Biocellulose Membranes as Supports for Dermal Release of Lidocaine

Abstract

Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTIR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.

Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

“…BC and BC-Gly membranes were considered in this study, since glycerin is normally used as a plasticizer, to increase malleability, as well as the swelling (by promoting water holding and retention) of topical delivery systems [7,8]. Fig.…”

“…Another critical issue regarding the use of topical semisolid formulations is the loss of material due to contact with garments or surfaces [8]. Regarding dose accuracy, for semisolids, the amount of drug used and application area are patient-dependent and therefore are not accurate and vary widely with the patient perception.…”

“…Moreover, the peculiar nanofibrillar structure of BC should represent a suitable macromolecular support for inclusion of drugs and therefore for the development of specific controlled release systems. Previous studies documented the ability of BC membranes to modulate the release and bioavailability of model drugs for percutaneous administration [7,8], and hence, they were proposed as supports for topical or transdermal drug delivery. Therapeutic feasibility is dependent on the skin compatibility of these supports; however, little information is available concerning the skin compatibility and irritation potential of BC-based biomaterials.…”

Antimicrobial functionalization of bacterial nanocellulose by loading with polihexanide and povidone-iodine

“…However, the function of BNC can be improved by inclusion of active substances into the biopolymer. For example, low molecular drugs like anesthetics, analgetics, and beta-blockers as well as metal ions, such as silver, or proteins are used in combination with BNC hydrogels for the preparation of drug delivery systems [10][11][12][13][14][15]. Silver in form of ions or nanoparticles is the active substance applied mainly [10,16,17].…”

Preliminary study on biosynthesis and characterization of bacteria cellulose films from coconut water

“…Applications of bacterial cellulose are extensive in many industries, such as in biomedical industries, paper production, food industries, and cosmetics. In the field of biomedical industries, bacterial cellulose can be used as biosensor, biofill, transdermal drug delivery, and wound cover [9,10,11]. In paper making, bacterial cellulose is used in the production of synthetic paper, insulation materials, and surface coatings.…”