Bioactivity and biocompatibility of a chitosan-tobermorite composite membrane for guided tissue regeneration

Hurt, Andrew P.; Getti, Giulia; Coleman, Nichola J.

doi:10.1016/j.ijbiomac.2013.11.020

Cited by 43 publications

(32 citation statements)

References 23 publications

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“…bending modes which give rise to the bands at 1430-1420 cm −1 [4,9]. Carbonyl C=O stretching modes appear at ∼ 1650 cm −1 , various C-O-C stretching frequencies occur in the range 1160-1060 cm −1 and the band at ∼ 1295 cm −1 is attributed to C-O-H stretching vibrations in all polymer samples.…”

Section: In Vitro Bioactivity Of Composite Spongesmentioning

confidence: 87%

“…The in vitro bioactivity of the sponges was evaluated by immersion in SBF for 3 and 7 days, as described elsewhere [4]. Their swelling capacity at 72 h in SBF was evaluated using the following formula (Eq.…”

Section: Methodsmentioning

confidence: 99%

“…In the FTIR spectrum of chitosan (Fig. 3c), the broad signal at ∼ 3460 cm −1 is attributed to N-H and O-H stretching modes, which overlap in this region; and the bands at 1650 and 1570 cm −1 arise from amide I C=O stretching and amide II N-H bending vibrations, respectively [4]. A peak shift to lower wavenumber is seen in the amide I band of chitosan in the A5 sponge, indicating an interaction between the two polymers, which confirms polyelectrolyte complex formation.…”

Section: In Vitro Bioactivity Of Composite Spongesmentioning

confidence: 98%

“…Chitosan is the partially N-deacetylated derivative of chitin, obtained on an industrial scale from crustacean shells and some fungi, which is soluble under mildly acidic * corresponding author; e-mail: n.coleman@gre.ac.uk conditions. It is a linear co-polymer of D-glucosamine and N-acetylglucosamine, whose structure resembles that of bone extracellular matrix [4]. Alginate and chitosan are reported to be both biodegradable and biocompatible with bone tissue, with some evidence that chitosan is also bioactive with respect to bone tissue regeneration [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Composite Sponges for in Situ Alveolar Bone Regeneration Following Tooth Extraction

et al. 2017

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This research concerns the development of solvent-cast lyophilised composite sponges in the bioactive glassalginate-chitosan system for alveolar bone tissue maintenance following tooth extraction. Hydroxyapatite formed on the surfaces of pure alginate, 50:50 alginate:chitosan blend and pure chitosan sponges blended with 10 wt.% bioactive glass within 7 days of exposure to simulated body fluid, indicating that they possess the potential to stimulate bone tissue formation. In the absence of bioactive glass, pure chitosan sponges also demonstrated in vitro bioactivity, to a lesser extent; unlike pure alginate and 50:50 alginate:chitosan blend, which did not. All samples formed macroporous sponges whose biocompatibility with human osteosarcoma cells increased as a function of chitosan-content. Polyelectrolyte complex formation between alginate and chitosan, and the incorporation of bioactive glass were found to increase the swelling capacity of the sponges in SBF. The findings of this study demonstrate that, bioactive glass-chitosan sponges are the favoured candidates for alveolar bone tissue augmentation as their rate of hydroxyapatite formation and biocompatibility are superior to those of the other samples.

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Section: In Vitro Bioactivity Of Composite Spongesmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: In Vitro Bioactivity Of Composite Spongesmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Composite Sponges for in Situ Alveolar Bone Regeneration Following Tooth Extraction

et al. 2017

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“…These results showed that the oral administration of low molecular weight chitosan is effective in alleviating the allergic inflammation in vivo and thus can be a good material for the development of a potent therapeutic agent against mast cell-mediated allergic inflammatory responses and airway inflammation in allergic inflammatory diseases. Polysaccharides DOI 10.1007/978-3-319-03751-6_17-1 # Springer International Publishing Switzerland 2014 Chitosan-tobermorite composite membrane was prepared by solvent casting a mixture of chitosan and tobermorite from acetic acid solution (Hurt et al 2014). The bioactivity and biocompatibility of the composite were evaluated with respect to its potential for use as a biodegradable guided tissue regeneration membrane.…”

Section: Anti-inflammatory and Tissue Regeneration Activitymentioning

confidence: 99%

Bioactivity of Chitosan Derivative

Prabaharan

2014

Polysaccharides

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Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is composed of glucosamine and N-acetylglucosamine monomers. Chitosan and its derivatives have a great potential for a wide range of applications in biomedical, pharmaceutical, food, cosmetics, and environmental fields due to its biodegradability, biocompatibility, nontoxicity, and versatile chemical and physical properties. For a breakthrough in utilization, especially in the biomedical field, chemical modification of chitosan will be a key point that can introduce desired properties and enlarge the field of the potential applications of chitosan. Different approaches have been reported to prepare chitosan derivatives and chitosan oligomers with low, medium, and high molecular weights. In this chapter, the properties such as biodegradation, antimicrobial activity, anti-inflammatory and tissue regeneration activity, wound-healing properties, antioxidant activity, and antitumor activity of chitosan and its derivatives are discussed in detail.

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Asymmetric resorbable‐based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

Bee

Hamid

2022

J Biomed Mater Res

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Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are two common dental regenerative treatments targeted at reconstructing damaged periodontal tissue and bone caused by periodontitis. During GTR/GBR treatment, a barrier membrane is placed in the interface between the soft tissue and the periodontal defect to inhibit soft tissue ingrowth and creating a space for the infiltration of slowgrowing bone cells into the defect site. Recently, asymmetric resorbable-based barrier membrane has received a considerable attention as a new generation of GTR/GBR membrane. Despite numerous literatures about asymmetric-based membrane that had been published, there is lacks comprehensive review on asymmetric barrier membrane that particularly highlight the importance of membrane structure for periodontal regeneration. In this review, we systematically cover the latest development and advancement of various kinds of asymmetric barrier membranes used in periodontal GTR/GBR application. Herein, the ideal requirements for constructing a barrier membrane as well as the rationale behind the asymmetric design, are firstly presented. Various innovative methods used in fabricating asymmetric barrier membrane are being further discussed. Subsequently, the application and evaluation of various types of asymmetric barrier membrane used for GTR/GBR are compiled and extensively reviewed based on the recent literatures reported. Based on the existing gap in this field, the future research directions of asymmetric resorbable-based barrier membrane such as its combination potential with bone grafts, are also presented.

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Bioactivity and biocompatibility of a chitosan-tobermorite composite membrane for guided tissue regeneration

Cited by 43 publications

References 23 publications

Composite Sponges for in Situ Alveolar Bone Regeneration Following Tooth Extraction

Composite Sponges for in Situ Alveolar Bone Regeneration Following Tooth Extraction

Bioactivity of Chitosan Derivative

Asymmetric resorbable‐based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

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