Biochemical analysis of the metabolism of small rodents living in different radioecological conditions

Orekhova, N. A.; Rasina, L. N.

doi:10.15298/rusjtheriol.11.1.02

Cited by 4 publications

(2 citation statements)

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“…[14]. At the same time, biochemical changes [15] and morphological variation of the skull of mole vole are associated with the level of 90 Sr accumulation in the skeleton [33]. Results of the study of allozyme variability in the population of EURT rodents [16] provide new data for the discussion about the mechanism of the effects of radiation.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of radiation exposure of murine rodents at the EURT territories

et al. 2014

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The study provides data on contemporary levels of radiation exposure of organs and tissues of murine rodents (several species of mice and voles) inhabiting the East-Ural Radioactive Trace. The estimation procedure involves the most advanced approach based on application of appropriate voxel phantom and biokinetic model. Input data for dose assessment are the results of measurements of skeletal 90Sr activity concentration. Maximal internal dose to skeleton, accumulated during 45 days, is 303 mGy. Median internal dose rates on the last day before trapping were 0.83, 0.092 and 0.023 mGy/day for animals trapped at the sites with initial (1957) 90Sr surface contamination >37 MBq/m2, 18.5–37 MBq/m2 and 0.074–18.5 MBq/m2 respectively. Taking to account internal and external exposures, upper boundary of the ICRP Derived Consideration Reference Level (DCRL) is exceeded on the territory with maximal level of the initial 90Sr surface contamination. On the territory with 18.5–37 MBq/m2, whole body mean dose rates to murine rodents exceed the lower boundary of DCRL. On the areas with lower level of surface contamination, even the 90-th percentile of dose rate is below the DCRL.

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Section: Discussionmentioning

confidence: 99%

“…Estimates of doses and effects of irradiation on plants are presented in [3,4]. Among other animals, the murine rodents are the most studied [5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Assessment of radiation exposure of murine rodents at the EURT territories

et al. 2014

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Hematological indicators in pygmy wood mouse Apodemus uralensis (Muridae, Rodentia) populations as markers of the environmental radiation exposure: East Urals radioactive trace (Russia)

Orekhova

2018

Environ Sci Pollut Res

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The hematological effects of chronic radiation exposure in males of the pygmy wood mouse (Apodemus uralensis Pall., 1811) from the East Urals radioactive trace (EURT) area were assessed, taking into account population abundance and reproductive status (immature, ripening, and mature yearlings). For this purpose, we analyzed the morpho-functional characteristics of erythrocytes (red cell indices [MCV, MCH, MCHC], red cell count, activity of antioxidant enzymes [GSH-Px, CAT], lipid peroxidation, glycolysis, osmotic resistance, methaemoglobin content) and blood plasma components (free hemoglobin, total lipids, total cholesterol, and glucose) in the background territory and the EURT area; these areas have a density of soil contamination with Sr of 12,851 and 198 kBq × m, respectively (four and two order of magnitude higher than the background value). The data indicate the "hyperfunctional" state of the erythrocyte, aimed at activation of the gas transport function of blood in the radioactive environment. This, as a consequence, determines the insufficiency of energy supply of the cell defense system necessary to maintain the structural integrity of the membrane. Intensification of membrane lipid peroxidation, reduction of osmotic resistance and GSH-Px activity in red cells, an increase in the degree of intravascular hemolysis, and tendency towards erythropenia indicate the processes of accelerated aging of erythrocytes and their more pronounced destruction in the circulatory bed. The level of the hematological response increased with increasing radiation burden and was more pronounced with a large population size. The interaction effect of "overpopulation" and "radioactive pollution" was observed to a lesser degree for ripening males, and was very small for sexually mature animals. Immature males from the EURT head part with internal whole-body radiation doses of 0.0045-0.35 mGy/day can be considered as the most sensitive group to the factors synergy, including radiation damage and overabundance population.

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Contemporary radiation doses to murine rodents inhabiting the most contaminated part of the EURT

Malinovsky

Yarmoshenko

Zhukovsky

et al. 2014

Journal of Environmental Radioactivity

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Biochemical analysis of the metabolism of small rodents living in different radioecological conditions

Abstract: ÊËÞ×ÅÂÛÅ ÑËÎÂÀ: ìåëêèå ãðûçóíû, çîíà ÂÓÐÑà, ôóíêöèîíàëüíî-ìåòàáîëè÷åñêèå èçìåíåíèÿ, ñòðàòåãèè ôèçèîëîãè÷åñêîé àäàïòàöèè.

Cited by 4 publications

References 20 publications

Assessment of radiation exposure of murine rodents at the EURT territories

Assessment of radiation exposure of murine rodents at the EURT territories

Hematological indicators in pygmy wood mouse Apodemus uralensis (Muridae, Rodentia) populations as markers of the environmental radiation exposure: East Urals radioactive trace (Russia)

Contemporary radiation doses to murine rodents inhabiting the most contaminated part of the EURT

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