Bioactivity of food melanoidins is mediated by gut microbiota

Pérez-Burillo, Sergio; Rajakaruna, Sumudu; Pastoriza, Silvia; Paliy, Oleg; Rufián-Henares, José Ángel

doi:10.1016/j.foodchem.2020.126309

Cited by 100 publications

(98 citation statements)

References 43 publications

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“…In mice, feeding coffee led to higher levels of acetate, propionate and butyrate [86][87][88]. Candidate prebiotic constituents of coffee are soluble arabinogalactans and galactomannans, melanoidins and polyphenols [89][90][91]. However, in male Tsumura Suzuki obese diabetes mice, a mouse model of metabolic syndrome, daily coffee intake prevented nonalcoholic steatohepatitis but did not repair the altered levels of Gram-positive and Gram-negative bacteria and the increased abundance of Firmicutes, nor was there improvement of the disrupted short chain fatty acid profile [92].…”

Section: Other Possible Pathways Of Coffee-mediated Health Effectsmentioning

confidence: 99%

Health Effects of Coffee: Mechanism Unraveled?

2020

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The association of habitual coffee consumption with a lower risk of diseases, like type 2 diabetes mellitus, chronic liver disease, certain cancer types, or with reduced all-cause mortality, has been confirmed in prospective cohort studies in many regions of the world. The molecular mechanism is still unresolved. The radical-scavenging and anti-inflammatory activity of coffee constituents is too weak to account for such effects. We argue here that coffee as a plant food has similar beneficial properties to many vegetables and fruits. Recent studies have identified a health promoting mechanism common to coffee, vegetables and fruits, i.e., the activation of an adaptive cellular response characterized by the upregulation of proteins involved in cell protection, notably antioxidant, detoxifying and repair enzymes. Key to this response is the activation of the Nrf2 (Nuclear factor erythroid 2-related factor-2) system by phenolic phytochemicals, which induces the expression of cell defense genes. Coffee plays a dominant role in that regard because it is the major dietary source of phenolic acids and polyphenols in the developed world. A possible supportive action may be the modulation of the gut microbiota by non-digested prebiotic constituents of coffee, but the available data are still scarce. We conclude that coffee employs similar pathways of promoting health as assumed for other vegetables and fruits. Coffee beans may be viewed as healthy vegetable food and a main supplier of dietary phenolic phytochemicals.

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Section: Other Possible Pathways Of Coffee-mediated Health Effectsmentioning

confidence: 99%

Health Effects of Coffee: Mechanism Unraveled?

2020

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“…Therefore, melanoidins are brown coloured, heterogeneous, polymeric high molecular weight compounds present in a wide variety of food, such as bakery products and coffee (Alves, Xavier, Limoeiro & Perrone, 2020, Fogliano & Morales, 2011, Gonzalez-Mateo, Gonzalez-Sanjose & Muñiz, 2009, cocoa beans (Oracz & Zyzelewicz, 2019), sweet wine (Goulas, Nicolaou, Botsaris & Barbouti, 2018, Ortega-Heras & González-Sanjosé, 2009, etc, which make them a part of the general population daily diet. In this sense, it has been estimated that around 10-12 grams of melanoidins from all the possible alimentary sources are ingested everyday by general population (Alves, Xavier, Limoeiro & Perrone, 2020, Fogliano & Morales, 2011, Pastoriza & Rufián-Henares, 2014, Perez-Burillo, Rajakaruna, Pastoriza, Paliy & Angel Rufian-Henares, 2020. In Spain, melanoidins are mainly ingested from bakery products, and the intake of melanoidins isolated from bread ranges between 1.8 to 15 g per day and from biscuits is around 3.2-8.5 g/day (Fogliano and Morales 2011).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity study of bakery product melanoidins on intestinal and endothelial cell lines

et al. 2021

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…The increased Bi dobacterium in rumen of lamb were associated with the improved contents of meat nutrients comprising alpha-linolenic acid, conjugated linoleic acid and eicosapentaenoic acid [44]. Lactobacilli and Bi dobacterium are considered by the European Food Safety Authority, indicating they can be considered possible prebiotics for improvement of gut health [45]. Bi dobacteria was abundant in the digestive tract of humans, which has assumed health-promoting activities [46].…”

Section: Discussionmentioning

confidence: 99%

“…Vlková et al [47] also found that the supplementation of Bi dobacterium strains promoted rumen health for calves in the milkfeeding period. On the other hand, Bi dobacteria can utilize a variety of iso avones, mono-and oligosaccharide, and polysaccharides [45]. Mulberry leaf contains abundant polysaccharides and other plant secondary metabolites [41,48], thus the increased abundance of rumen Bi dobacteria in the MS group might due to the feeding of mulberry leaf silage.…”

Section: Discussionmentioning

confidence: 99%

Mining Novel Specific Rumen Bacteria to Enhance the Bioactive Function of Mulberry Leaf in Promoting Host Antioxidant Activity and Immunomodulatory

Wang¹,

Luo²

2020

Preprint

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Background: Rumen is a natural fermentation system and the microorganisms inside can effectively utilize plant bioresource and interact with host metabolism. Here, analysis of rumen microbiome, together with animal performance and serum metabolism in a lamb model were performed to identify the potential use of mulberry leaf silage (MS) to replace alfalfa silage (AS) as a new functional feed resource and to mining the novel specific mulberry leaf associated rumen bacteria interact with host metabolism. Results: The lambs fed with MS diet showed improved antioxidant capacity and immune function compared to those fed AS diet. The MS diet significantly altered rumen microbiota α- and β-diversity and taxonomic composition. Microbial analysis revealed that Bifidobacterium, Lactobacillus and Schwartzia were enhanced, and Ruminococcaceae UCG-010 and Lachnospiraceae_XPB1014_group were down-regulated in the rumen of MS group. A strong association was also found between these rumen microbial taxa and host antioxidant capacity and immunomodulatory. Conclusion: These findings indicated that mulberry leaf silage can be a high-quality feed source or bioactive pharmaceutical that is responsible for ruminants health benefits by modifying the rumen microbial community with potentially enhanced probiotics and inhibited biohydrogenation and methane emission.

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Bioactivity of food melanoidins is mediated by gut microbiota

Cited by 100 publications

References 43 publications

Health Effects of Coffee: Mechanism Unraveled?

Health Effects of Coffee: Mechanism Unraveled?

Cytotoxicity study of bakery product melanoidins on intestinal and endothelial cell lines

Mining Novel Specific Rumen Bacteria to Enhance the Bioactive Function of Mulberry Leaf in Promoting Host Antioxidant Activity and Immunomodulatory

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