Bioatividade de óleos essenciais de sassafrás e eucalipto em cascudinho

Pinto, Airton Rodrigues; Carvalho, Ruy Inácio Neiva de; Netto, Sylvio Péllico; Weber, Saulo Henrique; Souza, Edilaine de; Furiatti, Rui S.

doi:10.1590/s0103-84782010005000026

Cited by 16 publications

(7 citation statements)

References 7 publications

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“…In general, essential oils present significant yield, and their composition can vary depending on climatic and environmental factors, such as temperature, humidity, precipitation, soil, and time of collection. Additionally, the part of the plant used (leaves, bark, seeds or root), as well as the method of the extraction, may interfere with the composition of the essential oil of a given species [15,32,33].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, due to its remarkable chemical constitution and abundance of essential oils, this plant has been used as a source of flavoring agents in the food industry [11][12][13]. Previous research with the essential oil of O. odorifera (EOOO) has identified safrole (C 10 H 10 O 2 ) as a major constituent, with unique chemical and pharmacological properties [14][15][16]. Accordingly, safrole has been used in the production of fragrances and as a raw material in the synthesis of drugs and insecticides [17].…”

Section: Introductionmentioning

confidence: 99%

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GC-MS Profile and Enhancement of Antibiotic Activity by the Essential Oil of Ocotea odorífera and Safrole: Inhibition of Staphylococcus aureus Efflux Pumps

et al. 2020

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Considering the evidence that essential oils, as well as safrole, could modulate bacterial growth in different resistant strains, this study aims to characterize the phytochemical profile and evaluate the antibacterial and antibiotic-modulating properties of the essential oil Ocotea odorífera (EOOO) and safrole against efflux pump (EP)-carrying strains. The EOOO was extracted by hydrodistillation, and the phytochemical analysis was performed by gas chromatography coupled to mass spectrometry (GC-MS). The antibacterial and antibiotic-modulating activities of the EOOO and safrole against resistant strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were analyzed through the broth microdilution method. The EP-inhibiting potential of safrole in association with ethidium bromide or antibiotics was evaluated using the S. aureus 1199B and K2068 strains, which carry genes encoding efflux proteins associated with antibiotic resistance to norfloxacin and ciprofloxacin, respectively. A reduction in the MIC of ethidium bromide or antibiotics was used as a parameter of EP inhibition. The phytochemical analysis identified 16 different compounds in the EOOO including safrole as the principal constituent. While the EOOO and safrole exerted clinically relevant antibacterial effects against S. aureus only, they potentiated the antibacterial activity of norfloxacin against all strains evaluated by our study. The ethidium bromide and antibiotic assays using the strains of S. aureus SA1119B and K2068, as well as molecular docking analysis, indicated that safrole inhibits the NorA and MepA efflux pumps in S. aureus. In conclusion, Ocotea odorifera and safrole presented promising antibacterial and antibiotic-enhancing properties, which should be explored in the development of drugs to combat antibacterial resistance, especially in strains bearing genes encoding efflux proteins.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

GC-MS Profile and Enhancement of Antibiotic Activity by the Essential Oil of Ocotea odorífera and Safrole: Inhibition of Staphylococcus aureus Efflux Pumps

et al. 2020

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“…The experiments were repeated three independent times with 2 plates for each treatment. Were considered dead the insects who showed no reaction to the touch with metallic tweezers (Pinto Junior et al, 2010). The mortality curve was obtained plotting the oil dose applied against the number of death insects, which generate an equation used to calculate the lethal doses (LD 5 , LD 25 , LD 50 and LD 95 ).…”

Section: Evaluation Of Insecticidal Activitymentioning

confidence: 99%

Essential oil of Cinnamodendron dinisii Schwanke for the control of Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae)

Vedovatto

Júnior

Astolfi

et al. 2015

Rev. bras. plantas med.

