Bioactive Ti alloy with hydrophilicity, antibacterial activity and cytocompatibility

Abstract

Titanium-6 aluminium-4 vanadium (Ti64) alloy was modified to a hydrophilic, cytocompatible, antibacterial and bioactive surface via a simple cost effective chemical treatment method. A fine porous network structure of sodium hydrogen titanate (SHT) was formed on the Ti64 alloy surface by using sodium hydroxide treatment. The incorporated Na + ions are replaced by Ag + ions by a subsequent silver nitrate treatment. Contact angle measurement indicated that the silver containing Ti64 alloy surface is hydrophilic at lower silver concentration. The antibacterial study of the thus prepared sample against Staphylococcus aureus confirmed the bacterial resistance of the Ti64 alloy. As evident from the AAS result, the sustained release of Ag into the culture medium results in antibacterial activity. Cytocompatibility studies on MG63 cell lines showed above 80% cell viability and also good cell attachment. This confirmed the nontoxic behavior of the present optimized silver concentration on the Ti64 surface for MG63 cells. In vitro bioactivity of the silver containing Ti64 sample in simulated body fluid showed bone-like apatite formation and the apatite-forming ability is not affected by Ag concentration or by heat treatment. Taken together, this surface modification study adds further information to our knowledge on the development of a bioactive Ti64 alloy with hydrophilicity, antibacterial activity and biocompatibility that may have considerable potential application as orthopedic and dental implants.

Low‐pressure plasma surface modification of polyurethane films with chitosan and collagen biomolecules

“…After the chemical reaction between activated carboxylic acid and chitosan, the broad peak ranging from 3750 to 2500 cm −1 , which confirmed the presence of carboxylic acid groups on the PU film, was removed from the obtained ATR‐FTIR spectrum. In addition, the peak appeared at 3320 cm −1 refers to the NH and OH groups on the chitosan chain . The characteristic peak at 1685 cm −1 confirms the formation of the amide group, resulting from the reaction of PAA with chitosan .…”

Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment

“…Kizuki et al [28] and Prabu et al [44] demonstrated that Ag can be induced into SHT formed on Ti and Ti-6Al-4V alloy as ion form by soaking the metals in 0.01-100 mM Ag(NO) 3 solution after the NaOH solution. However, metallic Ag particles were formed again when the treated metals were subsequently heat-treated at 600 • C [28].…”

Neodymium-decorated graphene oxide as a corrosion barrier layer on Ti6Al4V alloy in acidic medium

“…[86][87][88][89][90] The peaks in both diffractograms were indexed to the alfa Ti phase, and no clear presence of the beta-Ti phase, and none of Ti oxides or other corrosion products was found, although ATR-FTIR results suggest the formation of Ti-O-Ti bond that could arise from surface TiO 2 . [91][92][93][94][95] The relatively higher peak intensities in the spectrum of epoxy reference coating arises from its lower thickness (ca. 10 micrometers) compared to that of the GO + Nd (ca.…”