Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.

Zhao, Hongran; Shao, Chang‐Lun; Li, Zhiyong; Han, Lei; Cao, Fei; Wang, Chang‐Yun

doi:10.3390/molecules18033458

Cited by 30 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pregnane 1021 (Carijoa sp., Weizou Is., S. China Sea) exhibited potent antimicrobial properties. 823 In addition to a number of known congeners, three new mildly cytotoxic polyhydroxylated steroids 1022-1024 were isolated from Sarcophyton sp. (Weizhou Is., S. China Sea).…”

Section: Sesquiterpenes Capillosananementioning

confidence: 99%

Marine natural products

et al. 2015

View full text Add to dashboard Cite

This review covers the literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for the period January to December 2013) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1163 for 2013), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

show abstract

Section: Sesquiterpenes Capillosananementioning

confidence: 99%

Marine natural products

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Two 9,11-secosteroidal glycosides, sinularosides A and B, isolated from the South China Sea soft coral Sinularia humilis, exhibited potent antimicrobial activity (Sun et al 2012). In our previous reports, 86 steroidal compounds were obtained from marine invertebrates and their symbiotic fungi, which exhibited cytotoxic, antiviral and antibacterial activities (Cao et al 2014;Sun et al 2015;Zhao et al 2013).…”

Section: Steroidsmentioning

confidence: 97%

Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application

Liu

Zheng

Shao

et al. 2019

Mar Life Sci Technol

Self Cite

View full text Add to dashboard Cite

Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive molecules with diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites from marine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representative cases are summarized focusing on molecular diversity, mining, and application of natural products from these marine organisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical molecules including their structures, chemical synthesis, bioactivities and mechanisms, structure-activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through the OSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactive natural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and their symbiotic fungi and bacteria.

show abstract

“…Similarly, essential oils distilled from leaves of the plant Ageratum fastiqiatum of Minas Gerais, Brazil, which contains about 14.6% of nonadecane were shown to have antibacterial activity against S. aureus, Streptococcus mutans, Streptococcus faecalis, E. coli and Salmonella typhosa (Del-Vechio-Vieira et al, 2009). Recently, Zhao et al (2013) showed that a pregnane isolated from the marine organism Carijoa sp. exibit promising antibacterial activity against Pseudomonas putida with minimum inhibitory concentration value about five-fold more potent than ciprofloxacin.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Skin Secretion of Bleeding Toad <i>Leptophryne cruentata</i> and Javan Tree Frog <i>Rhacophorus margaritifer</i>

Artika¹,

Pinontoan²,

Kusrini³

2015

American Journal of Biochemistry and Biotechnology

View full text Add to dashboard Cite

Bacterial resistance towards antibiotics has increased morbidity, mortality and health-care costs. Therefore, it is important to search for new types of antibacterial agents. This study was aimed to test antibacterial activity of epinephrine-stimulated skin secretions derived from two species of Anura endemic in Indonesia, the bleeding toad Leptophryne cruentata and the javan tree frog Rhacophorus margaritifer. The filter-sterilized skin secretions were subjected to antibacterial assay against Gram-negative bacterium Escherichia coli and Gram-positive bacterium Staphylococcus aureus. Results showed that skin secretions of some toads and frogs have antibacterial activity against Escherichia coli and Staphylococcus aureus. We conclude that the toad and frog skin secretions have the potential to be used as a source of novel antibacterial agents. To the best of our knowledge, this is the first report on antibacterial activity of skin secretions of Leptophryne cruentata and Rhacophorus margaritifer from Indonesia.

show abstract

Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.

Cited by 30 publications

References 23 publications

Marine natural products

Marine natural products

Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application

Antibacterial Activity of Skin Secretion of Bleeding Toad <i>Leptophryne cruentata</i> and Javan Tree Frog <i>Rhacophorus margaritifer</i>

Contact Info

Product

Resources

About