Biocatalytic synthesis of panthenyl monoacyl esters in ionic liquids and deep eutectic solvents

Lozano, Pedro; Álvarez, Elena; Nieto, Susana; Villa, Rocío; Bernal, Juan Manuel Zaragoza; Donaire, Antonio

doi:10.1039/c9gc01076a

Cited by 32 publications

(24 citation statements)

References 24 publications

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“…Ultrasonic irradiation has recently emerged as a sustainable tool for activating the enzymes, because of the increase in product yield and faster reaction rates under mild frequency conditions [24] . Furthermore, as ultrasound pulses often save energy and provide cleaner products with little or no by-products, the technique can also be considered as “green” [25] . The application of ultrasound agitation for the lipase-catalysed esterification of fructose, glucose, or xylitol in reaction media based on ILs or t-butanol improved the enzyme activity by shortening reaction times (see Entries 11–13; Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-assisted enzymatic synthesis of xylitol fatty acid esters in solvent-free conditions

Nieto

Villa

Donaire

et al. 2021

Ultrasonics Sonochemistry

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Section: Introductionmentioning

confidence: 99%

Ultrasound-assisted enzymatic synthesis of xylitol fatty acid esters in solvent-free conditions

Nieto

Villa

Donaire

et al. 2021

Ultrasonics Sonochemistry

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“…Lipases are common components of ILe enzyme systems. Such reactions include surfactant synthesis [23], food and medicinal applications [24], ester synthesis [25], biodiesel preparation [26], Network visualization of keywords from the Scopus database (2018-2020) for the search terms 'ionic liquids' and 'enzyme,' as of July 20, 2020.…”

Section: Current Developments In Enzymatic Reactions In Ilsmentioning

confidence: 99%

Facilitating enzymatic reactions by using ionic liquids: A mini review

Elgharbawy

Moniruzzaman

Goto

2021

Current Opinion in Green and Sustainable Chemistry

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Over the past two decades, ionic liquids (ILs) have been widely used for enzymatic conversions of substratesespecially substrates that are insoluble in common organic solvents and waterresulting in high conversion rates, high selectivity, and improved enzyme stability, wherein the ILs are recoverable and recyclable. Compared with performance in first-generation ILs, researchers recently considerably improved the technological utility of enzymes in second-and third-generation ILs composed of enzyme-benign cations and anions. Use of upgraded ILs with enzymes offers further improved activity and stability compared with research studies in the past decade, rendering IL-assisted biocatalytic processes more environmentally and economically attractive. This short review briefly presents recent developments of enzymatic reactions in ILs. The review covers approaches for and modifications of enzymes and ILs within the past 2 years for improved enzymes performance in ILs.

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“…This reaction can be performed using biocatalysts (enzymatic technology [ENZ]), without any catalyst (autocatalytic esteri cation [AUT]), or using chemical catalysts (chemical technology [CHEM]) (Abdelmoez and Mustafa, 2014). The key obstacle in the synthesis of monoglycerides is the separation of contaminants due to free glycerol and various concentrations of diglycerides and triglycerides ordinarily present with monoglycerides (Lozano et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Cleaner and Sustainable Synthesis of High Quality Monoglycerides by use of Enzyme Technologies: Techno-economic and Environmental study for Monolaurin

Mustafa

Fathy

Kutlu

et al. 2022

Preprint

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Currently, monoglycerides (MG) are produced using a complicated energy intensive technology that contributes negatively toward greenhouse gas mitigation. This work suggests a cleaner and simpler one-step enzymatic production of α-monolaurin in an inert membrane reactor, where the reaction and enzyme separation are conducted simultaneously in one unit. Candida antarctica lipase (Lipozyme 435) was used to catalyze the esterification reaction between lauric acid and glycerin in a solvent-free system under mild temperatures. Response surface methodology was used to optimize the reaction conditions. The optimal conditions were a molecular sieve of 14.85% w/w, a temperature of 56.95°C, an enzyme amount of 5.38% w/w, and a molar ratio of 4.75% w/w. The gas chromatography (GC) analysis showed that the α-monolaurin percentage was 49.5% when the enzymatic process (ENZ) was used. The conventional chemical (CHEM) and autocatalytic (AUT) esterification methods were also performed to study their proportional MG yields. The GC results showed the MG percentages of 43.9% and 41.7% for CHEM and AUT, respectively. Economic analysis was also conducted for the suggested enzymatic technique, and the findings were compared with those of the CHEM and AUT technologies. Using a plant capacity of 4950 t/year and 11% interest for the proposed ENZ process, the total capital investment of α-monolaurin production was preferably four times less than that of the CHEM process and three times less than that of the AUT method, presenting investment possibilities. However, the ENZ process showed the least profitability (net profit per day) among the three processes. Nevertheless, the return on investment and net present value for the ENZ process were preferably higher than those of CHEM and AUT because of its interestingly lower inside battery limit plant cost and less energy consumption. The AUT/CHEM processes generated a total carbon dioxide (CO2) exhaust of t CO2 678.7 eq./year. In contrast, the ENZ process exhausted a total CO2 of only 50 t CO2 eq./year. The present integrated techno-economic and environmental study of α-monolaurin production emphasizes the green and cost benefits of the proposed ENZ technology.

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Biocatalytic synthesis of panthenyl monoacyl esters in ionic liquids and deep eutectic solvents

Cited by 32 publications

References 24 publications

Ultrasound-assisted enzymatic synthesis of xylitol fatty acid esters in solvent-free conditions

Ultrasound-assisted enzymatic synthesis of xylitol fatty acid esters in solvent-free conditions

Facilitating enzymatic reactions by using ionic liquids: A mini review

Cleaner and Sustainable Synthesis of High Quality Monoglycerides by use of Enzyme Technologies: Techno-economic and Environmental study for Monolaurin

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