Bioavailability of natural carotenoids in human skin compared to blood

Meinke, Martina C.; Darvin, Maxim E.; Vollert, Henning; Lademann, Jürgen

doi:10.1016/j.ejpb.2010.06.004

Cited by 103 publications

(105 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cutaneous carotenoids are lipophilic antioxidants and serve as a superior marker for the antioxidant capacity of the body [58,59]. Carotenoids such as most of the known antioxidants have to be taken up with food, such as fruits and vegetables, because they cannot be produced by the body itself [60,61].…”

Section: Effect Of Orally Ingested Antioxidantsmentioning

confidence: 99%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

Self Cite

View full text Add to dashboard Cite

Organisms produce free radicals which are essential for various metabolic processes (enzymatic oxidation, cellular respiration, signaling). Antioxidants are important chemical compounds that specifically prevent the oxidation of substances by scavenging radicals, especially reactive oxygen species (ROS). Made up of one or two unpaired electrons, ROS are free radicals that are highly reactive and can attack other metabolites. By using electron paramagnetic resonance (EPR) spectroscopy, it is possible to measure paramagnetic substances such as free radicals. Therefore the dermal antioxidant activity can be determined by applying semi-stable radicals onto the skin and measuring the antioxidant-induced radical scavenging activity in the skin. In recent years, EPR has been OPEN ACCESS Cosmetics 2015, 2 287 developed as a spectroscopic method for determining the antioxidant status in vivo. Several studies have shown that an additional uptake of dietary supplements, such as carotenoids or vitamin C in physiological concentrations, provide a protective effect against free radicals. Using the EPR technique it could be demonstrated that the radical production in stress situations, such as irradiation with infrared and visible light, was reduced with time. However, not only the oral uptake of antioxidants, but also the topical application of antioxidants, e.g., a hyperforin-rich cream, is very useful against the development of oxidative stress. Regular application of a hyperforin-rich cream reduced radical formation. The skin lipids, which are very important for the barrier function of the skin, were also stabilized.

show abstract

Section: Effect Of Orally Ingested Antioxidantsmentioning

confidence: 99%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…A high concentration of antioxidants in skin care formulations allows the penetration of the epidermis and dermis. The main advantage of the topical administration when compared to the oral administration to treat and prevent skin conditions is the direct delivery of bioactive substances to the target area, thus eliminating concerns about systemic circulation Page 2 / 10 (Meinke et al, 2010;Palombo et al, 2007). The cutaneous delivery of antioxidants is a complementary and well known treatment to prevent skin aging and to avoid dermal diseases, such as skin cancer (Sander et al, 2004;Pinnell, 2003;Dreher et al, 1998;Lopez-Torres et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications

Chiari-Andréo

Trovatti

Marto

et al. 2017

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Guava (Psidium guajava L.) is a native fruit of the American tropics with commercial applications for its taste, flavor and aroma. Numerous pharmacological uses have been described for it, such as the antiseptic effect of its leaves, the use of the fresh fruit and tea from its leaves for the treatment of diarrhea, dysentery, diabetes mellitus, and others. However, considering its rich composition, the guava also is a potential source of antioxidants to be used in the development of new formulations for cosmetic and/or dermatological applications, the main focus of this research. Herein, we describe the study of the phytochemical composition and the antioxidant activity of a guava extract prepared with non-toxic solvents aiming its use at biological applications. High performance liquid chromatography and mass spectrometry were employed to identify the major components, while thermoanalytical measurements and hot stage microscopy were used to assess the chemical stability of guava fruit extract. The antioxidant activity was also evaluated assessing the SOD-like activity and ABTS free radical scavenger. The results show that the extract is a rich source of phenolic compounds, such as quercetin, kaempferol, schottenol, among many others. All of the components found in guava extract exhibit biological effects according to the literature data, mainly antioxidant properties. Uniterms

show abstract

“…When the level of antioxidant carotenoids in skin is considered as the expression of the global redox balance, 20 our measurements confirm the remarkable oxidative stress of transfusion-dependent thalassemia patients, showing that they had a mean loss of more than 50% of the antioxidant defense. Thalassemia oxidative stress has appeared positively correlated with serum ferritin and liver damage.…”

Section: Discussionmentioning

confidence: 48%

“…The assessment of skin carotenoid status by RRS is now considered valid, feasible and reproducible, 10 and correlated with the blood carotenoid level. [19][20][21] The global body's antioxidant status results from a balance between the level of antioxidants in cells and body fluids, including blood, and pro-oxidant species endogenously produced or coming from external sources. Body's molecular antioxidants work in concert and preserve each other, so the level of each one in the pool reflects the level of the whole antioxidant pool.…”

mentioning

confidence: 99%

Raman Spectroscopy Technology to Monitor the Carotenoids in Skin of Thalassemia Patients: A Novel Non-Invasive Tool Relating Oxidative Stress with Iron Burden

Perrone

Tesoriere

Pintaudi

et al. 2014

Thalassemia Reports

View full text Add to dashboard Cite

In this work we approach the relationship between redox state and iron overload by noninvasive instrumental techniques. Intracardiac, liver iron and liver fibrosis have been monitored in transfusion-dependent thalassemia patients by magnetic resonance imaging and hepatic transient elastography examinations. These measurements have been matched with a non-invasive, and yet unexplored in clinical practice, evaluation of body's oxidative stress through measurement of antioxidant carotenoids in skin, by a spectroscopic method based on Raman technology (RRS). The global body's antioxidant status results from a balance between the level of antioxidants in cells and body fluids, including blood, and pro-oxidant species endogenously produced or coming from external sources. On this basis, the level of skin carotenoids can be considered a biomarker of the entire antioxidant status. In our work the use of RRS method provided information on the redox state of thalassemia patients, which was correlated with the iron status of the patients. Due to the highly adverse effects of accumulated iron, the novel, simple, non-invasive RRS to monitor dermal carotenoids with high compliance of the patients may be a useful tool for the management of thalassemia patients.

show abstract

Bioavailability of natural carotenoids in human skin compared to blood

Cited by 103 publications

References 38 publications

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications

Raman Spectroscopy Technology to Monitor the Carotenoids in Skin of Thalassemia Patients: A Novel Non-Invasive Tool Relating Oxidative Stress with Iron Burden

Contact Info

Product

Resources

About