Bioadhesive Polymers That Reduce Adhesion Formation

Bengmark, S

doi:10.1007/978-1-4612-1194-5_40

Cited by 2 publications

(2 citation statements)

References 102 publications

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“…Chitosan‐based materials such as carboxymethyl chitosans19, 20 or chitosan/alginate mixtures21 have been considered in patents as potential postsurgical adhesion barrier materials. However, there is little published on this application of chitosan outside of the patent literature 19–22. One patent claimed that postsurgical lavage with N , O ‐carboxymethyl chitosan significantly reduced adhesions in a rat cecal abrasion model 20.…”

Section: Introductionmentioning

confidence: 99%

Peritoneal application of chitosan and UV‐cross‐linkable chitosan

Yeo

Burdick

Highley

et al. 2006

J Biomedical Materials Res

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The suitability of chitosan and UV-cross-linkable chitosan for intraperitoneal use, for example as a barrier device for preventing peritoneal adhesions or for drug delivery, was examined. In vitro experiments using two major cell types present in the peritoneal cavity (mesothelial cells and peritoneal macrophages) revealed neither attractive interactions between cross-linked chitosan gels and the cells nor a proliferative effect. However, the same UV-cross-linked chitosan applied in the peritoneal cavity of rabbits caused a granulomatous reaction with adhesion formation within two weeks in all animals, which persisted up to 4 weeks after exposure. Unmodified chitosan also caused adhesions, while UV irradiation did not. UV-cross-linkable chitosan induced significant elevations in MIP-2 and TNF-alpha from peritoneal macrophages, suggesting that soluble mediators could play a role in inducing adhesion formation. These results reinforce the view that the predictive value of in vitro cytotoxicity assays in matters of biocompatibility may not be sufficient, and suggest that other assays such as cytokine levels may be of value in predicting outcomes in situations involving multiple cell types (i.e. in vivo).

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Section: Introductionmentioning

confidence: 99%

Peritoneal application of chitosan and UV‐cross‐linkable chitosan

Yeo

Burdick

Highley

et al. 2006

J Biomedical Materials Res

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show abstract

“…It has recently been suggested that 'one common complication (bacterial infection) facilitates the occurrence of another common complication (venous thrombosis) by synergistic stimulation of the coagulation system' ( Van der Poll et al, 1998), both conditions being associated with the common clinical praxis of parenteral nutrition (PN). Furthermore, formation of fibrous adhesions occurs in the peritoneum, pericardium and pleura in more than 90% of surgical patients, and is still the main cause of reoperations, intestinal obstructions and female infertility (Bengmark, 2000a). Western lifestyle is most likely responsible for an exaggerated and prolonged APR in connection with trauma and surgery, and there are reasons to believe that the three conditions, nosocomial infections, thrombosis and adhesion formation, are all associated with our lifestyle, and thus should be possible to control -see Bengmark (2000b, c).…”

Section: Nosocomial Infection Rate Remains Highmentioning

confidence: 99%

Prospects for New and Rediscovered Therapies: Probiotics and Phage

Bengmark

2000

Fighting Infection in the 21st Century

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Bioadhesive Polymers That Reduce Adhesion Formation

Cited by 2 publications

References 102 publications

Peritoneal application of chitosan and UV‐cross‐linkable chitosan

Peritoneal application of chitosan and UV‐cross‐linkable chitosan

Prospects for New and Rediscovered Therapies: Probiotics and Phage

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