Bioactivity of secoiridoid glycosides from Centaurium erythraea

Kumarasamy, Yashodharan; Nahar, Lutfun; Cox, Philip; Jaspars, Marcel; Sarker, Satyajit D.

doi:10.1078/094471103322004857

Cited by 131 publications

(69 citation statements)

References 19 publications

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“…У рослинах фенольні спо-луки містяться у вільному стані або у вигляді глікозидів. На сьогоднішній день доведені ан-тиоксидантні, протизапальні, адаптогенні вла-стивості фенольних сполук рослинного походжен-ня та їх здатність підвищувати міцність капі-лярів [6][7][8].…”

Section: аналіз останніх дослідженьunclassified

Qualitative composition determination of the biologically active compounds in raw material of Centaurium erythraea Rafn. and Centaurium pulchellum (Sw.) Druce herb by liquid chromatographymass spectrometry method

Proskurova

Gubar

Georgiyants

2017

Upr. ekon. zabezp. âkostì farm.

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Section: аналіз останніх дослідженьunclassified

Qualitative composition determination of the biologically active compounds in raw material of Centaurium erythraea Rafn. and Centaurium pulchellum (Sw.) Druce herb by liquid chromatographymass spectrometry method

Proskurova

Gubar

Georgiyants

2017

Upr. ekon. zabezp. âkostì farm.

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“…The pharmacological activity of C. erythraea is due mainly to the presence of bitter secoiridoid glycosides such as gentiopicroside, sweroside and swertiamarin. They show fungistatic, antibacterial, choleretic, pancreatic and hepatoprotective activities (Kumarasamy et al, 2003). Due to their bitterness, these secoiridoids are also used in the manufacture of some commercial beverages or soft drinks (Vágnerova, 1992).…”

Section: Infection Of Sensitive Dicotyledonous Plants Bymentioning

confidence: 99%

Encapsulation of Centaurium Erythraea Rafn – An Efficient Method for Regeneration of Transgenic Plants

Piątczak¹,

Wysokińska²

2013

Acta Biologica Cracoviensia Series Botanica

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An effective procedure for producing transformed Centaurium erythraea plants from synthetic seeds is described. Explants were encapsulated in 3% sodium alginate with 3% sucrose. Encapsulated hairy roots were cultured on half-strength Murashige and Skoog (1/2 MS) or Woody Plant (WPM) agar-solidified regeneration media supplemented with 6-benzylaminopurine (BAP) or without the cytokinin. The use of WPM with 0.5 mg/L of BAP gave the best shoot formation frequency (86%) and mean number of shoots (15) per root segment. Shoots rooted with 97% frequency on 1/2 MS without growth regulators. Encapsulated shoot buds were cultured on onethird-strength MS agar medium (1/3 MS) supplemented with indole-3-butyric acid (IBA) (0.05 mg/L). The plantlet conversion frequency was 32%. The encapsulated hairy roots and shoot buds were stored for 4, 6 or 14 weeks at 4°C. Synthetic seeds encapsulated with 3% sodium alginate with 3% sucrose stored at 4°C remained viable for 6 weeks but their developmental parameters significantly decreased. Adding nutrient medium and growth regulator to the alginate matrix increased plantlet recovery from both non-stored and stored synthetic seeds: synthetic seeds retained their viability and ability to form plantlets even after 14 weeks of storage. Regenerated transformed plantlets of C. erythraea were acclimatized in the greenhouse.K Ke ey y w wo or rd ds s: : Centaurium erythraea, hairy roots, transgenic plants, synthetic seeds.

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“…10) Sweroside (2) inhibits the growth of Staphylococcus epidermidis. Both swertiamarin (1) and sweroside (2) inhibit the growth of Bacillus cereus, Bacillus subtilis and Citrobacter freundii, are generally toxic in the brine shrimp lethality bioassay, 11) and have mild hepatoprotective activity. 12) Amarogentin (4) is the most bitter principle and it has antiproliferative and pro-apoptotic actions.…”

Section: )mentioning

confidence: 99%

Qualitative and Quantitative Analysis of Swertia Herbs by High Performance Liquid Chromatography-Diode Array Detector-Mass Spectrometry (HPLC-DAD-MS)

Wang

Tang

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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We evaluated the composition of Swertia herbs using high performance liquid chromatography-diode array detector-mass spectrometry (HPLC-DAD-MS). Eleven peaks of 6 species were unequivocally identified by comparing their retention times, UV spectra, on-line electrospray ionization mass (ESI-MS) spectra, and collision-induced dissociation mass spectrometry/mass spectrometry (CID-MS/MS) data with those of authentic compounds. We adopted wavelengths of 254 nm, 340 nm and 230 nm to simultaneously determine these 11 compounds. By comparing the overall DAD and total ion current (TIC) profiles of various samples, the 6 species were differentiated in terms of the occurrence and/or relative concentrations of the eleven compounds. Our novel validated HPLC-DAD-MS method not only facilitates quality control and identification of Swertia herbs, but is also applicable to systematic investigations of the distribution of secoiridoids, flavonoids, and xanthones in the genus Swertia.

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Bioactivity of secoiridoid glycosides from Centaurium erythraea

Cited by 131 publications

References 19 publications

Qualitative composition determination of the biologically active compounds in raw material of Centaurium erythraea Rafn. and Centaurium pulchellum (Sw.) Druce herb by liquid chromatographymass spectrometry method

Qualitative composition determination of the biologically active compounds in raw material of Centaurium erythraea Rafn. and Centaurium pulchellum (Sw.) Druce herb by liquid chromatographymass spectrometry method

Encapsulation of Centaurium Erythraea Rafn – An Efficient Method for Regeneration of Transgenic Plants

Qualitative and Quantitative Analysis of Swertia Herbs by High Performance Liquid Chromatography-Diode Array Detector-Mass Spectrometry (HPLC-DAD-MS)

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