Female sex workers (FSWs) have been documented to have high rates of sexually transmitted diseases and HIV in many parts of the world. However, little work has been done to characterize the prevalence of these infections along the U.S.-Mexican border, where sexual tourism and culturally sanctioned sex work among nationals is widespread. The objective of this study was to compare differences in background characteristics, HIV risk behaviors, drug use, and sexually transmitted infection/HIV prevalence between FSWs who participated in a behavioral risk intervention in two U.S.-Mexican border cities. Baseline data were collected from March 2004 through September 2005. Data from 295 FSWs were compared between Tijuana and Ciudad (Cd.) Juarez. Among 155 FSWs in Tijuana and 140 in Cd. Juarez, HIV seroprevalence was 4.8% and 4.9%, respectively. FSWs in Cd. Juarez were more likely to test positive for active syphilis (31.3%) compared with Tijuana (11.8%) but did not differ in terms of the prevalence of gonorrhea and chlamydia. FSWs in both sites reported high levels of unprotected sex and use of drugs; however, FSWs in Cd. Juarez were more likely than those in Tijuana to ever have injected drugs (75% vs. 25%, p <.001). Heroin and cocaine use and injection drug use were significantly more common in Cd. Juarez, whereas methamphetamine use was more common in Tijuana. Injection of vitamins was common in both cities. Logistic regression analyses suggested that being younger, working in Cd. Juarez, and using heroin or cocaine were independently associated with active syphilis infection. In Tijuana, methamphetamine use was strongly associated with active syphilis infection. These preliminary results suggest that risk profiles for HIV/sexually transmitted infection among FSWs in these two Mexico-U.S. border cities differ, suggesting a need to tailor interventions to the specific needs in each city.

Electron microscopy and immunohistochemistry have been used to study the structural specializations of astrocyte and Müller glia cells in human retinas. The astrocytes and Müller cells contribute to the formation of the internal limiting membrane, the retina, the blood vessel glial limiting membranes and the glial sheaths of the ganglion cells. Two types of junctions were observed among retinal glial cells. Adherent junctions were found between astrocytes and Müller cells, and between adjacent astrocytes. Gap junctions were only observed between astrocyte processes. These similarities suggest that astrocytes and Müller cells can perform the same functions in human retinas. Finally, the "perivascular astrocyte of Wolter", related only to the blood vessels, was not found. All the retinal astrocytes have the same ultrastructural characteristics, confirming the absence of these astroglial cells in human retinas observed by immunohistochemical techniques.

Diabetes Mellitus (DM) is an inflammatory clinical entity with different mechanisms involved in its physiopathology. Among these, the dysfunction of the gut microbiota stands out. Currently, it is understood that lipid products derived from the gut microbiota are capable of interacting with cells from the immune system and have an immunomodulatory effect. In the presence of dysbiosis, the concentration of lipopolysaccharides (LPS) increases, favoring damage to the intestinal barrier. Furthermore, a pro-inflammatory environment prevails, and a state of insulin resistance and hyperglycemia is present. Conversely, during eubiosis, the production of short-chain fatty acids (SCFA) is fundamental for the maintenance of the integrity of the intestinal barrier as well as for immunogenic tolerance and appetite/satiety perception, leading to a protective effect. Additionally, it has been demonstrated that alterations or dysregulation of the gut microbiota can be reversed by modifying the eating habits of the patients or with the administration of prebiotics, probiotics, and symbiotics. Similarly, different studies have demonstrated that drugs like Metformin are capable of modifying the composition of the gut microbiota, promoting changes in the biosynthesis of LPS, and the metabolism of SCFA.

Cell suppression is a widely used technique for protecting sensitive information in statistical data presented in tabular form. Previous works on the subject mainly concentrate on 2- and 3-dimensional tables whose entries are subject to marginal totals. In this paper we address the problem of protecting sensitive data in a statistical table whose entries are linked by a generic system of linear constraints. This very general setting covers, among others, k-dimensional tables with marginals as well as the so-called hierarchical and linked tables that are very often used nowadays for disseminating statistical data. In particular, we address the optimization problem known in the literature as the (secondary) Cell Suppression Problem, in which the information loss due to suppression has to be minimized. We introduce a new integer linear programming model and outline an enumerative algorithm for its exact solution. The algorithm can also be used as a heuristic procedure to find near-optimal solutions. Extensive computational results on a test-bed of 1,160 real-world and randomly generated instances are presented, showing the effectiveness of the approach. In particular, we were able to solve to proven optimality 4-dimensional tables with marginals as well as linked tables of reasonable size (to our knowledge, tables of this kind were never solved optimally by previous authors).Statistical Disclosure Control, Confidentiality, Cell Suppression, Integer Linear Programming, Tabular Data, Branch-and-Cut Algorithms

The goals of the current study were to: (1) estimate the prevalence of forced sex among women accessing services at a women's health clinic in rural Haiti; and (2) examine factors associated with forced sex in this population. Based on data from a case-control study of risk factors for sexually transmitted diseases (STDs), a cross-sectional analysis to examine factors associated with forced sex was performed. A number of factors related to gender inequality/socioeconomic vulnerability placed women in rural Haiti at higher risk of forced sex. The strongest factors associated with forced sex in multivariate analyses were: age, length of time in a relationship, occupation of the woman's partner, STD-related symptoms, and factors demonstrating economic vulnerability. The findings suggest that prevention efforts must go beyond provision of information and education to the pursuit of broader initiatives at both local and national levels. At the community level, policy-makers should consider advancing economic opportunities for women who are vulnerable to forced sex. Improving access to community-based income-generating activities may begin to address this problem. However, the viability of these local projects depends largely upon Haiti's 'macro-economic' situation. In order to ensure the success of local initiatives, external humanitarian and development assistance to Haiti should be supported. By broadening the definition of "prevention" interventions, we may begin to address the systemic problems that contribute to the occurrence of forced sex and the increasing incidence of HIV infection throughout the world, such as gender inequality and economic vulnerability. Taking into account factors influencing risk at the local level as well as the macro-level will potentially improve our capacity to reduce the risk of forced sex and the spread of STDs, including HIV infection, for millions of women living in poverty worldwide.