Bioactive Prodigiosin Isolated from Serratia marcescens using Solid State Fermenter and its Bactericidal Activity Compared with Conventional Antibiotics

M, Arivizhivendhan KV Mahesh; G, Regina Mary R Sekaran

doi:10.4172/1948-5948.1000230

Cited by 8 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…coli , and Klebsiella pneumoniae (Picha et al., 2015). Similar studies reported on the antibacterial activity of Prodigiosin from S. marcescens against P. aeruginosa (Arivizhivendhan et al., 2015) and Prodigiosin from S. marcescens 2170 against some bacterial species.…”

Section: Resultssupporting

confidence: 77%

“…The red pigment prodigiosin from S. marcescens PP1 can capable to inhibit the growth of Gram positive bacteria Bacillus sp and S. aureus and gram negative bacteria Pseudomonas aeruginsa, E. coli, and Klebsiella pneumoniae (Picha et al, 2015). Similar studies reported on the antibacterial activity of Prodigiosin from S. marcescens against P. aeruginosa (Arivizhivendhan et al, 2015) and Prodigiosin from S. marcescens 2170 against some bacterial species.…”

Section: Antibacterial Activitysupporting

confidence: 82%

See 1 more Smart Citation

Prodigiosin pigment from Serratia marcescens MBM‐17 from facial acne as antimicrobial agent

Pallath,

Johnson,

Paul

et al. 2023

Environmental Quality Mgmt

View full text Add to dashboard Cite

A pigment is a naturally occurring colored substance that is created by plants, animals, and microbes. Pigments are utilized in a variety of industries, including food coloring, pharmaceuticals, fabric dying, cosmetics, ink plastics, coloring paints, and so on. The Natural pigments /Bio pigments are very expensive because mass production is difficult. There are more pigments in nature, but only a small number are available in large enough amounts to be useful for industry. This study is attempted to isolate a bacterial red pigmented organism from facial acne was identified as Serratia marcescens MBM‐17 according to Bergey's manual of determinative bacteriology and molecular characterization and production of red pigment was optimized at various growth factors, maximum pigment production was at pH 4, 72 h and 37 ± 2°C, that is, 15.56 g/ L. The partial purified pigment was characterized by UV–Vis, and maximum absorbance was at 533.5 nm. SEM analysis shows that the surface morphology and FTIR spectroscopy revealed the presence of prodigiosin. Prodigiosin has antibacterial efficacy against gram positive bacterial strains, Staphylococcus aureus, Bacillus sp, and gram negative bacterial strains. Klebsiella sp, Pseudomonas sp, Salmonella sp, antifungal potency against Aspergillus niger, Aspergillus flavus, Penicillium sp, Rhizopus sp, and Mucor sp, and checked the fabric dying effects of pigments. Prodigiosin used as fabric dye is applied on clothes, which shows good color tone. This study is highlighting the production of a natural pigment/drug, Prodigiosin with antimicrobial activity may be used for the manufacture of dyed dress materials and masks having antimicrobial action for public especially health workers in this pandemic situation.

show abstract

Section: Resultssupporting

confidence: 77%

Section: Antibacterial Activitysupporting

confidence: 82%

Prodigiosin pigment from Serratia marcescens MBM‐17 from facial acne as antimicrobial agent

