g., candins), (ii) development of old but unutilized antibiotics (e.g., daptomycin), (iii) production of new semi-synthetic versions of old antibiotics (e.g., glycylcyclines, streptogrammins), as well as the (iv) very useful application of old but underutilized antibiotics (e.g., teicoplanin).

show abstract

Bioactive Metabolites From Marine Microorganisms

Cited by 9 publications

References 217 publications

The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview

The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview

Importance of microbial natural products and the need to revitalize their discovery

Antibiotics: Natural products essential to human health

Contact Info

Product

Resources

About