Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years

Huang, Le-Jun; Lan, Jin-Xia; Wang, Jin-Hua; Huang, Hao; Lu, Kuo; Zhou, Zhi-Nuo; Xin, Su-Ya; Zhang, Zi-Yun; Wang, Jing-Yang; Dai, Ping; Chen, Xiao-Mei; Hou, Wen

doi:10.1016/j.biopha.2024.116406

Cited by 7 publications

(5 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sanguinarine has been described to be toxic to host cell, thought to be due to its action on Na+/K+ ATPase, although other mechanisms have also been described 48 . Although we did not measure appreciable cell toxicity in our assays, other studies have indicated sanguinarine induces apoptosis or blocks cell growth 49 . Additionally, the LD 50 in mouse is 18 mg/kg by i.p.…”

Section: Resultsmentioning

confidence: 73%

“…Additionally, the LD 50 in mouse is 18 mg/kg by i.p. injection 49 , likely limiting its use in efficacy testing for toxoplasmosis.…”

Section: Resultsmentioning

confidence: 99%

“…Sanguinarine sulfate is a natural product produced by the opium poppy and several other plants and it consists of a benzoquinoline alkaloid 48 . Sanguinarine has anti-inflammatory, anti-tumor and antimicrobial activities and it is thought to act on numerous signaling pathways in human cells 49 . Sanguinarine has been described to be toxic to host cell, thought to be due to its action on Na+/K+ ATPase, although other mechanisms have also been described 48 .…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

Uddin,

Xia,

et al. 2024

Preprint

View full text Add to dashboard Cite

Toxoplasma gondiicauses widespread chronic infections that are not cured by current treatments due to inability to affect semi-dormant bradyzoite stages within tissue cysts. To identify compounds to eliminate chronic infection, we developed a HTS using a recently characterized strain ofT. gondiithat undergoes efficient conversion to bradyzoites in intro. Stage-specific expression of luciferase was used to selectively monitor growth inhibition of bradyzoites by the Library of Pharmacological Active Compounds, consisting of 1280 drug-like compounds. We identified 44 compounds with >50% inhibitory effects against bradyzoites, including several new highly potent compounds several of which have precedent for antimicrobial activity. Subsequent characterization of the compound Sanguinarine sulfate revealed potent and rapid killing against in vitro produced bradyzoites and bradyzoites harvested from chronically infected mice. These findings provide a platform for expanded screening and identify promising compounds for further preclinical development againstT. gondiibradyzoites responsible for chronic infection.

show abstract

Section: Resultsmentioning

confidence: 73%

“…Additionally, the LD 50 in mouse is 18 mg/kg by i.p. injection 49 , likely limiting its use in efficacy testing for toxoplasmosis.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

Uddin,

Xia,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Sanguinarine, a benzophenanthridine alkaloid derived from Sanguinaria canadensis ( Croaker et al, 2017 ), has demonstrated antibacterial, anti-inflammatory, and antifungal properties ( Huang et al, 2024 ). In studies both in vitro and in vivo , Pallichankandy S et al found that sanguinarine suppresses the growth of human colorectal cancer cells by inducing oxeiptosis ( Pallichankandy et al, 2023 ).…”

Section: Regulator Of Oxeiptosismentioning

confidence: 99%

Mini-review: research and progress of oxeiptosis in diseases

Chen,

Wang,

Lei

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Oxeiptosis is a novel cell death pathway that was introduced in 2018. As a form of regulated cell death, it operates independently of caspases and is induced by ROS. Distinguished from other cell death pathways such as apoptosis, necroptosis, pyroptosis, and ferroptosis, oxeiptosis features unique damage causes pivotal genes, and signaling pathways (KEAP1/PGAM5/AIFM1). Emerging studies indicate that oxeiptosis plays a significant role in the progression of various diseases and its regulation could serve as a promising therapeutic target. However, the precise molecular mechanisms underlying oxeiptosis remain to be fully elucidated. In this mini-review, we systematically summarize the latest developments in oxeiptosis-related diseases while detailing the molecular mechanisms and regulatory networks of oxeiptosis. These insights offer a foundation for a deeper understanding of oxeiptosis.

show abstract

“…The bioactivity of benzophenanthridine alkaloids has acquired significant interest due to their potential as therapeutic agents [8]. Sanguinarine (2), for instance, exhibits potent antimicrobial activity against a range of pathogens, including bacteria, fungi, protozoa, and other relevant biological properties [9]. Chelerythrine (3) has shown capacity as an anticancer agent by inducing apoptosis in cancer cells [10] and even antifungal action [11].…”

Section: Introductionmentioning

confidence: 99%

N-Methoxycarbonyl-9,12-Dimethoxy-Norchelerythrine: A Novel Antifungal Type-III Benzo[c]phenanthridine from Zanthoxylum simulans Hance Seedlings

Cárdenas-Laverde,

Quiroga,

Coy-Barrera

2024

Molbank

View full text Add to dashboard Cite

Zanthoxylum simulans Hance, commonly known as Sichuan pepper, is a well-known medicinal plant recognized for its potential as a source of bioactive specialized metabolites. As part of our interest in natural antifungal compounds, the present study describes the discovery of an unreported N-alcoxycarbonylbenzo[c]phenanthridinium salt, N-methoxycarbonyl-9,12-dimethoxy-norchelerythrine 1 (a type-III benzo[c]phenanthridine), isolated from Z. simulans seedlings, which were propagated under controlled greenhouse conditions. Six-month seedlings were harvested and subjected to cold acid–base extraction. Chromatographic techniques achieved the isolation of 1 from raw alkaloid extract. The structural elucidation of 1 was accomplished through comprehensive spectroscopic analysis, including nuclear magnetic resonance and high-resolution mass spectrometry. Fusarium oxysporum, a fungal pathogen responsible for substantial agricultural losses, was exposed to different concentrations of the novel compound, exhibiting potent antifungal efficacy (IC50 < 3 µM) and fungicide effects. These findings highlight the potential of benzophenanthridines as antifungal leads and underscore the importance of exploring natural products for agricultural applications.

show abstract

Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years

Cited by 7 publications

References 120 publications

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

Mini-review: research and progress of oxeiptosis in diseases

N-Methoxycarbonyl-9,12-Dimethoxy-Norchelerythrine: A Novel Antifungal Type-III Benzo[c]phenanthridine from Zanthoxylum simulans Hance Seedlings

Contact Info

Product

Resources

About