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ABSTRACT:The use of natural compounds is a less aggressive alternative for the control of insects in stored grains, in relation to synthetic chemical agents. Plants with insecticidal properties can be used as a source of these compounds to the direct application in pest control. In this work, the essential oil of Cinnamodendron dinisii was chemically characterized and tested regarding its insecticidal and repellent effect on the control of Sitophilus zeamais in stored grains. The essential oil was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). The insecticidal potential was evaluated through the maintenance of the insects during 24 hours in contact with several doses of the oil, in the absence of feed substrate. The Bioassays of repellency were conducted with lethal doses (LD 5 , LD 25 , LD 50 and LD 95 ) obtained from insecticidal bioassay. In order to compare the treatments, the preference index (PI) was used. The essential oil of C. dinisii had insecticidal activity against S. zeamais, causing a linear and crescent mortality with LD of 0.04, 0.17, 0.34 and 0.63 µL/cm 2 , respectively. The repellency ranged from 55.4% to 85.2%, using the LD values previously mentioned. The DL 5 was neutral regarding repellence (PI index -0,09), but from DL 25 on, the PI index was between -0.1 and -1.0, indicating repellence activity.Keywords: essential oil, insecticidal, repellence, Sitophilus zeamais. RESUMO: Óleo essencial de Cinnamodendron dinisii Schwanke para controle deSitophilus zeamais Motschulsky (Coleoptera: Curculionidae). O uso de compostos naturais é uma alternativa menos agressiva para o controle de insetos em grãos armazenados em relação aos agentes químicos sintéticos. Plantas com propriedades inseticidas podem ser usadas como fonte destes compostos para a aplicação direta no controle de pragas. No presente trabalho, o óleo essencial de Cinnamodendron dinisii foi caracterizado quimicamente e testado em relação ao seu efeito repelente inseticida no controle de Sitophilus zeamais em grãos armazenados. O óleo essencial foi obtido por hidrodestilação e analisado por cromatografia gasosa-espectrometria de massa (GC-MS). O potencial inseticida foi avaliado pela manutenção dos insetos durante 24 horas em contato com várias doses de óleo, na ausência de substrato alimentar. Os bioensaios de repelência foram realizados com as doses letais (DL 5 , DL 25 , DL 50 e DL 95 ) obtidas do bioensaio inseticida. Para comparar os tratamentos foi utilizado o índice de preferência (PI). O óleo essencial de C. dinisii apresentou atividade inseticida sobre S. zeamais, causando mortalidade linear e crescente com DL de 0,04, 0,17, 0,34 e 0,63 µL/cm 2 , respectivamente. A repelência variou entre 55,4% até 85,2%, utilizando os valores de DL acima mencionados. A DL 5 mostrou-se neutra em relação à repelência (índice PI -0,09), mas a partir de DL 25 o índice PI foi entre -0,1 e -1,0, indicando atividade de repelência.Palavras-chave: óleo essencial, inseticida, repelência, Sitophilus zeamais.

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“…Popularly known as eucalyptus, it comes from Australia and includes more than 600 species that have adapted to various types of climate and soil conditions (Santos et al, 1996). Interest is growing in the use of this EO, such as the control of Rhipicephalus microplus (Olivo et al, 2013), control of Alphitobius diaperinus (Junior et al, 2010), and as a general anaesthetic for fish Rezende et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The anaesthetic efficacy of Eucalyptus globulus essential oil on silver catfish ( Rhamdia quelen )

Silva

Deschamps

Matter

et al. 2021

Aquaculture Research

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Aquaculture handling requires fast anaesthesia, assuming an action-time within 3 min and a recovery time of <5 min. This study aimed to determine the lowest effective concentration (LEC) of eucalyptus (Eucalyptus globulus) essential oil (EEO) administered to Rhamdia quelen and its anaesthetic effects. Analysis of EEO chemical profile showed 1,8-cineole as the main component. Two assays were then carried out. In the first, four concentrations were tested (600, 650, 700 and 750 µl L −1 ). EEO was found to be an effective anaesthetic in R. quelen with LEC of 700 µl L −1 . During this assay, no fish mortality occurred. The second assay evaluated stress. Fish were divided into three groups: control (baseline values, without anaesthetic); eugenol (50 mg L −1 ) and EEO (700 µl L −1 ). In this assay, EEO also inhibited the primary stress response. While cortisol did not increase in the EEO regime, plasma glucose and lactate levels did increase in blood. Meanwhile, eugenol kept all stress indicators equal to those of the control group. Therefore, although EEO has suitable anaesthetic characteristics, it should be used with caution, as it does not prevent changes in plasma glucose and lactate for R. quelen.

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Bioatividade de óleos essenciais de sassafrás e eucalipto em cascudinho

Cited by 16 publications

References 7 publications

GC-MS Profile and Enhancement of Antibiotic Activity by the Essential Oil of Ocotea odorífera and Safrole: Inhibition of Staphylococcus aureus Efflux Pumps

GC-MS Profile and Enhancement of Antibiotic Activity by the Essential Oil of Ocotea odorífera and Safrole: Inhibition of Staphylococcus aureus Efflux Pumps

Essential oil of Cinnamodendron dinisii Schwanke for the control of Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae)

The anaesthetic efficacy of Eucalyptus globulus essential oil on silver catfish ( Rhamdia quelen )

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