Bioceramic Nanofibres by Electrospinning

Balu, Rajkamal; Singaravelu, Sivakumar; Nagiah, Naveen

doi:10.3390/fib2030221

Cited by 17 publications

(5 citation statements)

References 104 publications

(107 reference statements)

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“…Recently, a new technique has been introduced, which is called electrospinning, and allows the preparation of thin fibrous membranes [ 11 ]. Electrospinning makes use of a high electric voltage to draw polymer solutions/melts into a whipped jet, which becomes ultrafine fibers after drying in air [ 12 ]. Fibers obtained from electrospinning are in the range of 50 nm to a few microns in diameter and generally collected in the form of a non-woven structure [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and In Vitro Characterization of Bioactive Glass/Nano Hydroxyapatite Reinforced Electrospun Poly(ε-Caprolactone) Composite Membranes for Guided Tissue Regeneration

Sunandhakumari

Vidhyadharan²,

Alim

et al. 2018

Bioengineering

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Background: Current resorbable and non-resorbable membranes act as a physical barrier to avoid connective and epithelial tissue downgrowth into the defect, favoring the regeneration of periodontal tissues. These conventional membranes possess many structural and bio-functional limitations. We hypothesized that the next-generation of guided tissue regeneration (GTR) membranes for periodontal tissue engineering will be a biologically active, spatially designed nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). Methods: GTR membranes made of poly(ε-Caprolactone) with a molecular weight of 80,000 reinforced with different weight concentrations of nano-Hydroxyapatite/Bioactive glass (2%, 5%, 10%, 15%) is fabricated by the method of electrospinning. After fabrication, in vitro properties are evaluated. Results: The electrospun nanofibrous membranes possessed excellent mechanical properties initially and after one month of degradation in phosphate buffer solution (PBS). Moreover, none of the fabricated membranes were found to be cytotoxic at lower concentrations and higher concentrations. Comparing the overall properties, PCL (poly(e-caprolactone)) + BG (Bioactive glass) 2% exhibited superior cell attachment and percentage of viable cells, increased fiber and pore diameter which satisfies the ideal properties needed for GTR membranes. Conclusion: Composite nanofibrous membranes prepared by electrospinning are suitable for use as a GTR membrane and are a useful prototype for further development of a final membrane for clinical use.

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Section: Introductionmentioning

confidence: 99%

Fabrication and In Vitro Characterization of Bioactive Glass/Nano Hydroxyapatite Reinforced Electrospun Poly(ε-Caprolactone) Composite Membranes for Guided Tissue Regeneration

Sunandhakumari

Vidhyadharan²,

Alim

et al. 2018

Bioengineering

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“…Furthermore, bioceramics can be electrospun either as a sol− gel or as a composite with a polymer in solution. 179 A number of new studies have utilized electrospinning to prepare instructive osteochondral scaffolds that span from the articular cartilage to the cancellous bone. 176,180 Most often, these scaffolds have been formed by combining individually prepared, discrete electrospun layers using solvent-bonding, freeze-drying, or other methods.…”

Section: ■ Considerations Formentioning

confidence: 99%

“…Utilization of magnetically responsive polymers affords the opportunity for magnetically assisted fabrication, in which fibers can be aligned with direction of an applied magnetic field. , Electrospinning is a versatile fabrication technique suitable for many polymers, including synthetic and natural polymers and combinations of the two. Furthermore, bioceramics can be electrospun either as a sol–gel or as a composite with a polymer in solution …”

Section: Materials-guided Tissue Engineering Approachesclinical Trialsmentioning

confidence: 99%

Perspectives on Synthetic Materials to Guide Tissue Regeneration for Osteochondral Defect Repair

Frassica

Grunlan

2020

ACS Biomater. Sci. Eng.

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Regenerative engineering holds the potential to treat clinically pervasive osteochondral defects (OCDs). In a synthetic materials-guided approach, the scaffold’s chemical and physical properties alone instruct cellular behavior in order to effect regeneration, referred to herein as “instructive” properties. While this alleviates the costs and off-target risks associated with exogenous growth factors, the scaffold must be potently instructive to achieve tissue growth. Moreover, toward achieving functionality, such a scaffold should also recapitulate the spatial complexity of the osteochondral tissues. Thus, in addition to the regeneration of the articular cartilage and underlying cancellous bone, the complex osteochondral interface, composed of calcified cartilage and subchondral bone, should also be restored. In this Perspective, we highlight recent synthetic-based, instructive osteochondral scaffolds that have leveraged new material chemistries as well as innovative fabrication strategies. In particular, scaffolds with spatially complex chemical and morphological features have been prepared with electrospinning, solvent-casting–particulate-leaching, freeze-drying, and additive manufacturing. While few synthetic scaffolds have advanced to clinical studies to treat OCDs, these recent efforts point to the promising use of the chemical and physical properties of synthetic materials for regeneration of osteochondral tissues.

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“…Alumina (Al 2 O 3 ) is a bio-inert ceramic that possesses unique properties, such as high abrasion resistance, biocompatibility, and chemical inertness [ 160 ]. Hollow alumina nanofibers prepared via single-spinneret electrospinning and sintering have been studied by Peng et al [ 124 ].…”

Section: Most Studied Ceramic Hollow Nanofibers and Their Applicatmentioning

confidence: 99%

The Electrospun Ceramic Hollow Nanofibers

et al. 2017

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Hollow nanofibers are largely gaining interest from the scientific community for diverse applications in the fields of sensing, energy, health, and environment. The main reasons are: their extensive surface area that increases the possibilities of engineering, their larger accessible active area, their porosity, and their sensitivity. In particular, semiconductor ceramic hollow nanofibers show greater space charge modulation depth, higher electronic transport properties, and shorter ion or electron diffusion length (e.g., for an enhanced charging–discharging rate). In this review, we discuss and introduce the latest developments of ceramic hollow nanofiber materials in terms of synthesis approaches. Particularly, electrospinning derivatives will be highlighted. The electrospun ceramic hollow nanofibers will be reviewed with respect to their most widely studied components, i.e., metal oxides. These nanostructures have been mainly suggested for energy and environmental remediation. Despite the various advantages of such one dimensional (1D) nanostructures, their fabrication strategies need to be improved to increase their practical use. The domain of nanofabrication is still advancing, and its predictable shortcomings and bottlenecks must be identified and addressed. Inconsistency of the hollow nanostructure with regard to their composition and dimensions could be one of such challenges. Moreover, their poor scalability hinders their wide applicability for commercialization and industrial use.

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Bioceramic Nanofibres by Electrospinning

Cited by 17 publications

References 104 publications

Fabrication and In Vitro Characterization of Bioactive Glass/Nano Hydroxyapatite Reinforced Electrospun Poly(ε-Caprolactone) Composite Membranes for Guided Tissue Regeneration

Fabrication and In Vitro Characterization of Bioactive Glass/Nano Hydroxyapatite Reinforced Electrospun Poly(ε-Caprolactone) Composite Membranes for Guided Tissue Regeneration

Perspectives on Synthetic Materials to Guide Tissue Regeneration for Osteochondral Defect Repair

The Electrospun Ceramic Hollow Nanofibers

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