Biochemical activation and functions of drug-metabolizing enzymes

Shabbir, Anam; Haider, Kamran; Rehman, Kanwal; Akash, Muhammad Sajid Hamid; Chen, Shuqing

doi:10.1016/b978-0-323-95120-3.00021-x

Cited by 4 publications

(5 citation statements)

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“…359 In addition to their detoxication role, GSTs have isomerase and peroxidase functions and can bind to numerous endogenous substances and exogenous ligands. 360,361 Transglutaminase (TGM) enzymes are a subgroup of transferase enzymes. Transglutaminases (TGMs) facilitate intramolecular and intermolecular cross-links between glutamine and lysine residues, with the former serving as acyl donors and the latter as acyl acceptors.…”

Section: Transferasesmentioning

confidence: 99%

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Advancements in enzyme immobilization on magnetic nanomaterials: toward sustainable industrial applications

Gama Cavalcante,

Dari,

Izaias da Silva Aires

et al. 2024

RSC Adv.

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Section: Transferasesmentioning

confidence: 99%

“…359 In addition to their detoxification role, GSTs have isomerase and peroxidase functions and can bind to numerous endogenous substances and exogenous ligands. 360,361…”

Section: Enzymatic Magnetic Nanoparticle Applicationsmentioning

confidence: 99%

Advancements in enzyme immobilization on magnetic nanomaterials: toward sustainable industrial applications

Gama Cavalcante,

Dari,

Izaias da Silva Aires

et al. 2024

RSC Adv.

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“…The metabolism and elimination of drugs also play a crucial role in their overall activity and therapeutic duration. NPs can impact drug metabolism by modulating the activity of drug-metabolizing enzymes and transporters in the liver and other organs [113,114]. By improving drug metabolism and elimination, nanoparticle-based delivery systems contribute to the maintenance of optimal drug levels, prolonged drug activity, and improved therapeutic outcomes [115].…”

Section: Metabolismmentioning

confidence: 99%

Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

et al. 2023

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Breast cancer is a major cause of death globally, accounting for around 13% of all deaths. Chemotherapy, the common treatment for cancer, can have side effects that lead to the production of reactive oxygen species (ROS) and an increase in oxidative stress in the body. Antioxidants are important for maintaining the health of cells and helping the immune system function properly. They play a crucial role in balancing the body’s internal environment. Using natural antioxidants is an alternative to mitigate the harmful effects of oxidative stress. However, around 80% of natural antioxidants have limited effectiveness when taken orally because they do not dissolve well in water or other solvents. This poor solubility affects their ability to be absorbed by the body and limits their bioavailability. One strategy that has been considered is to increase their water solubility to increase their oral bioavailability. Chitosan-based nanoparticle (CSNP) systems have been extensively explored due to their reliability and simpler synthesis routes. This review focuses on the various methods of chitosan-based nanoformulation for developing effective oral dosage forms for natural antioxidants based on the pharmacokinetics and pharmacodynamics properties. Chitosan (CS) could be a model, because of its wide use in polymeric NPs research, thus providing a better understanding of the role of vehicles that carry natural antioxidants in maintaining the stability and enhancing the performance of cancer drugs.

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“…These enzymatic reactions play a significant role in the creation of pharmaceutical compounds with desired stereochemical properties and targeted biological activities. [151][152][153][154] These enzymes are utilized in several industries and for the synthesizing fine chemicals and pharmaceuticals few of which are discussed below.…”

Section: L-ascorbyl Palmitatementioning

confidence: 99%