Bioactive nanoglasses and xerogels (SiO2–CaO and SiO2–CaO–P2O5) as promising candidates for biomedical applications

Fandzloch, Marzena; Bodylska, Weronika; Augustyniak, Adam W.; Roszek, Katarzyna; Jaromin, Anna; Łukowiak, Anna

doi:10.1016/j.ceramint.2022.10.225

Cited by 8 publications

(6 citation statements)

References 74 publications

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“…To date, still few studies have attempted to quantitatively investigate hydroxyl groups on silica particles. [ 40–43 ] The issue, however, seems quite important because these groups may act as nucleation sites for hydroxyapatite. [ 40 ] Importantly, a greater number of OH ‐ groups on a bioactive glass surface would also increase its hydrophilic properties and thus improve cell adhesion.…”

Section: Resultsmentioning

confidence: 99%

“…[ 40 ] On the other hand, for the nanoparticles of glasses or xerogels obtained solvothermally, we noted the content of OH groups in the range of 29.4–44.2 nm −2 . [ 43 ] It indicates that the sol–gel method provides higher content of hydroxyl group on the bioactive glass surface.…”

Section: Resultsmentioning

confidence: 99%

“…To the best of our knowledge, except for solvothermally derived nanoglass, [ 19 ] 4 h was the shortest apatite mineralization time noted so far for bioactive glass after soaking in phosphate buffer. [ 43,48,49 ] Surprisingly, we recently observed for solvBG76 in a binary system 76SiO 2 –24CaO (wt%) [ 19 ] a time of only 30 min needed for HA to start forming on the glass surface. Therefore, in order to estimate more accurately the beginning of the mineralization process of newly synthesized glasses, an in situ experiment monitored by ATR‐FTIR was carried out ( Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…[40] On the other hand, for the nanoparticles of glasses or xerogels obtained solvothermally, we noted the content of OH groups in the range of 29.4-44.2 nm −2 . [43] It indicates that the sol-gel method provides higher content of hydroxyl group on the bioactive glass surface. The correlation of the porosity and the content of the OH groups can explain why the same amount of CaO precursor could cause four different actual compositions of bioactive glasses.…”

Section: Thermal Analysismentioning

confidence: 99%

“…[56] On the other hand, among the solvothermally synthesized nanoparticles of xerogels and glasses, the highest cell viability of MC3T3 cells at 1000 µg mL −1 was noted at 61% (for solvXG78P6 after 72 h), while for the reference 45S5 glass, 81% was reported. [43]…”

Section: In Vitro Bio-and Hemocompatibilitymentioning

confidence: 99%

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Synthesis and Characterization of Sol–Gel‐Derived SiO₂–CaO Particles: Size Impact on Glass (Bio)Properties

Fandzloch

Bodylska

Roszek

et al. 2023

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increase revascularization, osteoblast adhesion, enzyme activity, and differentiation of mesenchymal stem cells, [2][3][4] thus BGs can be successfully applied in tissue engineering. [5][6][7] These actions are possible due to time-dependent kinetic surface modification of BGs after implantation. [8] And importantly, the surface of bioactive glasses is able to form a biologically active hydroxyl layer of carbonate apatite (HCA) which is chemically and structurally very similar to bone's material, [9] thus enhancing the bone-forming activity.It is possible to control the physicochemical and biological properties of the bioactive glass by adjusting the composition. [10] Factors such as particle size and porosity may also affect the properties of BGs, thus synthesis process is crucial. First known bioactive glass, namely Bioglass 45S5, reported by Larry Hench, was melt-prepared. [11] This method includes a mixture of different precursors in strictly defined proportions, melting temperatures up to 1400 °C and quenching in graphite mold or in water. Melt-quenching method enables the production of bioactive glasses in a scalable way but exhibits few limitations, thus the control of the properties is challenging. Using high temperature provokes an unfavorable crystallization process, [12] moreover, melt-derived BGs usually exhibit irregular shapes and inhomogeneous particle size distribution. [13] The sol−gel method offers an interesting alternative to the melt approach. Obtained at much lower temperatures sol−gel glasses present greater specific surface area and pore volume than melt-derived materials. It is relevant because the surface area of the glass is related to its bioactivity, as it has a direct impact on the glass dissolution and apatite formation. [14] Furthermore, the sol−gel process enables tuning composition and particle size by adjusting factors such as the initial water/ alcohol ratio, type of the precursor or the concentration of the catalyst. [15] Recently, calcium hydroxide (Ca(OH) 2 ) has been used as a calcium source instead of the precursors previously mentioned. [16][17][18][19] It positively affects not only physical but also biological properties. The cell viability of osteoblasts on bioglasses prepared using Ca(OH) 2 was greater than in glasses with conventional precursors. Moreover, it may affect the type of crystalline phase after sintering, which may result in improved mechanical and biological properties of bioactive Four highly bioactive glasses in a binary SiO 2 -CaO system are prepared following a sol−gel method using Ca(OH) 2 as a calcium precursor. In the synthesis of glass according to the modified Stöber method, Ca(OH) 2 suspended in polyethylene glycol allows the elimination of the presence of calcite and the increase of ammonia concentration causes formation of spherical particles with different sizes in the range of 26-266 nm. The relation among the size and properties, including bioactivity, of the glass particles is evaluated. New glasses that vary in composition (10-25 wt% CaO)...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Thermal Analysismentioning

confidence: 99%

Section: In Vitro Bio-and Hemocompatibilitymentioning

confidence: 99%

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Synthesis and Characterization of Sol–Gel‐Derived SiO₂–CaO Particles: Size Impact on Glass (Bio)Properties

Fandzloch

Bodylska

Roszek

et al. 2023

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Synthesis of three-component bioactive glass SiO2– CaO– P2O5 by hydrothermal method using oleic acid as a surfactant

Hoa,

Minh,

Phuc

et al. 2024

J Aust Ceram Soc

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Thermodynamic behavior of bioactive glass in relationship with high fluorine content

Gharbi

Feki

Cheikhrouhou‐Koubaa

et al. 2023

Ceramics International

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Bioactive nanoglasses and xerogels (SiO2–CaO and SiO2–CaO–P2O5) as promising candidates for biomedical applications

Cited by 8 publications

References 74 publications

Synthesis and Characterization of Sol–Gel‐Derived SiO₂–CaO Particles: Size Impact on Glass (Bio)Properties

Synthesis and Characterization of Sol–Gel‐Derived SiO₂–CaO Particles: Size Impact on Glass (Bio)Properties

Synthesis of three-component bioactive glass SiO2– CaO– P2O5 by hydrothermal method using oleic acid as a surfactant

Thermodynamic behavior of bioactive glass in relationship with high fluorine content

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Bioactive nanoglasses and xerogels (SiO2–CaO and SiO2–CaO–P2O5) as promising candidates for biomedical applications

Cited by 8 publications

References 74 publications

Synthesis and Characterization of Sol–Gel‐Derived SiO2–CaO Particles: Size Impact on Glass (Bio)Properties

Synthesis and Characterization of Sol–Gel‐Derived SiO2–CaO Particles: Size Impact on Glass (Bio)Properties

Synthesis of three-component bioactive glass SiO2– CaO– P2O5 by hydrothermal method using oleic acid as a surfactant

Thermodynamic behavior of bioactive glass in relationship with high fluorine content

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Product

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Synthesis and Characterization of Sol–Gel‐Derived SiO₂–CaO Particles: Size Impact on Glass (Bio)Properties

Synthesis and Characterization of Sol–Gel‐Derived SiO₂–CaO Particles: Size Impact on Glass (Bio)Properties