Bioactivity of glycolipopeptide cell-bound biosurfactants against skin pathogens

Vecino, Xanel; Rodríguez‐López, Lorena; Ferreira, Débora; Cruz, J.M.; Rodrigues, L. R.

doi:10.1016/j.ijbiomac.2017.11.088

Cited by 64 publications

(43 citation statements)

References 33 publications

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“…Our results are in accordance with those of Vecino et al ( 2018 ) who reported that the pre-treatment of a polystyrene surface with biosurfactants produced by Lactobacillus pentosus and Lactobacillus paracasei inhibited bacterial and C. albicans adhesion by 30–81%. In another study, Gudiña et al ( 2010b ) reported that the highest antiadhesive activity of the biosurfactant produced by L. paracasei was observed against Staphylococcus aureus (72.0%) and S. epidermidis (62.1%) at a concentration of 25 mg mL −1 .…”

Section: Resultssupporting

confidence: 93%

“…Also, we have shown that biosurfactants have strong antiadhesive activities against bacterial and yeast strains on a polystyrene surface (Janek et al, 2013b ). Vecino et al ( 2018 ) have reported significant antiadhesive properties of glycolipopeptide cell-bound biosurfactants against all of the tested microorganisms, except E. coli and C. albicans (<30% antiadhesive activity). Although there are a few intensive studies on the antimicrobial and antiadhesive activities of biosurfactants, much work is still needed to understand the mechanism of action of the surface-active compounds.…”

Section: Introductionmentioning

confidence: 98%

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Trehalose Lipid Biosurfactant Reduces Adhesion of Microbial Pathogens to Polystyrene and Silicone Surfaces: An Experimental and Computational Approach

et al. 2018

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Rhodococcus fascians BD8, isolated from Arctic soil, was found to produce biosurfactant when grown on n-hexadecane as the sole carbon source. The glycolipid product was identified as the trehalose lipid with a molecular mass of 848 g mol−1. The purified biosurfactant reduced the surface tension of water from 72 to 34 mN m−1. The critical micelle concentration of trehalose lipid was 0.140 mg mL−1. To examine its potential for biomedical applications, the antimicrobial and antiadhesive activity of the biosurfactant was evaluated against several pathogenic microorganisms. Trehalose lipid showed antimicrobial activity against resistant pathogens. The largest antimicrobial activities of trehalose lipid were observed against Vibrio harveyi and Proteus vulgaris. The highest concentration tested (0.5 mg mL−1) caused a partial (11–34%) inhibition of other Gram-positive and Gram-negative bacteria and 30% inhibition of Candida albicans growth. The trehalose lipid also showed significant antiadhesive properties against all of the tested microorganisms to polystyrene surface and silicone urethral catheters. The biosurfactant showed 95 and 70% antiadhesive activity against C. albicans and Escherichia coli, respectively. Finally, the role and application of trehalose lipid as an antiadhesive compound was investigated by the modification of the polystyrene and silicone surfaces. The intermolecular interaction energy calculations were performed for investigated complexes at the density functional level of theory. The results indicate that the presence of aromatic moieties can be substantial in the stabilization of trehalose lipid-surface complexes. The antimicrobial and antiadhesive activities of trehalose lipid make them promising alternatives to synthetic surfactants in a wide range of medical applications. Based on our findings, we propose that, because of its ability to inhibit microbial colonization of polystyrene and silicone surfaces, trehalose lipid can be used as a surface coating agent.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Trehalose Lipid Biosurfactant Reduces Adhesion of Microbial Pathogens to Polystyrene and Silicone Surfaces: An Experimental and Computational Approach

et al. 2018

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“…Vecino et al . () investigated the antimicrobial and anti‐adhesive properties of cell‐bound biosurfactants produced by Lactobacillus pentosus (PEB), which are characterized as glycolipid molecules against several micro‐organisms found amongst human skin flora. The performance of PEB was compared against the glycolipids produced by Lactobacillus paracasei (PAB).…”

