Bioactivities and serum pharmacochemistry of<i>Qi-Wei-Xiao-Yan-Tang</i>

He, Xiao-Yan; Liu, Qingchun; Peng, Wei; Huang, Yong‐Liang; Wu, Chunjie

doi:10.3109/13880209.2012.761243

Cited by 29 publications

(17 citation statements)

References 26 publications

(21 reference statements)

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“…HWTX is an anti-bacterial agent which is also known to purge heat and flatulence from the bowels. Previous studies showed that the herbal components of HWTX possess significant beneficial effects against inflammatory reactions and gastrointestinal dysfunction [12,17,18]. In the present investigation, the results obtained indicate that HWTX in combination with standard AP treatment significantly improved AP syndromes when compared with control patients.…”

Section: Discussionsupporting

confidence: 71%

Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction

Jin¹,

Li²,

Song³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 71%

Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction

Jin¹,

Li²,

Song³

et al. 2017

Trop. J. Pharm Res

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“…The xylene-induced ear edema in mice is a preliminary and simple model for screening potential antiinflammatory drugs [10]. The results of xylene-induced ear edema showed that GL had a significant anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

“…), and vehicle+GL (160 mg/kg, i.p.). Xylene-induced ear edema in mice was initiated according to a method previously described by He et al [10]. Briefly, each group was pre-treated with the drugs.…”

Section: Xylene-induced Ear Edema Testmentioning

confidence: 99%

Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice

Wang

Niu

et al. 2015

Inflammation

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The present study aimed to investigate the potential anti-inflammatory and anti-nociceptive activities of glycyrrhizin (GL) in mice and to explore the possible related mechanisms. Xylene-induced ear edema, carrageenan-induced paw edema and acetic acid-induced vascular permeability test were used to investigate the anti-inflammatory activities of GL in mice. Anti-nociceptive effects of GL were assessed by using acetic acid-induced writhing, hot plate test and formalin test, as well as evaluation of spontaneous locomotor activity and motor performance. The mRNA expression of pro-inflammatory cytokines (such as TNF-α, IL-6 and iNOS) and the protein expression of cyclooxygenase-2 (COX-2) were explored by using real-time fluorogenic PCR and Western blot, respectively. The results showed that GL significantly reduced xylene-induced ear edema, carrageenan-induced paw edema, and acetic acid-induced vascular permeation. Additionally, GL significantly inhibited the nociceptions induced by acetic acid and formalin. However, the nociceptions could not be decreased by GL in the hot plate test, and GL did not affect spontaneous locomotor activity and motor performance. The expression levels of TNF-α, IL-6, iNOS and COX-2 were significantly downregulated by GL. In conclusion, GL exerts significant anti-inflammatory and analgesic activities by attenuating the expression levels of TNF-α, IL-6, iNOS and COX-2.

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“…Dimethylbenzene-induced ear edema in mice, produced as described by He et al [20], was used to evaluate the anti-inflammatory activity of MEAP. Briefly, MEAP was administered orally 1 h before dimethylbenzene topical application to the right ear.…”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory and Anti-Nociceptive Activities of Methanol Extract from Aerial Part of Phlomis younghusbandii Mukerjee

et al. 2014

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This study was designed to investigate the anti-inflammatory and anti-nociceptive activity of the methanol extract from the aerial part of Phlomis younghusbandii (MEAP) and to explore the possible related mechanisms. Anti-inflammatory effects of MEAP were evaluated by using the ear edema test induced by dimethylbenzene and vascular permeability test induced by acetic acid. Anti-nociceptive activities of MEAP were evaluated by the chemical nociception in models of acetic acid-induced writhing and formalin-induced hind paw licking, and by the thermal nociception in hot plate tests. Mechanisms of MEAP activities also were explored by evaluating expression levels of TNF-α, IL-6 and iNOS induced by LPS using real-time fluorogenic PCR and expression of COX-2 using Western blotting and an open-field test. The results indicated that the MEAP administered orally could significantly decrease ear edema induced by dimethylbenzene and increase vascular permeability induced by acetic acid. Additionally, the nociceptions induced by acetic acid and formalin were significantly inhibited. The anti-nociceptive effect could not be decreased by naloxone in the formalin test, and MEAP did not affect the normal autonomic activities of mice. Expression levels of pro-inflammatory cytokines (TNF-α, IL-6, iNOS) induced by LPS were decreased obviously by treatment with MEAP. Furthermore, COX-2 expression in the spinal dorsal horns of the pain model mice induced by formalin was significantly down-regulated by MEAP. In conclusion, MEAP has significant anti-inflammatory and antinociceptive activities, and the mechanisms may be related to the down-regulated expression of TNF-α, IL-6, iNOS and COX-2.

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Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Cited by 29 publications

References 26 publications

Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction

Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction

Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice

Anti-Inflammatory and Anti-Nociceptive Activities of Methanol Extract from Aerial Part of Phlomis younghusbandii Mukerjee

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