Bioactivity of Honey and Propolis of Tetragonula laeviceps in Thailand

Chanchao, Chanpen

doi:10.1007/978-1-4614-4960-7_36

Cited by 11 publications

(11 citation statements)

References 32 publications

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“…We suggested that effects of honey on breast cancer (MCF-7) may be its antagonizes estrogen activity, inhibits cell proliferation, induces apoptosis, reduces mitochondrial membrane potential [38][39][40]. As liver cancer (Hep-G2) its Inhibits cell proliferation, suppresses angiogenesis, induces apoptosis, protects against mutagen-induced DNA damage [41][42][43][44][45][46] and colorectal cancer (Caco-2) its Inhibits cell proliferation, induces apoptosis, arrests cell cycle, reduces mitochondrial membrane potential, increases generation of reactive oxygen species, depletes intracellular non-protein thiols, induces DNA damage, and suppresses inflammation [47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Evaluate the cytotoxic activity of honey, propolis, and bee venom from different localities in Egypt against liver, breast, and colorectal cancer

Badria¹,

Fathy²,

Fatehe³

et al. 2017

J Apither

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Introduction: Cancer is a large group of disorders characterized by uncontrolled cellular proliferation. It is one of the most devastating diseases all over the world. Recently, there is an increased interest in the clinical use of natural products as a safe, efficient, and economic therapeutic alternative. Honey bee products therapy, apitherapy, was used to control various diseases including cancer. Objectives: The primary objective of this study was to screen potential cytotoxic effects of honey bee products against different cancer types. Materials and Methods: Samples of honey, venom and propolis were collected from different Egyptian localities with different techniques and tested by MTT cell-based assay against liver (HeP-G2), breast (MCF-7), and colorectal (Caco-2) cancer cell lines. Results: The results showed that, Italian dissected method-bee venom was the most active among all the tested samples against Hep-G2 (93.92%), Caco-2 (93.92%) and MCF-7 (90.17%). However, Libyan propolis proved to be most active among all tested propolis samples. On the other hand, all tested honey samples showed non-remarkable activities except Asyut-clover honey (49.84% against Caco-2 cell line). Conclusion: The results showed that, bee venom, propolis and honey are interesting agents that have valuable activities against Hep-G2, Caco-2 and MCF-7 with bee venom being the most effective agent that might be incorporated in cancer remedy regimens after further studies.

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Section: Discussionmentioning

confidence: 99%

Evaluate the cytotoxic activity of honey, propolis, and bee venom from different localities in Egypt against liver, breast, and colorectal cancer

Badria¹,

Fathy²,

Fatehe³

et al. 2017

J Apither

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“…The mixture was also found to induce apoptosis in HepG2 cells. Antiproliferative effect of Thailand pot-honey on HepG2 cells has also been demonstrated [52].…”

Section: Effects Of Honey On the Development And Progression Of Tumentioning

confidence: 99%

Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer

2014

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Honey is a natural product known for its varied biological or pharmacological activities-ranging from anti-inflammatory, antioxidant, antibacterial, antihypertensive to hypoglycemic effects. This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. It reviews available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. In contrast, limited but promising data are available for other forms of cancers including prostate, bladder, endometrial, kidney, skin, cervical, oral and bone cancer cells. The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. Honey is highly cytotoxic against tumor or cancer cells while it is non-cytotoxic to normal cells. The data indicate that honey can inhibit carcinogenesis by modulating the molecular processes of initiation, promotion, and progression stages. Thus, it may serve as a potential and promising anticancer agent which warrants further experimental and clinical studies.

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“…Stingless bee nests are typically oval-shaped, and can be categorized into egg pots and food pots (Roubik, 2006). T. laeviceps produces less honey than honey bee species (Chanchao, 2013). However, stingless bees produce up to six-times more propolis than honey bees produce, to compensate for their stingless attributes (Kothai and Jayanthi, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that propolis and honey produced by stingless bees have therapeutic effects due to their bioactive components. Therefore, propolis and honey produced by stingless bees are regarded as high economic value products (Chanchao, 2013). It has been reported in the literature that the antioxidant and phenolic content of the propolis produced by stingless bees is higher than that of the propolis produced by honey bees (Muruke, 2014).…”

Section: Introductionmentioning

confidence: 99%

Production of propolis and honey from Tetragonula laeviceps cultivated in Modular Tetragonula Hives

Abduh

Adam

Fadhlullah

et al. 2020

Heliyon

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Propolis and honey produced by stingless bees are regarded as high economic value products due to their bioactive components, which are significantly influenced by conditions at the cultivation location. This study investigated the effect of cultivation location on the amount and quality of propolis and honey produced by Tetragonula laeviceps cultivated in Modular Tetragonula Hives. Fifteen bee colonies were cultivated for at least three months in coffee plantations at two different locations, namely Cibodas and Cileunyi Wetan, Indonesia. The propolis was harvested from the hives and then evaluated to compare product quality from each location. The average production of propolis in both locations was found to lie in the range of 4.26-4.54 g/colony/month with a flavonoid content of 11.4-14.8 mg/g qE. Meanwhile, the average production of honey in both locations after eight months of cultivation was found to lie in the range of 0.93-1.44 g/colony/month. The vitamin C content of the honey obtained from both locations was 17.2-69.5 mg/100 g with an IC 50 of 1188-1341 mg/L, in terms of its ability to inhibit the free radical 2,2-diphenyl-2-picrylhydrazyl. This study shows that cultivation of stingless bees on a coffee plantation in the studied locations has the potential to provide sustainable production of propolis and honey from T. laeviceps.

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Bioactivity of Honey and Propolis of Tetragonula laeviceps in Thailand

Cited by 11 publications

References 32 publications

Evaluate the cytotoxic activity of honey, propolis, and bee venom from different localities in Egypt against liver, breast, and colorectal cancer

Evaluate the cytotoxic activity of honey, propolis, and bee venom from different localities in Egypt against liver, breast, and colorectal cancer

Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer

Production of propolis and honey from Tetragonula laeviceps cultivated in Modular Tetragonula Hives

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