Bioactive potentials of endophyte (Fusarium redolens) isolated from Olea europaea

The endophyticFusariumstrains: a treasure trove of natural products

“…Clinical studies in psoriasis showed a reduction of peripheral CD4 + and CD8 + T-lymphocytes due to the ability of fumaric acid esters to induce apoptosis. 53 Fumaric acid esters may cause both renal Fanconi syndrome and acute kidney injury. This effect may be ameliorated by antagonism of the organic anion transporter with probenecid.…”

“…52 The crude extract of F. redolens isolated from Olive (Olea europaea L.) stem resulted in the isolation of chrysophanol (109) and fumaric acid (110); chrysophanol is an anthraquinone having several pharmacological activities such as anticancer, hepatoprotective, neuroprotective, anti-inammatory, and antiulcer, in addition to its antimicrobial potency against various microbial strains, including: C. albicans, C. neoformans, T. mentagrophytes, and A. fumigatus, with MIC values of 50, 50, 25, and 50 mg mL −1 . 53 Fumaric acid (110) is one of the more commonly produced secondary metabolites and it is used in the treatment of psoriasis or multiple sclerosis. Clinical studies in psoriasis showed a reduction of peripheral CD4 + and CD8 + Tlymphocytes due to the ability of fumaric acid esters to induce apoptosis.…”