Biochemical and cytologic analysis of cystic contents in benign non‐parasitic symptomatic hepatic cysts before and after ethanol sclerotherapy

Larssen, Trond Bjerke; Rørvik, Jarle; Horn, Arild; Karwinski, B.; Skadberg, Øyvind; