Bioadhesive Films as Drug Delivery Systems

Singh, Inderbir; Debabrata, G. Dastidar; Ghosh, Dipanjan; Abhijit, Sengupta; Tolulope, O. Ajala; Akinsete, Oluwatoyin; Bineet, P. Singh; Madhu, Sharma

doi:10.2174/2210303110999201105154422

Cited by 8 publications

(4 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can result in poor retention and reduced efficacy of drug delivery systems and biomedical devices [ 143 ]. Poor bioadhesion is a common challenge associated with unmodified polymers used in drug delivery systems [ 144 ]. Unmodified PLGA nanoparticles have been found to have poor mucoadhesive properties, which can limit their effectiveness in mucosal drug delivery applications [ 145 ].…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems

Bhatt,

Kumar,

Subramaniyan

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Natural polymers have attracted significant attention in drug delivery applications due to their biocompatibility, biodegradability, and versatility. However, their surface properties often limit their use as drug delivery vehicles, as they may exhibit poor wettability, weak adhesion, and inadequate drug loading and release. Plasma treatment is a promising surface modification technique that can overcome these limitations by introducing various functional groups onto the natural polymer surface, thus enhancing its physicochemical and biological properties. This review provides a critical overview of recent advances in the plasma modification of natural polymer-based drug delivery systems, with a focus on controllable plasma treatment techniques. The review covers the fundamental principles of plasma generation, process control, and characterization of plasma-treated natural polymer surfaces. It discusses the various applications of plasma-modified natural polymer-based drug delivery systems, including improved biocompatibility, controlled drug release, and targeted drug delivery. The challenges and emerging trends in the field of plasma modification of natural polymer-based drug delivery systems are also highlighted. The review concludes with a discussion of the potential of controllable plasma treatment as a versatile and effective tool for the surface functionalization of natural polymer-based drug delivery systems.

show abstract

Section: Challenges and Future Directionsmentioning

confidence: 99%

Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems

Bhatt,

Kumar,

Subramaniyan

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Drug-drug interactions can occur when drug-metabolizing enzymes are inhibited or activated, leading to higher or lower drug levels (Hines, 2013). been reported as reasons for not being able to deliver medication as prescribed (Matsui, 2007;Malkawi et al, 2022;Singh et al, 2021).…”

Section: Pharmacokineticsmentioning

confidence: 99%

Mucoadhesive Drug Delivery Systems for Pediatric and Geriatric Patients

RAİ,

RAWAT,

RATHİ

et al. 2023

Fabad J Pharm Sci

View full text Add to dashboard Cite

A mucoadhesive drug delivery system (MDDS) has been a smart approach to the delivery of drugs at the target site. In MDDS mucus membrane and type of polymer plays an important role in the mucoadhesion phenomenon. To explain the mechanism behind mucoadhesion, various theories have been proposed such as electronic, adsorption, wetting, diffusion, and fracture theory. MDDS has been beneficial to some special patients, preferably pediatric and geriatric. Several challenges such as taste masking, dose determination, dosage form spitting, target delivery, the bioavailability of the drug, adverse drug reaction, toxicity, etc. are faced while developing any delivery system for these special patient populations. Keeping these challenges in mind several researchers have attempted to design and formulate MDDS according to their convenience. The current review focuses on a basic overview of mucoadhesion, various theories of mucoadhesion, and mucoadhesive polymers. The later part of the review focuses on the MDDS for pediatric and geriatric patients with their significance. Various patented formulations and clinical trials going on for these populations have also been discussed.

show abstract

“…In order to treat local conditions of ano-rectal pruritus, inflammation, the pain and discomfort associated with hemorrhoids, semi-solid rectal dosage forms are used, which provide better retention time in the rectum as compared to other dosage forms, and reduce patient compliance issues and increase the drug release [ 7 ].…”

Section: Factors Influencing Rectal Drug Deliverymentioning

confidence: 99%

Advancements in Rectal Drug Delivery Systems: Clinical Trials, and Patents Perspective

et al. 2022

View full text Add to dashboard Cite

The rectal route is an effective route for the local and systemic delivery of active pharmaceutical ingredients. The environment of the rectum is relatively constant with low enzymatic activity and is favorable for drugs having poor oral absorption, extensive first-pass metabolism, gastric irritation, stability issues in the gastric environment, localized activity, and for drugs that cannot be administered by other routes. The present review addresses the rectal physiology, rectal diseases, and pharmaceutical factors influencing rectal delivery of drugs and discusses different rectal drug delivery systems including suppositories, suspensions, microspheres, nanoparticles, liposomes, tablets, and hydrogels. Clinical trials on various rectal drug delivery systems are presented in tabular form. Applications of different novel drug delivery carriers viz. nanoparticles, liposomes, solid lipid nanoparticles, microspheres, transferosomes, nano-niosomes, and nanomicelles have been discussed and demonstrated for their potential use in rectal administration. Various opportunities and challenges for rectal delivery including recent advancements and patented formulations for rectal drug delivery have also been included.

show abstract

Bioadhesive Films as Drug Delivery Systems

Cited by 8 publications

References 98 publications

Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems

Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems

Mucoadhesive Drug Delivery Systems for Pediatric and Geriatric Patients

Advancements in Rectal Drug Delivery Systems: Clinical Trials, and Patents Perspective

Contact Info

Product

Resources

About