Bioactive Nanocomposites for Tissue Repair and Regeneration: A Review

Bramhill, Jane; Ross, Sukunya; Ross, Gareth

doi:10.3390/ijerph14010066

Cited by 90 publications

(55 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The different type of hydrocolloid gels with different structural gelation provides the hydrocolloid dressings with an opportunity to exhibit the control of drug release. The amount of drug release can be controlled by optimization of the size of particles and the permeability of the gel membrane (Bramhill et al 2017 ).…”

Section: Hydrocolloidsmentioning

confidence: 99%

Synthetic polymeric biomaterials for wound healing: a review

et al. 2018

View full text Add to dashboard Cite

Wounds are of a variety of types and each category has its own distinctive healing requirements. This realization has spurred the development of a myriad of wound dressings, each with specific characteristics. It is unrealistic to expect a singular dressing to embrace all characteristics that would fulfill generic needs for wound healing. However, each dressing may approach the ideal requirements by deviating from the ‘one size fits all approach’, if it conforms strictly to the specifications of the wound and the patient. Indeed, a functional wound dressing should achieve healing of the wound with minimal time and cost expenditures. This article offers an insight into several different types of polymeric materials clinically used in wound dressings and the events taking place at cellular level, which aid the process of healing, while the biomaterial dressing interacts with the body tissue. Hence, the significance of using synthetic polymer films, foam dressings, hydrocolloids, alginate dressings, and hydrogels has been reviewed, and the properties of these materials that conform to wound-healing requirements have been explored. A special section on bioactive dressings and bioengineered skin substitutes that play an active part in healing process has been re-examined in this work.

show abstract

Section: Hydrocolloidsmentioning

confidence: 99%

Synthetic polymeric biomaterials for wound healing: a review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…And the beneficial effect of magnetic scaffolds on the improvement of cell proliferation and newly formed bone tissue growth has been well documented. The scaffolds have a wide range of components, including biomacromolecules (e. g., collagen, silk fibroin, chitosan), synthetic polymers (e. g., PLA, PLGA, PCL,, polyethylene glycol), inorganic materials (e. g. bioactive glass/glass ceramic,, hydroxyapatite),, and the complexes of components mentioned above. Example studies of magnetic scaffolds for bone tissue engineering and bone regeneration were summarized here.…”

Section: Iopns‐based Composite Bone Scaffoldsmentioning

confidence: 99%

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

et al. 2018

ChemPhysChem

View full text Add to dashboard Cite

The paper provides a brief overview of the use of iron oxide nanoparticles (IONPs) in the areas of bone regenerative medicine. Reconstruction of bone defects caused by trauma, non-union, and bone tumor excision, still faces many challenges despite the intense investigations and advancement in bone-tissue engineering and bone regeneration over the past decades. IONPs have promising prospects in this field due to their controlled responsive characteristics in specific external magnetic fields and have been of great interest during the last few years. This Minireview aims to summarize the relevant progress and describes the following five aspects: (i) The general introduction of IONPs, with a focus on the magnetic properties as the base of application; (ii) using IONPs as tools to study and control stem cells for better treatment efficacy in stem-cell-based bone defect repair; (iii) the use of IONPs and their complexes in the delivery of therapeutic agents, including chemical drug molecules, growth factors, and genetic materials, to promote osteogenesis-related cell function and differentiation, healthy bone tissue growth, and functional reconstruction; (iv) magneto-mechanical actuation in the regulation of cells distribution, mechano-transduction membrane receptors activation, and mechanosensitive signaling pathways regulation, and (v) fabrication, characteristics, and in vitro and in vivo osteogenic effects of magnetic composite bone scaffolds. Ongoing prospects are also discussed.

show abstract

“…[1][2][3][4][5] Furthermore, cellulose is both biocompatible and nontoxic, which additionally promotes its applications in medicine, for example in wound dressings, bone implants and bionanocomposites with antimicrobial activity. [6][7][8][9][10] Despite such a wide range of applications, the impact and interactions of cellulose with cells remain to be fully understood. Here, we focus on the interactions of cellulose with model cellular plasma membranes.…”

Section: Introductionmentioning

confidence: 99%

Phospholipid-Cellulose Interactions: Insight from Atomistic Computer Simulations for Understanding the Impact of Cellulose-Based Materials on Plasma Membranes

Gurtovenko

Mukhamadiarov

Kostritskii

et al. 2018

Preprint

View full text Add to dashboard Cite

Cellulose is an important biocompatible and nontoxic polymer widely used in numerous biomedical applications. The impact of cellulose-based materials on cells and, more specifically, on plasma membranes that surround cells, however, remains poorly understood. To this end, here we performed atomic-scale molecular dynamics (MD) simulations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) bilayers interacting with the surface of a cellulose crystal. Both biased umbrella sampling and unbiased simulations clearly show the existence of strong attractive interactions between phospholipids and cellulose: the free energy of the cellulose-bilayer binding was found to be -1.89 and -1.96 kJ/mol per cellulose dimer for PC and PE bilayers, respectively.Although the values are similar, there is a pronounced difference between PC and PE bilayers. The driving force in both cases is the formation of hydrogen bonds. There are two distinct types of hydrogen bonds: 1) between the lipid head groups and the hydroxyl (hydroxymethyl) groups of cellulose, and 2) lipid-water and cellulose-water bonds. The former is the dominant component for PE systems whereas the latter dominates in PC systems. This suggests that achieving controlled binding via new cellulose modifications must pay close attention to the lipid head groups involved. The observed attractive phospholipid-cellulose interactions have a significant impact on bilayer properties: a cellulose crystal induces noticeable structural perturbations on the bilayer leaflet next to the crystal. Given that such perturbations can be undesirable when it comes to the interactions of cellulose-based materials with cell membranes, our computational studies suggest that the impact of cellulose could be reduced through chemical modification of the cellulose surface which prevents cellulose-phospholipid hydrogen bonding.

show abstract

Bioactive Nanocomposites for Tissue Repair and Regeneration: A Review

Cited by 90 publications

References 131 publications

Synthetic polymeric biomaterials for wound healing: a review

Synthetic polymeric biomaterials for wound healing: a review

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

Phospholipid-Cellulose Interactions: Insight from Atomistic Computer Simulations for Understanding the Impact of Cellulose-Based Materials on Plasma Membranes

Contact Info

Product

Resources

About