Pallath,

Johnson,

Paul

et al. 2023

Environmental Quality Mgmt

View full text Add to dashboard Cite

show abstract

“…with tannery fleshing 1,200 48,000 mg L −1 /40 h 30°C – 8.0 [ 157 ] S. marcescens CF-53 Bioreactor (2 L) Peanut oil cake extract 0.95 40 mg L −1 /42 h 30°C – 7.0 [ 158 ] Serratia sp. KH-95 Bioreactor coupled with extraction system (1 L) 20 g L −1 casein, 1 g L −1 MgSO 4 ⋅7H2O, 1 g L −1 NaCl, and 1.7 g L −1 K 2 HPO 4 400 4,800 mg L −1 /12 h 28°C – 7.0 [ 159 ] S. marcescens JX 1 Bioreactor (200 mL) 20 g L −1 glycerol, 2.0 g L −1 glycine, and 16.0 g L −1 Peptone 135.4 6,500 mg L −1 /48 h 28°C – NR [ 160 ] S. marcescens WT Bioreactor (100 mL) 1% M9 mineral suppl 1% Tannery fleshing 11.9 1,143 mg L −1 /96th 30°C – 6.8 [ 161 ] S. marcescens WT Solid state fermentation (1 Kg) Saline medium supplemented with wheat bran + Tannery fleshing 2,963.7 mg kg −1 h − [ 1 ] 88,910 mg kg −1 /30 days 29°C – 6.8 [ 162 ] S. marcescens UCP 1549 Solid-state fermentation (5 g) Saline medium suppl with food wastes: sugarcane bagasse, instant noodle waste, wheat bran, tangerine peels, pineapple peels, and c...…”

Section: Environmental Factors Influencing Prodigiosin Productionmentioning

confidence: 99%

Prodigiosin: a promising biomolecule with many potential biomedical applications

et al. 2022

View full text Add to dashboard Cite

Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodigiosin (PG) is an alkaloid red bio-dye produced by diverse microorganisms and composed of a linear tripyrrole chemical structure. PG emerges as a really interesting tool since it shows a wide spectrum of biological activities, such as antibacterial, antifungal, algicidal, anti-Chagas, anti-amoebic, antimalarial, anticancer, antiparasitic, antiviral, and/or immunosuppressive. However, PG vehiculation into different delivery systems has been proposed since possesses low bioavailability because of its high hydrophobic character (XLogP3-AA = 4.5). In the present review, the general aspects of the PG correlated with synthesis, production process, and biological activities are reported. Besides, some of the most relevant PG delivery systems described in the literature, as well as novel unexplored applications to potentiate its biological activity in biomedical applications, are proposed.

show abstract

“…In addition, some biotechnological roles of prodigiosin were already reported to have immunosuppressive, antiproliferative, antimalarial, bactericidal, UV protection, antioxidant, and antitumor properties (Burger and Bennett, 1985; Venil, 2009; Borić et al, 2012; Arivizhivendhan et al, 2015; Darshan and Manonmani, 2015; Lapenda et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

The Ecological Coherence of Temperature and Salinity Tolerance Interaction and Pigmentation in a Non-marine Vibrio Isolated from Salar de Atacama

et al. 2016

View full text Add to dashboard Cite

The occurrence of microorganisms from the Vibrio genus in saline lakes from northern Chile had been evidenced using Numerical Taxonomy decades before and, more recently, by phylogenetic analyses of environmental samples and isolates. Most of the knowledge about this genus came from marine isolates and showed temperature and salinity to be integral agents in shaping the niche of the Vibrio populations. The stress tolerance phenotypes of Vibrio sp. Teb5a1 isolated from Salar de Atacama was investigated. It was able to grow without NaCl and tolerated up to 100 g/L of the salt. Furthermore, it grew between 17° and 49°C (optimum 30°C) in the absence of NaCl, and the range was expanded into cold temperature (4–49°C) in the presence of the salt. Other additional adaptive strategies were observed in response to the osmotic stress: pigment production, identified as the known antibacterial prodigiosin, swimming and swarming motility and synthesis of a polar flagellum. It is possible to infer that environmental congruence might explain the cellular phenotypes observed in Vibrio sp. considering that coupling between temperature and salinity tolerance, the production of antibacterial agents at higher temperatures, flagellation and motility increase the chance of Vibrio sp. to survive in salty environments with high daily temperature swings and UV radiation.

show abstract

Bioactive Prodigiosin Isolated from Serratia marcescens using Solid State Fermenter and its Bactericidal Activity Compared with Conventional Antibiotics

Cited by 8 publications

References 20 publications

Prodigiosin pigment from Serratia marcescens MBM‐17 from facial acne as antimicrobial agent

Prodigiosin pigment from Serratia marcescens MBM‐17 from facial acne as antimicrobial agent

Prodigiosin: a promising biomolecule with many potential biomedical applications

The Ecological Coherence of Temperature and Salinity Tolerance Interaction and Pigmentation in a Non-marine Vibrio Isolated from Salar de Atacama

Contact Info

Product

Resources

About