Bioactive polymers 67: isosorbide dinitrate retardation in xanthan-based hydrogels

Dumitriu, Severian; Dumitriu, Maria; Matian, C.

doi:10.1007/bf00654122

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…41 Nevertheless, the number of network connections can be increased by the addition of a crosslinker, which is a small molecule carrying functional reactive end groups. Table I comprises different crosslinkers [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] used to obtain xanthan networks either in the absence or in the presence of a second polymer. One should note that if the final application is related to biomedical purposes, one must be very careful with unreacted residual crosslinkers.…”

Section: Xanthan Gum Networkmentioning

confidence: 99%

Xanthan gum: A versatile biopolymer for biomedical and technological applications

Petri

2015

J of Applied Polymer Sci

357

189

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Xanthan gum is an extracellular polymer produced mainly by the bacterium Xanthomonas campestris. Traditionally it plays an important role in industrial applications as thickener, emulsion stabilizer and it has been added to water-based drilling fluids due to its pseudoplastic behavior and thermal stability. The structural properties of xanthan in solution can be tuned by the temperature and ionic strength; under high ionic strength or low temperature, xanthan chains are arranged in helical conformation, whereas under low ionic strength or high temperature, xanthan chains are coiled. Xanthan high molecular weight favors the building up of physical and chemical networks, which have been used as carriers for drugs and proteins and as scaffolds for cells. In combination with other polymers xanthan has been applied as excipient in tablets or as supporting hydrogels for drug release applications, particularly due to its acid resistance. The large versatility of xanthan gum opens the possibility for the creation of new architectures and additional applications involving this fascinating polymer. AIMSThe purpose of this review is to report on the applications of xanthan gum in biomedical and technological products over the last ten years, but revisiting the background and the highlights of traditional applications as thickener. The in vivo biodegradability and biocompatibility of xanthan gum are fundamental characteristics that allow its use in biomedical applications. The ability to form networks and acid resistance make xanthan gum, as pure excipient or in combination with other polymers, very attractive as drug carriers. The recent combinations with inorganic particles open a range of new applications.

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Section: Xanthan Gum Networkmentioning

confidence: 99%

Xanthan gum: A versatile biopolymer for biomedical and technological applications

Petri

2015

J of Applied Polymer Sci

357

189

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“…Classical methods consist in the networking reaction of hydroxyl groups of the polysaccharides with epichlorohydrin [22] or acetylation with glyoxal [23]. On the contrary, biopolymers generally have a low impact on the non-specific immune response and most of them are readily hydrolysable.…”

Section: Hydrogel Responsiveness To External Stimulimentioning

confidence: 99%

Soft Condensed Matter in Pharmaceutical Design

Paradossi¹,

Cavalieri²,

Chiessi³

2006

CPD

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In recent years pharmaceutical design has been facing the needs expressed by new therapeutic methodologies such as gene therapy, targeted delivery and closely related diagnostic fields as contrast enhancing agents for ultrasonic investigations. In this context pharmaceutical research has diversified the efforts toward a more integrated approach where the efficacy of an active molecule is enhanced and assisted by the surrounding carrier. Usually this drug platform is a hydrogel matrix, a multicomponent system constituted by an aqueous solution and a polymeric moiety imparting different functions to the matrix, as responsiveness to external stimuli, affinity to receptors, controlled drug release. Such devices represent one of the leading topics of the soft condensed matter recent research, a domain where physics, chemistry and bioengineering cross each other with the aim to achieve an integrated description of these materials. In this respect modern drug design will make use more and more of concepts proper of soft condensed polymer and colloidal sciences. In this review we will describe the state-of-art in the field of the matrices used in innovative drug formulations with a particular emphasis on the implications to pharmaceutical design along with the experimental and theoretical investigation tools worked out in the last decade.

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