Bioadhesive Nanoparticles as Potent Drug Delivery Carriers

Abstract

Background: Last years, nanotechnology-based systems have gained the interest of numerous scientists, especially for biomedical applications. Then, as called, nanocarriers present tunable abilities, can be easily functionalized to target specific epithelial cells, tissues, and organs while various materials can be chosen and generate nanosized particles. At the present, nanoparticles that possess bioadhesion have been studied as potent drug carriers since they can easier penetrate and target organs. Objective: Aim of this study was to explore the various applications of the bioadhesive nanoparticles found in the literature. Methods: Authors have studied the literature finding that bioadhesive nanoparticles can be administered via routes such as oral, topical, ocular, dermal, vaginal, etc according to the clinician’s opinion and treatment choice. Therefore, the knowledge of general characteristics of bioadhesive nanoparticles, the bioadhesion theory, and other properties of nanoparticles should be known for the development of innovative bioadhesive drug nanocarriers. Results: In this review article, the authors state the current knowledge of bioadhesion theories. In addition, the present categories of nanoparticles and their basic characteristics are also discussed. Finally, the biomedical applications of bioadhesive nanocarriers and the several administration routes are extensively reviewed. Conclusion: The review article aims to cover the most current bioadhesive nanoparticles for drug delivery to assist any scientist who desires to study or develop innovative bioadhesive formulations.