Section: Health‐related Applicationsmentioning

confidence: 99%

“…While the majority of biosurfactant-related work is focussed on biosurfactants that are produced extracellularly by micro-organisms much less work has been carried out on cell-bound biosurfactants many of which are produced by, for example, probiotic Lactobacilli strains which have the added advantage of being nontoxic, biodegradable and environmentally friendly (Satpute et al 2016b). Vecino et al (2018) investigated the antimicrobial and anti-adhesive properties of cell-bound biosurfactants produced by Lactobacillus pentosus (PEB), which are characterized as glycolipid molecules against several micro-organisms found amongst human skin flora. The performance of PEB was compared against the glycolipids produced by Lactobacillus paracasei (PAB).…”

Section: Dermatological Applicationsmentioning

confidence: 99%

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

et al. 2019

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Synthetic surfactants are becoming increasingly unpopular in many applications due to previously disregarded effects on biological systems and this has led to a new focus on replacing such products with biosurfactants that are biodegradable and produced from renewal resources. Microbially derived biosurfactants have been investigated in numerous studies in areas including: increasing feed digestibility in an agricultural context, improving seed protection and fertility, plant pathogen control, antimicrobial activity, antibiofilm activity, wound healing and dermatological care, improved oral cavity care, drug delivery systems and anticancer treatments. The development of the potential of biosurfactants has been hindered somewhat by the myriad of approaches taken in their investigations, the focus on pathogens as source species and the costs associated with large‐scale production. Here, we focus on various microbial sources of biosurfactants and the current trends in terms of agricultural and biomedical applications.

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“…However, very limited research exists regarding the application of biosurfactants in the pharmaceutical industry. Related to the applications of biosurfactants in these two last areas, some researchers have observed an antimicrobial activity of several biosurfactants against pathogenic strains [9][10][11]. Additionally, researchers have discovered that a biosurfactant obtained from corn steep liquor (CSL) exhibits sunscreen protective properties [12].…”

Section: Introductionmentioning

confidence: 99%

The effect of the presence of biosurfactant on the permeation of pharmaceutical compounds through silicone membrane

Rodríguez‐López

Shokry

Cruz

et al. 2019

Colloids and Surfaces B: Biointerfaces

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The permeation of ten model drugs through silicone membrane was analysed to investigate the effect of the presence of a biosurfactant obtained from corn steep liquor. The ten selected pharmaceutical compounds were chosen to include a diverse range of physicochemical properties, such as variable hydrophobicities, pKa's, molecular masses and degrees of ionisation. When compared with compound permeation alone, the additional inclusion of biosurfactant in the donor phase altered the rate and extent of permeation. It significantly enhanced permeation for five of the compounds, whereas it decreased permeation for four of the compounds and remained approximately the same for the tenth compound. These effects were observed at both biosurfactant concentrations considered, namely 0.005 mg/mL, i.e. below the critical micellar concentration (CMC) and 0.500 mg/mL, i.e. above the CMC of the biosurfactant. Upon analysing permeation change with respect to physicochemical properties of the compounds, it was determined that compounds with a relative molecular mass below 200 resulted in an increase in permeation with biosurfactant present, and those above 200 resulted in a decrease in permeation with biosurfactant present. This effect was therefore attributed to the formation of a drug-biosurfactant interaction that enhanced permeation of smaller compounds, yet retarded permeation for those with a higher molecular mass. These in vitro findings can be considered an indication of potential novel formulation options that incorporate biosurfactant to create transdermal products that have bespoke permeation profiles.

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Bioactivity of glycolipopeptide cell-bound biosurfactants against skin pathogens

Cited by 64 publications

References 33 publications

Trehalose Lipid Biosurfactant Reduces Adhesion of Microbial Pathogens to Polystyrene and Silicone Surfaces: An Experimental and Computational Approach

Trehalose Lipid Biosurfactant Reduces Adhesion of Microbial Pathogens to Polystyrene and Silicone Surfaces: An Experimental and Computational Approach

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

The effect of the presence of biosurfactant on the permeation of pharmaceutical compounds through silicone membrane

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