Bioavailability Enhancement and Targeting of Stomach Tumors Using Gastro-Retentive Floating Drug Delivery System of Curcumin—“A Technical Note”

Shishu,; Gupta, Neeta; Aggarwal, Nidhi

doi:10.1208/s12249-008-9096-y

Cited by 26 publications

(8 citation statements)

References 10 publications

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“…Microporous polymeric materials, or sponges, are attractive for gastroretentive drug delivery applications due to their inherent low-density and flotation properties, and their porous structure, which offers opportunities for achieving efficient drug release. In addition, sponge manufacture generally involves relatively few components and simple procedures compared with other previous floating solid dosage forms such as beads and tablets, for which effervescent materials are needed to provide their floating properties [ 12 , 13 , 22 ]. The incorporation of curcumin-loaded SMEDDS within a floating sponge offers a novel formulation for local treatment of gastrointestinal diseases.…”

Section: Introductionmentioning

confidence: 99%

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

2017

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Alginate-based composite sponges were developed as carriers to prolong the gastric retention time and controlled release of curcumin-loaded self-microemulsifying drug delivery systems (Cur-SMEDDS). Liquid Cur-SMEDDS was incorporated into a solution made up of a mixture of polymers and converted into a solid form by freeze-drying. The ratio of alginate as the main polymer, adsorbent (colloidal silicon dioxide), and additional polymers—sodium carboxymethyl cellulose (SCMC), hydroxypropyl methylcellulose (HPMC)—was varied systematically to adjust the drug loading and entrapment efficiency, sponge buoyancy, and the release profile of Cur-SMEDDS. The optimum composite sponge was fabricated from a 4% alginate and 2% HPMC mixed solution. It immediately floated on simulated gastric fluid (SGF, pH 1.2) and remained buoyant over an 8 h period. The formulation exhibited an emulsion droplet size of approximately 30 nm and provided sustained release of Cur-SMEDDS in SGF, reaching 71% within 8 h compared with only 10% release from curcumin powder. This study demonstrates the potential of alginate-based composite sponges combined with self-microemulsifying formulations for gastroretention applications involving poorly soluble compounds.

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Section: Introductionmentioning

confidence: 99%

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

2017

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“…Many approaches have been undertaken to improve the bioavailability of CUR. Existing pharmaceutical formulation techniques have been employed for CUR, including nanoparticle-based delivery systems, 14 liposomal delivery systems, 15 self-microemulsifying drug delivery systems, 16 gastroretentive floating drug delivery systems, 17 micelles, and phospholipid complexes. 18,19 Although each has made advancements, fundamental and practically significant improvement of oral bioavailability remains an elusive goal.…”

Section: Introductionmentioning

confidence: 99%

A Novel Solubility-Enhanced Curcumin Formulation Showing Stability and Maintenance of Anticancer Activity

Zhang

Koh

Jeansonne

et al. 2011

Journal of Pharmaceutical Sciences

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“…ETO-Cur has been shown to be 7-8 times more bioavailable with superior anti-cancer properties than standard Curcumin. [13][14][15] The Vitamin E family consists of eight distinct isomers-4 tocopherols and 4 tocotrienols [16] Tocotrienols display potent antioxidant, anticancer, anti-inflammatory, neuroprotective and cholesterol-lowering properties. [17][18][19][20][21][22][23] A tocotrienol-rich fraction (TRF), (containing a mixture of isomers) isolated from palm oil has been used as an anti-oxidant and anti-cancer agent.…”

Section: Introductionmentioning

confidence: 99%

Natural agents inhibit colon cancer cell proliferation and alter microbial diversity in mice

et al. 2020

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The current study was undertaken to investigate the effect of differentially formulated polyphenolic compound Essential Turmeric Oil-Curcumin (ETO-Cur), and Tocotrienol-rich fraction (TRF) of vitamin E isomers on colorectal cancer (CRC) cells that produce aggressive tumors. Combinations of ETO-Cur and TRF were used to determine the combinatorial effects of ETO-Cur and TRF-mediated inhibition of growth of CRC cells in vitro and HCT-116 cells xenograft in SCID mice. 16S rRNA gene sequence profiling was performed to determine the outcome of gut microbial communities in mice feces between control and ETO-Cur-TRF groups. Bacterial identifications were validated by performing SYBR-based Real Time (RT) PCR. For metagenomics analysis to characterize the microbial communities, multiple software/tools were used, including Quantitative Insights into Microbial Ecology (QIIME) processing tool. We found ETO-Cur and TRF to synergize and that the combination of ETO-Cur-TRF significantly inhibited growth of HCT-116 xenografts in SCID mice. This was associated with a marked alteration in microbial communities and increased microbial OTU (operation taxonomic unit) number. The relative abundance of taxa was increased and the level of microbial diversity after 34 days of combinatorial treatment was found to be 44% higher over the control. Shifting of microbial family composition was observed in ETO-Cur-TRF treated mice as evidenced by marked reductions in Bacteroidaceae, Ruminococcaceae, Clostridiales, Firmicutes and Parabacteroids families, compared to controls. Interestingly, during the inhibition of tumor growth in ETO-Cur treated mice, probiotic Lactobacillaceae and Bifidobacteriaceae were increased by 20-fold and 6-fold, respectively. The relative abundance of anti-inflammatory Clostridium XIVa was also increased in ETO-Cur-TRF treated mice when compared with the control. Our data suggest that ETO-Cur-TRF show synergistic effects in inhibiting colorectal cancer cell proliferation in vitro and in mouse xenografts in vivo, and might induce changes in microbial diversity in mice.

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Bioavailability Enhancement and Targeting of Stomach Tumors Using Gastro-Retentive Floating Drug Delivery System of Curcumin—“A Technical Note”

Cited by 26 publications

References 10 publications

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems

A Novel Solubility-Enhanced Curcumin Formulation Showing Stability and Maintenance of Anticancer Activity

Natural agents inhibit colon cancer cell proliferation and alter microbial diversity in mice

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