2013
DOI: 10.5897/ajpp2013.3447
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Bioactivity of gentamicin contained in novel transdermal drug delivery systems (TDDS) formulated with biodegradable polyesters

Abstract: Topical administration of gentamicin, a hydrophilic aminoglycoside antibiotic, is limited by membrane impermeability and toxicity concerns. The purpose of this study was to develop and evaluate the antimicrobial activities of an alternative non-invasive, convenient and cost-effective transdermal drug delivery system (TDDS) containing gentamicin in biodegradable polyester-based matrices. The patches were formulated by solvent evaporation technique using PURASORB ® polymers and evaluated for thermal properties, … Show more

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Cited by 5 publications
(7 citation statements)
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“…Gentamicin can be used as a comparison to MP due to their similarity in the mode of action, that is, both of them inhibit protein synthesis inside the bacteria. 26 , 27 This method helps to evaluate the antimicrobial activity of drugs such as MP and gentamicin against S. aureus , which leads to determination of the antimicrobial susceptibility of patches.…”
Section: Discussionmentioning
confidence: 99%
“…Gentamicin can be used as a comparison to MP due to their similarity in the mode of action, that is, both of them inhibit protein synthesis inside the bacteria. 26 , 27 This method helps to evaluate the antimicrobial activity of drugs such as MP and gentamicin against S. aureus , which leads to determination of the antimicrobial susceptibility of patches.…”
Section: Discussionmentioning
confidence: 99%
“…Technologies for formulation change provide the benefit of improving pharmaceutical product efficacy and safety as well as patient convenience; these technologies provide a relatively simple approach to creating new pharmaceuticals compared with new drug discovery because the active compounds used in the formulation have already been approved [29][30][31]. Nnamani et al [32] developed and evaluated the antimicrobial activities of an alternative non-invasive, convenient and cost-effective transdermal drug delivery system (TDDS) containing gentamicin in biodegradable polyester-based matrices. Other drugs which have been formulated for dermal and transdermal delivery are nitroglycerin, nicotine, scopolamine, clonidine, fentanyl, 17-β-estradiol, testosterone, Boswellic acid (Boswellia serrata) and curcumin (Curcuma longa).…”
Section: Ideal Drugs For Dermal and Transdermal Deliverymentioning
confidence: 99%
“…Our earlier work demonstrated the possibility of administering GEN as a fast-release topical agent (microgels) using an optimized nanostructured lipid carrier (NLC) regimen with excellent microbial growth inhibition [12]. Therefore, innovative wound dressing relies on good hydration as the single most important external factor responsible for optimal wound healing [17][18][19]. Healing under wet and moist environments has been clearly demonstrated to be significantly faster than under dry conditions [18].…”
Section: Introductionmentioning
confidence: 99%
“…The optimum wound healing environment is intermediate gelatinous between moist and dry, as seen in highly vapor-permeable dressings [1,20]. Some mechanisms attributed to this improved wound healing include increased partial pressure of oxygen, preferred migration of epidermal cells over moist wound surfaces than under dry scabs, preservation of growth factors, and presence of proteinases in fluid exudates [19]. Increased moisture impedes capillary activity and reduces hyperemia and collagen deposition.…”
Section: Introductionmentioning
confidence: 99%
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