To date, the waste-to-wealth concept is a common aptitude in the world (Varzakas et al., 2016). The food and agricultural industries all over the world produce a large number of wastes after using the whole fruit, which contains significant amounts of bioactive or functional components, sugar, and dietary fiber (Madhumeena et al., 2021). The utilization of these wastes has become a main concern and challenging aspect because of the higher production of by-products (peels, seeds, leaves, stems, roots, and pomace) during several stages of the processing chain (Mármol et al., 2021). Studies have validated the waste utilization process as a novel, less expensive, economical, and alternative source of food additives, antioxidants, pectin, and organic acids through various extractions and fermentation methods (Roda & Lambri, 2019). In this case, based on recent studies, fruit-by-products have been suggested as an alternative vehicle for probiotic production (Roda & Lambri, 2019;Ruiz Rodríguez et al., 2021).Pineapple, watermelon, and banana are popular tropical fruits in the world; their production per year worldwide was 18.8, 81.2, and 116 million tons, respectively (FAO, 2020;Yang et al., 2016). Their by-products are a rich source of nutritional components, which make them the best suitable candidate to produce new value-added products (Ahmadi & Ganjidoust, 2021;Vicenssuto & de Castro, 2020).The demand for the efficient use of food by-products has increased due to economic and environmental concerns (Yang et al., 2010).According to Food and Agriculture Organization and the World Health Organization (FAO/WHO, 2001), probiotics are "live microorganisms when administered in adequate amounts confer a health benefit on the host". The Coronavirus Disease (COVID-19), which