Bioartificial materials based on blends of collagen and poly(acrylic acid)

Barbani, Niccoletta; Lazzeri, Luigi; Cristallini, Caterina; Cascone, Maria Grazia; Polacco, Giovanni; Pizzirani, G.

doi:10.1002/(sici)1097-4628(19990516)72:7<971::aid-app13>3.0.co;2-n

Cited by 70 publications

(46 citation statements)

References 9 publications

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“…Moreover, the formation of threedimensional PAA brushes on the originally smooth PET surface increases the effective surface area for biomolecular adsorption. Our result is further supported by the proven electrostatic interaction between PAA and collagen in solution [20]. In addition to acrylic density measurement with Toluidine Blue-O (TBO) method, XPS demonstrates that the relative intensity of the O¼C-O-peak increased significantly on PAA-grafted PET compared with that of the -C-O-peak.…”

Section: Results and Disucssionmentioning

confidence: 99%

Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface

Tan¹,

Teo²,

Liao

et al. 2005

Biomaterials

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Section: Results and Disucssionmentioning

confidence: 99%

Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface

Tan¹,

Teo²,

Liao

et al. 2005

Biomaterials

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“…The gravimetric yield studies were based on the study of Barbani et al in 1999 [29]. Six sample mixtures were prepared by adding 3 ml (0.3 wt%) HA to each and by changing the added SF volume between 0.5-7 ml.…”

Section: Gravimetric Analysismentioning

confidence: 99%

Complex coacervation of silk fibroin and hyaluronic acid

Malay

Bayraktar

Batıgün

2007

International Journal of Biological Macromolecules

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This study aimed to investigate the pH-induced complexation of silk fibroin (SF) and hyaluronic acid (HA). SF-HA complex coacervation was investigated by monitoring turbidity of the SF-HA system under slow acidification. Gravimetric analysis was performed to determine the yield of complex coacervation and viscosity of the system was measured to study the formation of the complexes at different pH values. The influences of total biopolymer concentration and biopolymer weight ratio on complex coacervation were examined during the analyses. Formation of the complexes was evidenced by the minimum viscosity and the maximum turbidity observed in the system. SF-HA complexes were formed within the pH-window of 2.5-3.5 regardless of the total biopolymer concentration or biopolymer ratio. Complex coacervation of SF-HA showed a reversible behavior and coacervation could be handled even in excess amounts of the biopolymers, which pointed out a non-stoichiometric complexation.

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“…Originally, these new materials were conceived to overcome the poor biological performance of synthetic polymers and also to enhance the mechanical characteristics of biopolymers, in order to be employed as biomaterials or as low-environmental impact materials [1][2][3][4][5][6][7] . In this context, our group has investigated several systems involving both biological (primarily fibrin, hyaluronic acid, and collagen) and synthetic components (polyurethanes, poly(vinyl alcohol), and poly(acrylic acid)) [8][9][10][11][12][13] . Reconstituted collagen (CLG) has been used in a wide variety of biomedical applications 14 .…”

Section: Introductionmentioning

confidence: 99%

Bioartificial polymeric materials based on collagen and poly(N-isopropylacrylamide)

Mano

Silva

2007

Mat. Res.

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Films of collagen (CLG) and poly(N-isopropylacrylamide), PNIPAAm, were prepared by casting from water solutions. These bioartificial polymeric materials were studied to examine the influence of PNIPAAm content and glutaraldehyde vapor cross-linking on the thermal and biological stability of CLG. Mixtures, ranging from 20-80 wt% CLG composition, were cross-linked through exposure to glutaraldehyde vapors. Thermal and morphological properties of the films, cross-linked or not, were investigated by differential scanning calorimetry, thermogravimetry, and scanning electron microscopy, with the aim of evaluating miscibility, thermal stability, and interactions among the constituents. The experimental results indicated that the homopolymers are not thermodynamically compatible. However, there is good evidence that effective interactions, probably due to hydrogen bond formation, takes place between the constituents. These interactions are more evident on the samples that were not cross-linked. DSC studies revealed that PNIPAAm exerts a thermal stabilizing effect on uncross-linked CLG, while the cross-linking with glutaraldehyde affects only the biological polymer, preventing the interactions with PNIPAAm. SEM micrographs of the uncross-linked mixtures showed that the morphology, in all compositions studied, remains similar to the pure collagen. In the corresponding cross-linked samples, a more compact aggregation is observed although no appreciably changes can be seen.

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Bioartificial materials based on blends of collagen and poly(acrylic acid)

Cited by 70 publications

References 9 publications

Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface

Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface

Complex coacervation of silk fibroin and hyaluronic acid

Bioartificial polymeric materials based on collagen and poly(N-isopropylacrylamide)

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