Biochemical alteration in some Iraqi children with autistic spectrum disorder (ASD)

Abstract

Background: Autism spectrum disorder (ASD) is a general term for a group of complex disorders of brain development; these disorders have no single known cause, they are characterized, in varying degrees, by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors. Objective: The aim of the study was to evaluate different biochemical parameters in some autistic Iraqi children, and to compare the results with healthy children who matched with age, looking for any alteration in the studied parameters in order to understand the biochemistry of this disorder. Patients and Methods: Forty one consecutive autistic children admitted to (Al Safa center for autism and Iben-AL Rshid Psychiatry Teaching Hospital) were included in the current study with mean age of (6.62y±3). Results: Results obtained in the present study were higher significantly high levels (p≤0.05) of serum uric acid, serum total bilirubin, and thyroid stimulating hormone (TSH). While non-significant differences (p≥0.05) in the levels of fasting blood glucose, total cholesterol, serum totals protein, serum albumin, and total thyroxine T4, triiodothyronine T3. The results also indicated three cases of autistic children who have positive test for serum Anti-tissue-transglutaminase IgA & IgG antibody by using ELISA technique. Conclusion: The present study highlights the relationship between some chemical parameters and ASD. Further study must carry out with large number of cases to investigate this relationship more deeply in these patients.

A Study of Some Biochemical Indicators of Kidney Function and Estimation of Some Elements Concentration in the Blood Serum of Patients With Celiac Disease

“…The results in Table (4) showed a significant decrease in Fe, Cu, Ca , and Zn in the patients eating gluten compared with the healthy subjects at a probability level (p ≤ 0.05), as well as a significant decrease in Fe, Cu, Ca and Zn elements in Patients abstaining from eating gluten compared to healthy subjects at a probability level (p 0.05). The results in Table (5) showed a significant decrease in iron, and no significant difference in copper, calcium and zinc among healthy subjects whose age group ranged between (2-12) years compared with healthy subjects whose age group ranged between (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) year at a probability level (p 0.05).…”

“…Although celiac is known as an injury to the small intestine and results in malnutrition, in recent times this disease has been characterized as a disorder that occurs in the function of many systems in the human body, also the incidence of mental illness, depression and infertility is increased in patients with celiac disease [3] . In another study conducted on autistic patients in Iraq, it was found that three of the autistic cases also have celiac disease [4] The kidneys work to get rid of excess fluids and waste products through the urine, and to maintain a balance of salts in the blood, and to control blood pressure and regulate some of hormonal functions such as erythropoietin, activation of vitamin D [5] . There is a relationship between celiac disease and kidney disease , In one study conducted on 827 kidney patients, it showed that 54 of them had celiac disease [6].…”