“…Thoroughly, their precise mechanisms of action rely on their reactions to carbonyl groups located in the crosslinks between AGEs, subsequently promoting the spontaneous cleavage of carbon–carbon bonds at physiologic pH [ 175 ]. Likewise, an experimental study demonstrated the efficacy of MnmC, an enzyme involved in bacterial tRNA modification, capable of performing a catalytic reversion of the AGEs carboxyethyl-lysine (CEL) and carboxymethyl-lysine (CML) to lysine’s native structure [ 176 ]. The application of these drugs, mainly alagebrium, in diverse animal models has proven to be helpful in arterial stiffness reduction, blood vessel fibrosis [ 173 , 177 ], the development of atherosclerosis [ 178 ], cardiovascular disease [ 179 ], hypertension [ 180 ], and kidney injury [ 181 ].…”