Bioactive Peptides—Impact in Cancer Therapy

Leo, Edwin E. Martínez; Ortega, Armando M. Martín; Campos, Maira Rubí Segura

doi:10.1016/b978-0-12-814625-5.00009-1

Cited by 3 publications

(5 citation statements)

References 63 publications

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“…The health-promoting effects of bioactive peptides and amino acids have made them stand out as natural and harmless candidates for developing functional foods and nutraceuticals [1][2][3]. Their significance becomes apparent when considering their biological roles in the human body and nutritional value due to their content of essential amino acids [4]. Bioactive peptides and amino acids from marine sources exert a broad spectrum of biological effects on the cardiovascular, immune, nervous, and gastrointestinal systems [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Post-Extraction Ultrasonication on Compositional Features and Antioxidant Activities of Enzymatic/Alkaline Extracts of Palmaria palmata

Ghelichi,

Sørensen,

Hajfathalian

et al. 2024

Marine Drugs

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Palmaria palmata is a viable source of nutrients with bioactive properties. The present study determined the potential role of post-extraction ultrasonication on some compositional features and antioxidant properties of enzymatic/alkaline extracts of P. palmata (EAEP). No significant difference was detected in terms of protein content and recovery, as well as the amino acid composition of the extracts. The nitrogen-to-protein conversion factor of 5 was found to be too high for the seaweed and EAEP. The extracts sonicated by bath for 10 min and not sonicated showed the highest and lowest total phenolic contents (p < 0.05), respectively. The highest radical scavenging and lowest metal-chelating activities were observed for the non-sonicated sample, as evidenced by IC50 values. The extract sonicated by bath for 10 min showed the most favorable in vitro antioxidant properties since its radical scavenging was not significantly different from that of the not-sonicated sample (p > 0.05). In contrast, its metal-chelating activity was significantly higher (p < 0.05). To conclude, post-extraction ultrasonication by an ultrasonic bath for 10 min is recommended to increase phenolic content and improve the antioxidant properties of EAEP.

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Section: Introductionmentioning

confidence: 99%

Effect of Post-Extraction Ultrasonication on Compositional Features and Antioxidant Activities of Enzymatic/Alkaline Extracts of Palmaria palmata

Ghelichi,

Sørensen,

Hajfathalian

et al. 2024

Marine Drugs

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“…The cancer cells have a high ROS and RNS production, which generates lipid oxidation and cell injury . Previous studies have reported that people with cancer have a decreased antioxidant system (glutathione peroxidase and superoxide dismutase at low levels), while presenting a high production of ROS that can be measured in plasma, in contrast to healthy people …”

Section: Introductionmentioning

confidence: 99%

“…Although studies report antioxidant activities in peptides, there is still much to know, mainly regarding the implications in cancer cells. However, the use of certain antioxidant peptides in preventing and treatment of cancer has been suggested . Thus, the current study evaluated the antioxidant and protective effects of PFs derived from M. pruriens L. on HeLa cell line.…”

Section: Introductionmentioning

confidence: 99%

“…12 Previous studies have reported that people with cancer have a decreased antioxidant system (glutathione peroxidase and superoxide dismutase at low levels), while presenting a high production of ROS that can be measured in plasma, in contrast to healthy people. 13,14 Noncommunicable diseases (NCDs) are the principal cause of death worldwide. 15 NCDs are catalogued as complex due to different factors that are involved in their etiology.…”

Section: Introductionmentioning

confidence: 99%

“…However, the use of certain antioxidant peptides in preventing and treatment of cancer has been suggested. 13,16 Thus, the current study evaluated the antioxidant and protective effects of PFs derived from M. pruriens L. on HeLa cell line.…”

Section: Introductionmentioning

confidence: 99%

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Peptides from Mucuna pruriens L., with protection and antioxidant in vitro effect on HeLa cell line

et al. 2019

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BACKGROUND Mucuna pruriens L. is a legume sown in the Mexican southeast with an important protein content. Studies have shown the potential use of by‐products derived from Mucuna as a functional food because of the hypoglycemic and antihypertensive activities. Thus, this study aims to assess the antioxidant and protective effect of the peptide fractions derived from M. pruriens L., in vitro on the HeLa cell line. An enzymatic hydrolysis with pepsin–pancreatin was performed on the total protein concentrate, from which five peptide fractions were obtained. RESULTS All protein derivatives from M. pruriens L., except F5–10 kDa, decreased the hydrogen peroxide production by more than 50%. The highest antioxidant activity was exhibited by F1–3 kDa, which lowered the intracellular reactive oxygen species by 207 ± 4.20%. No significant differences were found in the protective effects of the protein hydrolysate, F5–10 kDa, F3–5 kDa and F1–3 kDa relative to the N‐acetylcysteine control group. CONCLUSION This elucidated the potential action mechanisms of M. pruriens L. protein derivatives for future investigations and their role in the prevention and treatment of oxidative stress. © 2019 Society of Chemical Industry

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Biyoaktif Besin Peptitleri ve Sağlık Üzerine Etkileri

Yalçin¹,

Rakıcıoğlu²

2020

Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Biyoaktif besin peptitleri, vücutta birçok biyolojik işlevin kontrolünde yapısal özelliğe sahiptir. Bu bileşenlerin olumlu etkilerini gösterebilmeleri için fizyolojik olarak gerçekçi düzeyde ve ölçülebilir etki göstermesi gerekmektedir. Biyoaktif peptitler; fizyolojik tepkimelerin indüklenmesine yol açan, hedef hücreler üzerindeki spesifik reseptörlere bağlanma yoluyla fizyolojik fonksiyonu olan, hormon veya ilaç benzeri aktiviteye sahip peptitler olarak tanımlanmıştır. Biyoaktif peptitler genellikle 3-20 amino asit kalıntısı içermekte ve temel protein yapısındayken etkinlik göstermemektedir. Bitki ve hayvan proteinlerinin temel yapısında bulunan biyoaktif besin peptitlerinin etkinlik gösterebilmesi için peptit sekanslarının serbest hale gelmesi gerekmektedir. Bu peptitler çoğunlukla enzimatik hidroliz, gastrointestinal sistemde sindirim enzimleri ile hidroliz ve fermentasyon yoluyla üretilmektedir. Yapılan in vitro ve in vivo çalışmalarda; biyoaktif besin peptitlerinin antihipertansif, hipolipidemik, antioksidan, antiinflamatuar aktiviteye sahip olduğu bildirilmiştir. Bu nedenle, son yıllarda kronik hastalıkların önlenmesinde, tedavisinde ve genel sağlığın korunmasında biyoaktif besin peptitlerin kullanımına yönelik çalışmalar artmaktadır. Bu derleme yazının amacı, biyoaktif besin peptitlerini ve sağlık üzerine olan etkilerinin değerlendirilmesidir.

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Bioactive Peptides—Impact in Cancer Therapy

Cited by 3 publications

References 63 publications

Effect of Post-Extraction Ultrasonication on Compositional Features and Antioxidant Activities of Enzymatic/Alkaline Extracts of Palmaria palmata

Effect of Post-Extraction Ultrasonication on Compositional Features and Antioxidant Activities of Enzymatic/Alkaline Extracts of Palmaria palmata

Peptides from Mucuna pruriens L., with protection and antioxidant in vitro effect on HeLa cell line

Biyoaktif Besin Peptitleri ve Sağlık Üzerine Etkileri

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