“…Furthermore, the strategies for optimization using HRP and RSM have used principally CCD (Ghasempur et al, 2007;Yousefi and Kariminia, 2010;Deyhimi and Nami, 2011). The Doehlert approach has been applied to process design using combinations of fungi and peroxide (Da Re et al, 2010) and for other applications (Zolgharnein et al, 2010), but studies about its application for dye removal using HRP and biomimetics in comparative terms are scarce. A recent review reports on the suitability of Box Behnken and Doehlert optimization designs due to more efficient matrices than CCD.…”