Bioavailability Studies of Ketorolac Tromethamine Fast Dissolving Tablets Prepared By Direct Compression Method

Mohamed, M. I.

doi:10.9790/3008-0727378

Cited by 1 publication

(1 citation statement)

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“…Rats were divided into three groups, each group is composed of six rats. The first group was the positive control group where each rat was injected with 0.1 mL of 1% carrageenan suspension in 0.9% saline solution into the sub plantar region of the left hind paw [36] of each animal [37]. Optimized DCN-ODTs were assigned to the second group and Diacerein 1 capsules were assigned to the third group.…”

Section: Plos Onementioning

confidence: 99%

Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug for enhanced dissolution: In-vitro optimization/in-vivo evaluation

et al. 2020

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Diacerein (DCN), a potent anti-inflammatory API used to treat osteoarthritis yet, it suffers from poor water solubility which affects its oral absorption. Unabsorbed colonic DCN is converted into rhein, which is responsible for laxation as a main side effect of DCN treatment. Therefore, in this study orally disintegrating tablets (ODTs) loaded with optimized DCN solid dispersion system were prepared using different co-processed excipients (Prosolv® ODT, Pharmaburst® 500 and F-melt®), aiming to achieve improved solubility, rapid absorption and consequently limited amount of rhein reaching the colon. Prepared ODTs were evaluated for physical characteristics, in-vitro drug release, disintegration and wetting times. Dissolution parameters; dissolution efficiency percent at 10 (DE (10 min)%) and 30 (DE (30 min)%) min and mean dissolution time (MDT) were determined. The optimized ODT showed 1.50 and 1.12 fold increase in DE (10 min)% and DE (30 min)%, respectively and 2 fold decrease in MDT, compared to Diacerein® capsules. In-vivo anti-inflammatory effect of optimized ODT, using rat paw edema revealed significant increase in edema inhibition (p < 0.0465) and promoted onset of action compared to Diacerein® capsules at 0.5 hr. It could be concluded that optimized ODT could be promising for enhanced dissolution and rapid absorption of DCN from the oral cavity.

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Section: Plos Onementioning

confidence: 99%