Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig

Goyarts, Tanja; Dänicke, Sven

doi:10.1016/j.toxlet.2005.10.007

Cited by 147 publications

(122 citation statements)

References 29 publications

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“…In both chicken (Osselaere et al 2013) and turkey (Devreese et al 2015) the DON absorption was low as reflected by the AUC po,plasma, norm = 0.03 l (h*kg) -1 . On the contrary, the absorption appears to be higher in piglets (Prelusky et al 1988) and pigs (Goyarts & Dänicke 2006) as shown by AUC po,plasma,norm = 4.4 and 2.3 l (h*kg) -1 , respectively. Hence, DON toxicokinetics in fish apparently differ to some extent from mammalian and bird species.…”

Section: Toxicokinetics Of Donmentioning

confidence: 89%

“…Interestingly, in salmon fed with high-DON feed, DON accumulated significantly in muscle and liver as a result of a high systemic uptake and relatively slow elimination. In the elimination experiments at the end of the study the half-lives in plasma and muscle were estimated to be higher than 15 h, whereas the plasma t 1/2 's were between 0.5 and 5 h in rodents, birds, pigs, sheep and cows (EFSA 2004a;Goyarts & Dänicke 2006;Wu et al 2010;VKM 2013). Accordingly, DON tissue accumulation has not been found in these species.…”

Section: Toxicokinetics Of Donmentioning

confidence: 99%

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Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar)

Bernhoft

Høgåsen

Rosenlund

et al. 2017

Food Additives & Contaminants: Part A

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Post-smolt Atlantic salmon (Salmo salar) were fed standard feed with added 2 or 6 mg kg -1 pure deoxynivalenol (DON), 0.8 or 2.4 mg kg -1 pure ochratoxin A (OTA), or no added toxins for up to 8 weeks. The experiments were performed in duplicate tanks with 25 fish each per diet group, and the feed was given for three 2-h periods per day. After 3, 6 and 8 weeks, 10 fish from each diet group were sampled. In the following hours after the last feeding at 8 weeks, toxin elimination was studied by sampling three fish per diet group at five time points. Analysis of DON and OTA in fish tissues and plasma was conducted by liquid chromatography-mass spectrometry and high-pressure liquid chromatography with fluorescence detection, respectively. DON was distributed to the liver, kidney, plasma, muscle, skin and brain, and the concentrations in liver and muscle increased significantly from 3 to 8 weeks of exposure to the high-DON diet. After the last feeding at 8 weeks, DON concentration in liver reached a maximum at 1 h and decreased thereafter with a half-life (t 1/2 ) of 6.2 h. DON concentration in muscle reached a maximum at 6 h and was then eliminated with a t 1/2 = 16.5 h. OTA was mainly found in liver and kidney, and the concentration in liver decreased significantly from 3 to 8 weeks in the high-OTA group. OTA was eliminated faster than DON from various tissues. By using Norwegian food consumption data and kinetic findings in this study, we predicted the human exposure to DON and OTA from fish products through carryover from the feed. Following a comparison with tolerable daily intakes, we found the risk to human health from the consumption of salmon-fed diets containing maximum recommended levels of these toxins to be negligible. ARTICLE HISTORY

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Section: Toxicokinetics Of Donmentioning

confidence: 89%

Section: Toxicokinetics Of Donmentioning

confidence: 99%

Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar)

Bernhoft

Høgåsen

Rosenlund

et al. 2017

Food Additives & Contaminants: Part A

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“…While it is known that DON is more rapidly and efficiently absorbed (55%) in pigs compared to other species and that pigs have limited ability to metabolize DON into less toxic forms (Prelusky et al, 1988;Goyarts and Dänicke, 2006;Wu et al, 2010), the variability in toxicity between individual pigs is not well characterized. During Exp.…”

Section: Discussionmentioning

confidence: 99%

The progression of deoxynivalenol-induced growth suppression in nursery pigs and the potential of an algae-modified montmorillonite clay to mitigate these effects12

