Biobanking of Patient-Derived Xenografts as a Basis for Translation Research in Oncology

Kiblitskaya, A. A.; Shevchenko, A.; Pandova, Olga V.; Ardzha, Anna Yu.

doi:10.17513/spno.30879

Cited by 3 publications

(1 citation statement)

References 16 publications

(16 reference statements)

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“…obtained from patients with colorectal cancer, BC and other types of malignancies have also demonstrated that tumoroids can be used as a test system to predict clinical response to chemotherapy (Danilova et al, 2021;Yao et al, 2022). A number of researchers question the feasibility of PDX in personalized medicine, particularly for selecting targeted therapy or monitoring tumor response to therapy, as PDX is relatively labour-intensive and time-consuming (Sachs et al, 2018), but PDX biobanks are created and successfully used (Abdirahman, 2020;Kiblitskaya, Shevchenko, Pandova, and Ardzha, 2021).…”

Section: Bioresource Collectionsmentioning

confidence: 99%

Biobanks as an important tool in modern translational oncology

Petersen

Chudakova

Shabalina

et al. 2022

BioComm

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The creation and use of biobanks is an actively growing field that plays an important role in the development of many branches of biotechnology and biomedicine, including oncology and translational medicine. In this review, based on the analysis of more than 80 Russian and foreign publications, we describe the current state of biobanking and its future perspectives. The diversity of biobanking and the problems arising from it, including the limits of applicability to different types of research, as well as the prospects for development are discussed. The role of biobanks in the study of malignant neoplasms, including rare/orphan diseases, and in the development of new diagnostic and therapeutic approaches, personalised medicine and pre-clinical screening studies, are highlighted.

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Section: Bioresource Collectionsmentioning

confidence: 99%

Biobanks as an important tool in modern translational oncology

Petersen

Chudakova

Shabalina

et al. 2022

BioComm

View full text Add to dashboard Cite

show abstract

Methodological aspects of creation of patient-derived tumor xenografts

Гончарова¹,

Shevchenko²,

Dashkova³

et al. 2021

Kazan Med J

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High rates of cancer incidence and mortality from malignant neoplasms remains an urgent health problem. The development of the most effective therapeutic algorithms is required to improve the survival of cancer patients. An important condition for the discovery of new anticancer drugs and their translation into clinical practice involves the ability to model tumor growth, reproduce the characteristics of human disease, and evaluate measurable effects of pharmacological substances in laboratory facilities. Xenograft models established by direct implantation of fresh tumor tissue samples from individual patients into immunodeficient mice are considered suitable for both preclinical trials and for solving fundamental problems in oncology. The review highlights the significance of patient-derived xenograft models as a platform with high predictive value and the prerequisites that make them the preferred tool for research in cancer biology. The most important methodological aspects in the creation of these models are considered. Methods for obtaining and preparing biological tumor samples for xenotransplantation are discussed. The significance of the immune status, as well as the phenotypic and genetic characteristics of recipient animals, is described. The article presents the limitations of animal models associated with their immunodeficiency status and ways to overcome them. The principles for choosing xenotransplantation sites (heterotopic and orthotopic) and their advantages and disadvantages are discussed. In conclusion, we emphasize the need to continue the work on optimizing PDX (Patient-Derived Xenograft) models to overcome their limitations and to obtain the most reliable and valuable research results in oncology.

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Technical suitability of wet or dry processing of a dense rubberized warm asphalt mixture

Rodríguez-Alloza

Giuliani²,

Gallego³

2022

materconstrucc

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Warm mix asphalt (WMA) and crumb rubber modified asphalt in the field of asphalt paving have been demonstrated to be green technologies for producing environmentally friendly pavement. However, limited research has assessed the behaviours of mixtures including both technologies. This study performed research aligned with environmental considerations and sustainability to examine the design and manufacturing of dense asphalt mixtures incorporating a crumb-rubber modifier through a wet or dry process and a specific vegetable additive for WMA technologies. The results indicated that, when rubber is added through a wet process, and a WMA vegetable additive is incorporated, the mixture can be manufactured and compacted at temperatures approximately 25 °C below that of the control mixture, while keeping the mechanical properties within the specifications.

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Biobanking of Patient-Derived Xenografts as a Basis for Translation Research in Oncology

Cited by 3 publications

References 16 publications

Biobanks as an important tool in modern translational oncology

Biobanks as an important tool in modern translational oncology

Methodological aspects of creation of patient-derived tumor xenografts

Technical suitability of wet or dry processing of a dense rubberized warm asphalt mixture

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