Bioartificial liver support: report of the longest continuous treatment with human hepatocytes

Millis, J. Michael; Cronin, David; Johnson, Robert A.; Conjeevaram, Hari S.; Faust, Thomas W.; Trevino, Sharon; Conlin, C; Brotherton, John D.; Traglia, D; Maguire, Patrick; Danè, Giulia

doi:10.1016/s0041-1345(00)02719-6

Cited by 10 publications

(5 citation statements)

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“…[99] Millis et al used human primary hepatocellular carcinoma cells in a BAL for a clinical treatment of more than 100 h, during which clinical parameters improved the hepatic functions of the patient. [100] Baccarani et al developed a protocol to isolate, cryopreserve and thaw human hepatocytes. [101] The optimization of these 3 steps allowed obtaining a large number of hepatocytes for treating patients affected by ALF.…”

Section: Liver Cell Sourcesmentioning

confidence: 99%

Bioengineering Organs for Blood Detoxification

Legallais

Kim

Mihaila

et al. 2018

Adv Healthcare Materials

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For patients with severe kidney or liver failure the best solution is currently organ transplantation. However, not all patients are eligible for transplantation and due to limited organ availability, most patients are currently treated with therapies using artificial kidney and artificial liver devices. These therapies, despite their relative success in preserving the patients' life, have important limitations since they can only replace part of the natural kidney or liver functions. As blood detoxification (and other functions) in these highly perfused organs is achieved by specialized cells, it seems relevant to review the approaches leading to bioengineered organs fulfilling most of the native organ functions. There, the culture of cells of specific phenotypes on adapted scaffolds that can be perfused takes place. In this review paper, first the functions of kidney and liver organs are briefly described. Then artificial kidney/liver devices, bioartificial kidney devices, and bioartificial liver devices are focused on, as well as biohybrid constructs obtained by decellularization and recellularization of animal organs. For all organs, a thorough overview of the literature is given and the perspectives for their application in the clinic are discussed.

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Section: Liver Cell Sourcesmentioning

confidence: 99%

Bioengineering Organs for Blood Detoxification

Legallais

Kim

Mihaila

et al. 2018

Adv Healthcare Materials

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“…At present, the design requirements of the BAL systems to provide both quality of life and sufficient liver support duration remain unknown. For example, the cell mass and the duration of therapy likely to be required are unknown [6]. The uncertainty in these two parameters makes them important design considerations.…”

Section: Litrature Reviewmentioning

confidence: 99%

“…Recent researchers have addressed the oxygen demand of hepatocytes by incorporating integral oxygenation as in Strathclyde BAL [13], Hanover BAL [14], Goffe and Macdonald devices [15], rather than using in-series oxygenation as with VitaGen ELAD [16] and HepatAssist 2000 [12].…”

Section: Litrature Reviewmentioning

confidence: 99%

Fiber in Fiber (FIF) bioartificial liver device: initial design and prototyping

Hilal‐Alnaqbi¹,

Yousuf²,

Gaylor³

2011

Computer-Aided Design and Applications

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A fiber in fiber (FIF) bioreactor was designed and developed for cell culture to become a bioartificial liver device. The design consists of a conventional hollow fiber cartridge as a cell culture system with the addition of a second set of hollow fibers places within the lumens of the primary set. This arrangement provides three discrete spaces (compartments). A 3D CAD model of the device was developed and used to provide the suitable arrangement of these compartments. Internal and external diameters of the commercially available hollow fibers were studied and chosen. Two configurations of the device were developed and tested. Based on a 3D CAD model, two modules of the device were constructed and studied. Experimental evaluation of small scale FIF improved device prototype were constructed and results from studied quality assurance are also presented. The results showed that the developed bioartificial liver device has an excellent oxygen transfer rate which can improve the achievement of high density cell culture.

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“…Primary human hepatocytes are mostly derived from non-transplantable livers and have already been shown to be safe in human trials [5,10]. However, the major drawback of using primary human cells relates to their availability, because they do function best if isolated and used freshly.…”

Section: Wwwelseviercom/locate/jhepmentioning

confidence: 99%

Bio-artificial liver devices – Tentative, but promising progress

Streetz

2008

Journal of Hepatology

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Bioartificial liver support: report of the longest continuous treatment with human hepatocytes

Cited by 10 publications

References 0 publications

Bioengineering Organs for Blood Detoxification

Bioengineering Organs for Blood Detoxification

Fiber in Fiber (FIF) bioartificial liver device: initial design and prototyping

Bio-artificial liver devices – Tentative, but promising progress

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