Bioanalytical challenge: A review of environmental and pharmaceuticals contaminants in human milk

Lopes, Bianca Rebelo; Barreiro, Juliana Cristina; Cass, Quézia B.

doi:10.1016/j.jpba.2016.06.012

Cited by 22 publications

(12 citation statements)

References 111 publications

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“…Because of high fat content in milk, currently it may be difficult to eliminate from it such lipophilic compounds as dioxins: polychlorinated dibenzo-dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) (Lopes et al 2016 ). The last mentioned group—PCBs—is one of the main topics discussed in this paper.…”

Section: Organic Pollutants In Milkmentioning

confidence: 99%

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The impact of environmental pollution on the quality of mother's milk

Pajewska-Szmyt

Sinkiewicz–Darol

Gadzała‐Kopciuch

2019

Environ Sci Pollut Res

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Breastfeeding is a gold standard of neonate nutrition because human milk contains a lot of essential compounds crucial for proper development of a child. However, milk is also a biofluid which can contain environmental pollution, which can have effects on immune system and consequently on the various body organs. Polychlorinated biphenyls are organic pollutants which have been detected in human milk. They have lipophilic properties, so they can penetrate to fatty milk and ultimately to neonate digestive track. Another problem of interest is the presence in milk of heavy metals—arsenic, lead, cadmium, and mercury—as these compounds can lead to disorders in production of cytokines, which are important immunomodulators. The toxicants cause stimulation or suppression of this compounds. This can lead to health problems in children as allergy, disorders in the endocrine system, end even neurodevelopment delay and disorder. Consequently, correlations between pollutants and bioactive components in milk should be investigated. This article provides an overview of environmental pollutants found in human milk as well as of the consequences of cytokine disorder correlated with presence of heavy metals. Graphical abstract

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Section: Organic Pollutants In Milkmentioning

confidence: 99%

“…Human milk monitoring makes it possible to assess the exposure of the mother and the baby. This is a non-invasive way to track environmental pollution (Lopes et al 2016 ; Rebelo and Caldas 2016 ) and it is recommended by WHO.…”

Section: Introductionmentioning

confidence: 99%

The impact of environmental pollution on the quality of mother's milk

Pajewska-Szmyt

Sinkiewicz–Darol

Gadzała‐Kopciuch

2019

Environ Sci Pollut Res

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“…Protein precipitation is an old, simple and commonly used sample pretreatment procedure that allows the reduction of sample complexity. However, it only removes proteins, allowing the remaining of phospholipids, highly present in plasma samples [10,94,95].…”

Section: Quantification Techniquesmentioning

confidence: 99%

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

Pinho

Fortuna

Falcão

et al. 2019

Journal of Pharmaceutical Analysis

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The development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogs, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ingredients require appropriate administration, without the development of adverse effects or toxicity. Therefore, it is required to develop several quantification methods for GLP-1 analogs products, in order to achieve the therapeutic goals, among which ELISA and HPLC arise. These methods are developed, optimized and validated in order to determine GLP-1 analogs, not only in final formulation of the active pharmaceutical ingredient, but also during preclinical and clinical trials assessment. This review highlights the role of ELISA and HPLC methods that have been used during the assessment for GLP-1 analogs, especially for exenatide.

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“…Just to name a few works, theophylline was quantified by high-performance liquid chromatography (HPLC) in urine, saliva and plasma samples [14] alone and, in combination with etophylline, in human plasma [15] , breast milk [16] , [17] and tablets [18] ; paracetamol was quantified by UV–Vis and HPLC in tablets [19] , [20] , [21] , [22] and biological fluids [23] . Reports of HPLC drug determinations as residues in breast milk were found for several drugs [24] , including paracetamol and theophylline [17] , but those methods require extensive pretreatment of samples to remove matrix interference.…”

Section: Introductionmentioning

confidence: 99%

Quantification of theophylline or paracetamol in milk matrices by high-performance liquid chromatography

Fernandes

Aguiar

Fernandes

et al. 2017

Journal of Pharmaceutical Analysis

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A simple, accurate and sensitive high-performance liquid chromatography (HPLC) method was developed, validated and applied to the determination of either theophylline or paracetamol in milk-based samples. The method allowed drug quantification in fresh and powdered milk with a relatively short run time of analysis and it was also successfully applied to the quantification of the drugs in solid dosage forms intended for pediatric use. Moreover, the main significant advantages over other published works are the simplicity of the sample preparation, reduced assay time and sample loss. The method meets the International Conference on Harmonization guideline for analytical methods validation regarding specificity, linearity, accuracy, precision, specificity and robustness as required by health authorities and applied by industry while designing and marketing new drug products. The technique encompasses the separation of the analytes with a reverse phase C18 column under isocratic conditions and UV detection at 272 nm and 243 nm, respectively, for theophylline and paracetamol. The lower limit of quantification for both drugs was determined as 0.2 µg/mL and the between-batch accuracy was approximately 99.7%. This HPLC method allows quantification of theophylline and paracetamol in milk matrices and it can be applied in the design, development and production of milk-based pediatric dosage forms.

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Bioanalytical challenge: A review of environmental and pharmaceuticals contaminants in human milk

Cited by 22 publications

References 111 publications

The impact of environmental pollution on the quality of mother's milk

The impact of environmental pollution on the quality of mother's milk

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

Quantification of theophylline or paracetamol in milk matrices by high-performance liquid chromatography

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