Bioactive polymers 65—studies of cross-linked xanthan hydrogels as supports in drug retardation

Dumitriu, Severian; Dumitriu, Maria; Teaca, Gabriela

doi:10.1016/0267-6605(90)90063-2

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Xanthan was used for a re‐epithelializing agent and pharmaceutical formulation, eventually mixed with hyaluronic acid; this material improves the formation of newly grown epithelium 538. For some applications, xanthan was crosslinked with epichlorohydrin539 or complexed with chitosan 540–542. For covalent crosslinked xanthan the release occurs by diffusion; the electrostatic complex shows good biocompatibility and no cytotoxic effects; and the complex formation seems to give a better control of the degradation kinetics.…”

Section: Microbial Polysaccharidesmentioning

confidence: 99%

Main properties and current applications of some polysaccharides as biomaterials

Rinaudo

2007

Polymer International

877

537

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This review concerns the applications of some polysaccharides in the domain of biomaterials and bioactive polymers. Natural polysaccharides from different sources have been studied for a long time, and their main properties are summarized in this paper; some of their derivatives obtained by chemical modification are also described. The main polysaccharides currently used in the biomedical and pharmaceutical domains are chitin and its derivative chitosan, hyaluronan and alginates. Alginates are well known for their property of forming a physical gel in the presence of divalent counterions (Ca, Ba, Sr) whereas carrageenans form a thermoreversible gel; these seaweed polysaccharides are mainly used to encapsulate different materials (cells, bacteria, fungi). Other promising systems are the electrostatic complexes formed when an anionic polysaccharide is mixed with a cationic polysaccharide (e.g. alginate/chitosan or hyaluronan/chitosan). An important development of the applications of polysaccharides can be predicted for the next few years in relation to their intrinsic properties such as biocompatibility and biodegradability in the human body for some of them; they are also renewable and have interesting physical properties (film‐forming, gelling and thickening properties). In addition, they are easily processed in different forms such as beads, films, capsules and fibres. Copyright © 2007 Society of Chemical Industry

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Section: Microbial Polysaccharidesmentioning

confidence: 99%

Main properties and current applications of some polysaccharides as biomaterials

Rinaudo

2007

Polymer International

877

537

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“…XG is biocompatible with several gel-forming and non-gel-forming macromolecules and can even form a stable gel in conjunction with suitable biopolymer systems. Recently, XG has been explored ( − ) as a potential polymer to form hydrogels and as an excipient for tablets in modern medicine (). Some of these hydrogels based on XG have been cross-linked using agents such as epichlorohydrin ( , ).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, XG has been explored ( − ) as a potential polymer to form hydrogels and as an excipient for tablets in modern medicine (). Some of these hydrogels based on XG have been cross-linked using agents such as epichlorohydrin ( , ). Iseki et al have reported the viscoelastic properties of XG hydrogels formed by annealing in the sol state followed by subsequent cooling ().…”

Section: Introductionmentioning

confidence: 99%

Plasma-Enhanced Modification of Xanthan Gum and Its Effect on Rheological Properties

Jampala

Manolache

Gunasekaran

et al. 2005

J. Agric. Food Chem.

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The structure and rheological properties of xanthan gum (XG) modified in a cold plasma environment were investigated. XG was functionalized in a capacitively coupled 13.56-MHz radio frequency dichlorosilane (DS)-plasma conditions and, consecutively, in situ aminated by ethylenediamine. The surface structure of modified XG was evaluated on the basis of survey and high-resolution ESCA, FTIR, and fluorescence labeling techniques. The types of species generated in DS-plasma were reported using residual gas analysis (RGA). The aqueous solutions of modified XG were cross-linked and cured at room temperature to form stable gels. The dynamic rheological characteristics of virgin XG and functionalized and cross-linked XG were compared. It was found that parameters such as plasma treatment time and concentration of solutions can be optimized to form stable gels of XG. Thus, cold plasma technology is a novel, efficient, and nonenzymatic route to modify XG.

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Bioactive polymers 67: isosorbide dinitrate retardation in xanthan-based hydrogels

Dumitriu¹,

Dumitriu²,

Matian³

1991

Colloid Polym Sci

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Bioactive polymers 65—studies of cross-linked xanthan hydrogels as supports in drug retardation

Cited by 5 publications

References 8 publications

Main properties and current applications of some polysaccharides as biomaterials

Main properties and current applications of some polysaccharides as biomaterials

Plasma-Enhanced Modification of Xanthan Gum and Its Effect on Rheological Properties

Bioactive polymers 67: isosorbide dinitrate retardation in xanthan-based hydrogels

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