Bioavailability and palatability of praziquantel incorporated into solid-lipid nanoparticles fed to yellowtail kingfish Seriola lalandi

Abstract

Bioavailability and palatability of praziquantel incorporated into solid-lipid nanoparticles fed to yellowtail kingfish Seriola lalandi.

Solid Lipid Nanoparticles Administering Antioxidant Grape Seed-Derived Polyphenol Compounds: A Potential Application in Aquaculture

“…Searching for orally approved delivery systems such as solid dispersions [28] and cyclodextrins [29], capable to supply micro and macronutrients for fish growth is still a challenge for fish immunology researchers as. The reason is that, once administered in vivo, some of them can fail, leading to the loss of their cargo prior to target immunocompetent fish cells [30,31]. Among antioxidant agents, the whole GSE mixture has been studied for its beneficial effects on fish cells [3,4], Moreover, even the isolated polyphenols arising from GSE; namely, resveratrol was found to inhibit both lipopolysaccharide-induced and endogenous eicosanoid production [32], and polyphenol-enriched extract was seen to decrease the oxidative stress and extend the life span of medaka fish [33].…”

Praziquantel use in aquaculture – Current status and emerging issues

“…As a result, different methods of including PZQ in feed have been trialled. These include using moist pellets, various methods of incorporating PZQ into feed pellets (mixing with powder, soaking, microencapsulation, use of nanoparticles), coating feed with stimulants or scents (commercial attractants, fish oil, krill extracts, sugar, or fresh garlic), or using coating or binding agents (carboxymethyl cellulose sodium salt, agar, gelatine) ( Williams et al, 2007 ; Yamamoto et al, 2011 ; Blumenthal, 2014 ; Partridge et al, 2014 , 2019 ; Forwood et al, 2016b ; Pilmer, 2016 ). These techniques have had limited success.…”

“…Japanese amberjack and rainbow trout have circulation times of 1.3 min and 1.9 min respectively ( Brill et al, 2008 ), in comparison mice have a blood circulation time of only 15 s ( Debbage et al, 1998 ). This more rapid circulation combined with the fact PZQ undergoes significant first-pass metabolism in the liver has been proposed to explain some of the difference between mammals and fish species ( Partridge et al, 2019 ).…”

“…Oral co-administration of PZQ with cimetidine or in nanoparticles has been trialled to increase PZQ bioavailability. Nanoparticles, despite showing promise in mammalian studies, did not improve bioavailability in yellowtail kingfish ( Partridge et al, 2019 ). Alternatively, cimetidine co-administration led to higher PZQ levels in the blood of rockfish and enhance treatment efficacy against M. sebastis ( Kim et al, 2001b ; Kim and Kim, 2002 ).…”

Effects of Formulation on the Palatability and Efficacy of In-Feed Praziquantel Medications for Marine Finfish Aquaculture

“…Praziquantel (PZQ) is a highly efficacious anthelmintic agent [ 8 , 9 ] against a wide range of platyhelminth parasites, including monogeneans. It is effective when administered to infected fish via injection, bathing, or feeding [ 4 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Injection, however, is impractical in commercially farmed fish, and bathing presents challenges similar to those described above for hydrogen peroxide, with the added disadvantage of discharging relatively large quantities of a pharmacologically active agent into the environment.…”