Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases

Abstract

Non-communicable diseases (NCD) are the leading cause of death and disability worldwide. The four main leading causes of NCD are cardiovascular diseases, cancers, respiratory diseases and diabetes. Recognizing the devastating impact of NCD, novel prevention and treatment strategies are extensively sought. Marine organisms are considered as an important source of bioactive peptides that can exert biological functions to prevent and treatment of NCD. Recent pharmacological investigations reported cardio protective, anticancer, antioxidative, anti-diabetic, and anti-obesity effects of marine-derived bioactive peptides. Moreover, there is available evidence supporting the utilization of marine organisms and its bioactive peptides to alleviate NCD. Marine-derived bioactive peptides are alternative sources for synthetic ingredients that can contribute to a consumer’s well-being, as a part of nutraceuticals and functional foods. This contribution focus on the bioactive peptides derived from marine organisms and elaborates its possible prevention and therapeutic roles in NCD.

Insect and fish by-products as sustainable alternatives to conventional animal proteins in animal nutrition

“…Bioactive compounds -The possibility to extract bioactive peptides for pharmaceutical, nutraceutical and cosmeceutical industries is promising, adding great value to this under-used waste. Indeed, anti-inflammatory, immunomodulatory, antimicrobial, antiviral, anticarcinogenic, antioxidant and cardioprotective peptides have been identified in fish by-products (Najafian and Babji 2012;Ahn et al 2015;Chi et al 2015;Nurdiani et al 2017;Pangestuti and Kim 2017) and several companies are interested in investing in this sector (Cheung et al 2015).…”

Bioactive Peptides from Marine Molluscs – A Review

“…Keenamide A, a cyclic hexapeptide, exhibited significant in vitro activity against the lymphocytic leukemia cells (P-388) and human adenocarcinoma cells (A-549) with and IC 50 of 2.5 µg/ml was well as the human colorectal adenocarcinoma tumor cells (HT-29) with an IC 50 of 5.0 µg/ml [29]. A 15 kDa linear peptide designated Mere15 was isolated from Meretrix meretrix [30,31,32]. Mere15 inhibited the growth of K562 leukemia cells in vitro (IC 50 [30,31,32].…”

“…A 15 kDa linear peptide designated Mere15 was isolated from Meretrix meretrix [30,31,32]. Mere15 inhibited the growth of K562 leukemia cells in vitro (IC 50 [30,31,32]. SCH-P9 (Leu-Pro-Gly-Pro) and SCH-P10 (Asp-Tyr-Val-Pro) peptides were obtained from Sinonovacula constricta hydrolysates and demonstrated to inhibit the growth of the prostate cancer cell lines, DU-145 and PC-3, in a doseand time-dependent manner [33].…”

Peptide profile and free radical scavenging activity of the low molecular weight peptide fraction from whole body extracts of <i>Tympanotonus fuscatus</i> var radula (Linnaeus) and <i>Pachymelania aurita</i> (Muller)

“…The numbers of research publications reporting significant bioactivity exerted by high molecular weight proteins are few (Scotti et al, 2001). Furthermore, Lower molecular weight peptides have been demonstrated to possess stronger antioxidant activity compared to the higher molecular weight peptides (Pangestuti et al, 2017) and this may be due to improved contact ability with membrane lipids and/or permeability by the lower molecular weight peptides (Rajapakse et al, 2005;Pangestuti et al, 2017).…”