Bioassay-Guided Isolation of Antimalarial Triterpenoid Acids from the Leaves of<i>Morinda lucida</i>.

Cimanga, R.K.; Tona, Gaston L.; Mesia, Gauthier K.; Kambu, O.K.; Bakana, Donatien P.; Kalenda, Pascal Dibungi T.; Penge, Auguste O.; Muyembe, Jean-Jacques; Totté, J.; Pieters, Luc; Vlietinck, A. J.

doi:10.1080/13880200601009123

Cited by 59 publications

(44 citation statements)

References 19 publications

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“…Antiplasmodial activity of these two triterpenic acids were also observed on Plasmodium falciparum with IC 50 of 15.2 and 3.1 g/ml (Cimanga et al, 2006) and IC 50 of 9.3 and 4.9 g/ml respectively for oleanolic and ursolic acids (van Baren et al, 2006). Furthermore, they also possess among other activities, interesting anti-inflammatory properties (Recio et al, 1995).…”

Section: Discussionmentioning

confidence: 86%

In vitro antitrypanosomal and antileishmanial activity of plants used in Benin in traditional medicine and bio-guided fractionation of the most active extract

Béro

Hannaert

Châtaigné

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 86%

In vitro antitrypanosomal and antileishmanial activity of plants used in Benin in traditional medicine and bio-guided fractionation of the most active extract

Béro

Hannaert

Châtaigné

et al. 2011

Journal of Ethnopharmacology

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“…Moreover, some of the phytochemicals which have been reported to be active in vivo, exhibited such activities at very high doses that may not be of any meaningful therapeutic use. An example is urosilic acid reported to cause 97.7% chemosuppression in Plasmodium berghei berghei-infected mice but at a dose of 200 mg/kg body weight (Cimanga et al, 2006). Also, many of these compounds have not been tested for their cytotoxicities.…”

Section: Isolated Compounds Characterized As Antimalarials In Nigeriamentioning

confidence: 98%

“…water and ethanol) used for preparation of indigenous medicine. They used solvents such as hexane, methylene chloride, and petroleum ether for extraction Bickii et al, 2000;Goffin et al, 2002;Cimanga et al, 2006), which are not acceptable in indigenous preparation of plant extracts and this, in a way, could affect the results obtained. All publications with respect to antiplasmodial screening here cited have used classical methodologies such as the continuous culture of Plasmodium falciparum strains (Trager and Jensen, 1976); the in vitro antiplasmodial activity tests using radio-isotopic methods (Desjardins et al, 1979) or the microscopic methods; the in vivo antimalarial assays with reference to blood schizonticidal activity of plant extracts called the 4-day suppressive test (Peters, 1965) and Rane (Curative) test similar to that described by Ryley and Peters (1970), using rodent malaria model.…”

Section: Scientific Authentication Of Antimalarial Activities Of Nigementioning

confidence: 99%

Potential antimalarials from Nigerian plants: A review

Adebayo

Krettli

2011

Journal of Ethnopharmacology

226

162

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Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious diseases in many tropical regions, including Nigeria, a West African country where transmission occurs all year round. Many of the inhabitants use plants as remedies against fever and other symptoms of acute malaria, as reported herein. Some of these plants have their antimalarial efficacies scientifically demonstrated and the active compounds isolated with their probable mechanisms of action studied. Medicinal plants are used to treat diseases also where the biodiversity of plants occur in parallel with endemic transmission of malaria. This review focuses on medicinal plants which are used to treat malaria in Nigeria, and on antimalarial testing of extracts and purified compounds from plants. Some show intense activity against malaria parasites in vitro and in experimentally infected mice. The search for new drugs based on plants is important due to the emergence and widespread of chloroquine-resistant and multiple drug-resistant malaria parasites, which require the development of new antimalarials. An acquaintance with antimalarial plants may be a springboard for new phytotherapies that could be affordable to treat malaria, especially among the less privileged native people living in endemic areas of the tropics, mostly at risk of this devastating disease.

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“…As a part of our drug discovery program on anti-malarial agents from Indian medicinal plants, the literature search revealed significant anti-malarial activity in pentacyclic triterpenes, betulinic, oleanolic and ursolic acids [17,18]. This prompted us to investigate anti-malarial activity in other triterpenoids, found in widely used Indian medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

In Silico and In Vivo Anti-Malarial Studies of 18β Glycyrrhetinic Acid from Glycyrrhiza glabra

et al. 2013

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Malaria is one of the most prevailing fatal diseases causing between 1.2 and 2.7 million deaths all over the world each year. Further, development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-malarial agents possessing novel modes of action. Over the past few years triterpenoids from higher plants have shown a wide range of anti-malarial activities. As a part of our drug discovery program for anti-malarial agents from Indian medicinal plants, roots of Glycyrrhiza glabra were chemically investigated, which resulted in the isolation and characterization of 18β-glycyrrhetinic acid (GA) as a major constituent. The in vitro studies against P. falciparum showed significant (IC50 1.69µg/ml) anti-malarial potential for GA. Similarly, the molecular docking studies showed adequate docking (LibDock) score of 71.18 for GA and 131.15 for standard anti-malarial drug chloroquine. Further, in silico pharmacokinetic and drug-likeness studies showed that GA possesses drug-like properties. Finally, in vivo evaluation showed a dose dependent anti-malarial activity ranging from 68–100% at doses of 62.5–250mg/kg on day 8. To the best of our knowledge this is the first ever report on the anti-malarial potential of GA. Further work on optimization of the anti-malarial lead is under progress.

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Bioassay-Guided Isolation of Antimalarial Triterpenoid Acids from the Leaves ofMorinda lucida.

Cited by 59 publications

References 19 publications

In vitro antitrypanosomal and antileishmanial activity of plants used in Benin in traditional medicine and bio-guided fractionation of the most active extract

In vitro antitrypanosomal and antileishmanial activity of plants used in Benin in traditional medicine and bio-guided fractionation of the most active extract

Potential antimalarials from Nigerian plants: A review

In Silico and In Vivo Anti-Malarial Studies of 18β Glycyrrhetinic Acid from Glycyrrhiza glabra

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