Frobose

Erceg

Fowler

et al. 2016

Journal of Animal Science

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Two experiments were conducted to characterize the progression of deoxynivalenol (DON)-induced growth suppression and to investigate algae-modified montmorillonite clay (AMMC) as a means to alleviate the effects of DON in nursery pigs. In both experiments, naturally DON-contaminated wheat was used to produce diets with desired DON levels. In Exp. 1, 280 barrows and gilts (10.0 ± 0.2 kg BW) were used in a 28-d experiment arranged in a 2 × 2 + 1 factorial design with 8 replicates per treatment. The 5 treatments consisted of 2 positive control (PC) diets with DON below detection limits and with or without 0 or 0.50% AMMC and 3 negative control (NC) diets with 5 mg/kg of DON and containing 0, 0.25, or 0.50% AMMC. No DON × AMMC interactions were observed. Overall, pigs fed DON had decreased (P < 0.001) ADG and final BW regardless of AMMC addition. Feeding DON-contaminated diets elicited the most severe depression (P < 0.001) in ADFI and G:F from d 0 to 3, remaining poorer overall (P < 0.01) but lessening in severity as exposure time increased. Pigs fed DON diets had greater (P < 0.05) within pen BW variation (CV) on d 28. Although the addition of 0.50% AMMC to diets restored (P < 0.05) ADFI from d 14 to 21 to levels similar to the PC, no other differences were observed for AMMC inclusion. In Exp. 2, 360 barrows (11.4 ± 0.2 kg BW) were used in a 21-d experiment with 9 dietary treatments arranged in a 3 × 3 factorial design with DON and AMMC inclusion as main effects. There were 8 replicate pens per treatment. Treatments consisted of 3 PC diets without DON, 3 low-DON (1.5 mg/kg DON) NC diets, and 3 high-DON (3 mg/kg DON) NC diets with 0, 0.17, or 0.50% AMMC incorporated at each DON level. No DON × AMMC interactions were observed. As DON level increased, ADG and final BW decreased (quadratic, P < 0.05), driven by decreased (quadratic, P < 0.01) ADFI and poorer (quadratic; P < 0.05) G:F. At both 1.5 and 3 mg/kg DON, reductions in ADG were most marked from d 0 to 7 (15 to 22% lower) and were least distinct from d 14 to 21 (5 to 6% lower). Incorporating AMMC at increasing levels had no effect on ADG, ADFI, G:F, or final BW. Overall, these experiments reinforce DON effects on feed intake but also indicate that the effects of DON on G:F may be more severe than previously thought. Furthermore, some pigs appear to develop tolerance to DON, as effects on ADFI and G:F lessen over time. However, the addition of AMMC did not offset the deleterious effects of DON.

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“…Furthermore, the determined carry over factors are likely to overestimate the actual carry over under practical conditions as feed was not withdrawn from the pigs in the experiment while under practical conditions a withdrawal period of several hours is common practice. Considering the rather short elimination half-life of DON determined in chronically exposed pigs of 6.3 h [23], it can be assumed that residue concentrations are even lower under practical conditions.…”

Section: Discussionmentioning

confidence: 99%

Residues of deoxynivalenol (DON) in pig tissue after feeding mash or pellet diets containing low concentrations

Döll

Dänicke

Valenta

2008

Molecular Nutrition Food Res

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Residues of deoxynivalenol (DON) and its metabolite de-epoxy-DON (DOM) were analyzed in specimens of pigs fed diets containing 0, 25, and 50% contaminated wheat (2.5 mg DON/kg) fed as mash or pellets over the final growing period of 11 wk. Median DON concentrations decreased from bile > kidney > serum > liver = muscle, while DOM was only detected in bile and kidney. Maximum carry over rates were 0.0319 for kidney, 0.0064 for liver, and 0.0043 for muscle, demonstrating that the contribution of animal derived food to the consumers' exposure is very low. The high interindividual variation of DON concentrations in all analyzed specimen of pigs fed diets containing similar concentrations of DON does not allow a diagnostic differentiation of animals fed diets containing DON concentrations of approximately 61% of the guidance level of 0.9 mg DON/kg, and those fed diets containing 137% of this concentration. The different feed forms did not affect residue concentrations in any of the investigated specimens.

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Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig

Cited by 147 publications

References 29 publications

Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar)

Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar)

The progression of deoxynivalenol-induced growth suppression in nursery pigs and the potential of an algae-modified montmorillonite clay to mitigate these effects12

Residues of deoxynivalenol (DON) in pig tissue after feeding mash or pellet diets containing low concentrations

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