Bioavailability of caffeic acid in rats and its absorption properties in the Caco-2 cell model

Abstract

CA was shown to have low oral bioavailability in rats, low intestinal absorption, and poor permeability across Caco-2 cells.

In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives

“…Many biological activity are attributed to esters derivatives of caffeic acids, such as anti‐inflammatory activity, anti‐cancer by induction of apoptosis, antimicrobial, immunomodulatory, as described in the introductory part of this manuscript. Furthermore, it has been shown previously that caffeic is absorbed in rats and has an absolute bioavailability in humans around 95% . To the best of our knowledge, there are no data available about caffeic acid ethyl ester bioavailability, but a publication showed that caffeic acid phenetyl ester was resorbed in rats .…”

“…Furthermore, it has been shown previously that caffeic is absorbed in rats and has an absolute bioavailability in humans around 95%. [22,23] To the best of our knowledge, there are no data available about caffeic acid ethyl ester bioavailability, but a publication showed that caffeic acid phenetyl ester was resorbed in rats. [24] Caffeic acid and derivatives could then explain, at least in part, the oral antimalarial activity of traditional medicinal plants where these compounds are abundant.…”

Simultaneous determination of thirteen flavonoids from Xiaobuxin-Tang extract using high-performance liquid chromatography coupled with electrospray ionization mass spectrometry

“…Herbal complicated compounds are difficult to be detected due to lower concentration and interference from endogenous compounds in vivo, however, compared to in vivo pharmacokintic study, the experimental conditions of the in situ vascularly perfused rat intestine preparation, such as drug concentration, perfusate flow and the composition of perfusate, can be properly adjusted to survey the effect on the intestinal absorption of the tested drugs [14,18], it is an ideal approach for traditional Chinese medicines (TCM) to investigate the target constituents and enhance their detected concentration. Besides, the in situ vascularly perfused rat intestine preparation is advantageous of that the circulation and morphology of the tissues remain intact, which is precise assessment of the contribution of intestinal absorption of drug [14], and we had successfully investigated intestinal absorption properties of caffeic acid using this method [19]. In this study, we used this method to investigate intestinal absorption of these thirteen flavonoids of XBXT-2 and the in situ experiment date analysis for the intestinal absorption was calculated as follows: Intestinal absorption% = content in perfused/content in 0.2 g XBXT-2 × 100%.…”

Wheat Antioxidants, Their Role in Bakery Industry, and Health Perspective

“…Both in vivo and in vitro studies must be done for accurate determination of engagement and bioavailability of these phenolic acids. It has already been performed for caffeic acid and p-coumaric acid [30,65,66].…”

“…These compounds are present as bound forms, respectively, as phenolic acids (85%) in maize, wheat and maize (75%), and rice (62%). Cinnamic acids have been categorized as bioactive ingredients of the diet because they are bound to structural compounds of the cell wall [30,31]. The schematic representation of wheat grain fractions is shown in Figure 1.…”