Bioactivity Enhancement of Titanium Induced by Nd: Yag Laser Pulses

Radmanesh, Mitra; Kiani, Amirkianoosh

doi:10.5301/jabfm.5000258

Cited by 10 publications

(16 citation statements)

References 24 publications

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“…Structural difference of laser texturing samples leads to diverse surface properties(Radmanesh & Kiani, ; Rebollar et al, ; Vilhena et al, ), which will subsequently affect their biocompatibility. In the experiments, the elemental distribution of the polished and laser‐treated TC4 samples was examined by EDS.…”

Section: Resultsmentioning

confidence: 99%

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Picosecond laser texturing on titanium alloy for biomedical implants in cell proliferation and vascularization

et al. 2019

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Introducing specific textures to titanium alloy implant surface is helpful to modify the surface properties of materials. In this article, biomedical TC4 (Ti‐6Al‐4V) alloy was textured by a 10‐ps infrared laser. Laser parameters that directly affected the detailed dimension of textures and its characteristics were optimized within laser power, defocusing amount, and scanning parameters via response surface methodology. These textures consisted of groove array about 30–90 μm in depth and 100 μm in width were prepared and their surface property (including surface morphology, element composition, wetting behavior, and biocompatibility) was analyzed. Surface characteristic analysis indicated that picosecond laser texturing improved surface properties and biocompatibility mainly by altering the microstructure and morphology of materials. In addition, laser textured groove array promoted contact area and hydrophobicity of material surface. Cell culture experiments and animal studies showed that titanium alloy implants with 30‐ and 60‐μm‐deep groove arrays on the surface‐enhanced cell proliferation and adhesion. Meanwhile, compared to the polished samples, these groove arrays promoted the growth of new blood vessels and enhanced the combination of blood vessel and implants in vivo. That is, the deeper groove array was, and the better vascularizing effect the blood vessel exhibited.

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Section: Resultsmentioning

confidence: 99%

“…Previous studies showed that the wettability was one of the main factors affecting cell proliferation and adhesion(Radmanesh & Kiani, ; Rebollar et al, ; Vilhena et al, ). Different surface‐texturing technologies have different effects on the surface wettability of materials.…”

Section: Discussionmentioning

confidence: 98%

Picosecond laser texturing on titanium alloy for biomedical implants in cell proliferation and vascularization

et al. 2019

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“…Surface topography properties consist of three main characteristics: lay, roughness, and waviness. [12][13][14] The topographical properties of a material, particularly roughness, are very influential on cell attachment and cell behavior. 2,3 Laser treatment influences all properties of topography, particularly the roughness, surface profile, and oxidation of the treated material, which are closely examined in Sec.…”

Section: Resultsmentioning

confidence: 99%

“…Oxidation directly affects the surface energy of the material, and hence with a higher oxidation, better cell adhesion is expected. 5,12,16 During laser irradiation, a plume with radial surface tension is created surrounding the heat-affected zone due to the temperature gradient caused by energy transfer. This vaporized plume (plasma) consists of nanoparticles, ions, and clusters that are created through the ablation of the material during laser irradiation.…”

Section: B Effects Of Laser Treatment-oxidation Levelmentioning

confidence: 99%

Mouse embryonic fibroblasts accumulate differentially on titanium surfaces treated with nanosecond laser pulses

et al. 2016

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Biomaterial engineering, specifically in bone implant and osseointegration, is currently facing a critical challenge regarding the response of cells to foreign objects and general biocompatibility of the materials used in the production of these implants. Using the developing technology of the laser surface treatment, this study investigates the effects of the laser repetition rate (frequency) on cell distribution across the surface of the titanium substrates. The main objective of this research is building a fundamental understanding of how cells interact with treated titanium and how different treatments affect cell accumulation. Cells respond differently to surfaces treated with different frequency lasers. The results of this research identify the influence of frequency on surface topography properties and oxidation of titanium, and their subsequent effects on the pattern of cell accumulation on its surface. Despite increased oxidation in laser-treated regions, the authors observe that fibroblast cells prefer untreated titanium to laser-treated regions, except the regions treated with 25 kHz pulses, which become preferentially colonized after 72 h.

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“…There are also many potential applications in biomedical engineering. It’s been proven that laser processing a metallic surface can significantly improve the biocompatibility in the ablated area and living cells can adhere better to the surface [ 9 – 13 ] whereas, the heat affected zone becomes less biocompatible and cells will avoid that area [ 14 ]. Therefore, the growing pattern of the cells can be controlled by laser processing of the surface which has many potential applications in biomedical engineering.…”

Section: Introductionmentioning

confidence: 99%

Laser processing of thin-film multilayer structures: comparison between a 3D thermal model and experimental results

Naghshine¹,

Kiani²

2017

Beilstein J. Nanotechnol.

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In this research, a numerical model is introduced for simulation of laser processing of thin film multilayer structures, to predict the temperature and ablated area for a set of laser parameters including average power and repetition rate. Different thin-films on Si substrate were processed by nanosecond Nd:YAG laser pulses and the experimental and numerical results were compared to each other. The results show that applying a thin film on the surface can completely change the temperature field and vary the shape of the heat affected zone. The findings of this paper can have many potential applications including patterning the cell growth for biomedical applications and controlling the grain size in fabrication of polycrystalline silicon (poly-Si) thin-film transistors (TFTs).

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Bioactivity Enhancement of Titanium Induced by Nd: Yag Laser Pulses

Cited by 10 publications

References 24 publications

Picosecond laser texturing on titanium alloy for biomedical implants in cell proliferation and vascularization

Picosecond laser texturing on titanium alloy for biomedical implants in cell proliferation and vascularization

Mouse embryonic fibroblasts accumulate differentially on titanium surfaces treated with nanosecond laser pulses

Laser processing of thin-film multilayer structures: comparison between a 3D thermal model and experimental results

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