Bioanalysis and pharmacokinetics of chitosan ester in rabbit serum by HPLC with postcolumn fluorescence derivatization

Yue-hong, Han; Lv, Zhihua; Jiang, Tianyue; Wang, Yuanhong

doi:10.1016/j.jchromb.2006.07.058

Cited by 16 publications

(8 citation statements)

References 15 publications

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“…After a single intravenous bolus injection of BR-AEA (0.1 mg/kg), we monitored the drug concentration in plasma for 24 h ( Figure 3). As can be seen for this compound and others, 24 the concentration-time data from rabbit plasma fitted a two-compartment open model. The calculated pharmacokinetic parameters of BR-AEA are listed in Table 2, which shows that BR-AEA has a greater half-life (t 1/2 ) than salbutamol.…”

Section: Pharmacokinetics Study Of Br-aea In Rabbitssupporting

confidence: 64%

“…The conformational binding site for BR-AEA is in a position that is not favorable for the addition of a sulfate from 3′-phosphoadenosine 5′-phosphosulfate (PAPS) (Figure 5), the last amino acid demonstrated to govern the substrate selectivity of this enzyme. 24 Consequently, these structural differences of BR-AEA at the binding site of all SULTs suggest its low or null metabolism. In similar form, BR-AEA interacted by hydrogen bonds with Tyr240 on SULT1A1 and with Asp60 on SULT1C1.…”

Section: Molecular Modelingmentioning

confidence: 99%

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Pharmacokinetic parameters and a theoretical study about metabolism of BR-AEA (a salbutamol derivative) in rabbit

Soriano-Ursúa¹,

Correa‐Basurto²,

Romero-Huerta³

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Pharmacokinetics Study Of Br-aea In Rabbitssupporting

confidence: 64%

Section: Molecular Modelingmentioning

confidence: 99%

Pharmacokinetic parameters and a theoretical study about metabolism of BR-AEA (a salbutamol derivative) in rabbit

Soriano-Ursúa¹,

Correa‐Basurto²,

Romero-Huerta³

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…The application of bioassay methods, such as enzyme-linked immunosorbent assay (ELISA) techniques, has been limited to pharmaceutical analysis because of the absence of specifi c ligand recognition (Mizuno et al, 2009;Tokita et al, 2010). High performance liquid chromatography (HPLC) methods with post-column fl uorescence derivatization using guanidine as a fl uorometric detection reagent have been developed for the determination of numerous materials, including dermatan sulfate, oversulfated dermatan sulfate, oligomannuronic acid, chitosan and several other carbohydrates (Honda, 1996;Huang et al, 1996;Han et al, 2007;Sun et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica

Zhang

Sun²,

Zhao

et al. 2015

Chin. J. Ocean. Limnol.

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A rapid, sensitive and reproducible high performance liquid chromatography (HPLC) method with post-column fl uorescence derivatization has been developed to determine the amount of low-molecularweight sulfated polysaccharide (GFS) in vivo . The metabolism of GFS has been shown to fi t a two component model following its administration by intravenous injection, and its pharmacokinetic parameters were determined to be as follows: half-time of distribution phase ( t 1/2α )=11.24±2.93 min, half-time of elimination phase ( t 1/2β )=98.20±25.78 min, maximum concentration ( C max )=110.53 μg/mL and peak time ( T max )=5 min. The pharmacokinetic behavior of GFS was also investigated following intragastric administration. However, the concentration of GFS found in serum was too low for detection, and GFS could only be detected for up to 2 h after intragastric administration (200 mg/kg body weight). Thus, the bioavailability of GFS was low following intragastric administration because of the metabolism of GFS. In conclusion, HPLC with postcolumn derivatization could be used for quantitative microanalysis and pharmacokinetic studies to determine the presence of polysaccharides in the serum following intravenous injection.

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“…There are several methods available for CTS detection [12][13][14][15]. However, the results were not satisfactory.…”

Section: Introductionmentioning

confidence: 99%

Resonance Rayleigh scattering method for highly sensitive detection of chitosan using aniline blue as probe

Zhang

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Bioanalysis and pharmacokinetics of chitosan ester in rabbit serum by HPLC with postcolumn fluorescence derivatization

Cited by 16 publications

References 15 publications

Pharmacokinetic parameters and a theoretical study about metabolism of BR-AEA (a salbutamol derivative) in rabbit

Pharmacokinetic parameters and a theoretical study about metabolism of BR-AEA (a salbutamol derivative) in rabbit

Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica

Resonance Rayleigh scattering method for highly sensitive detection of chitosan using aniline blue as probe

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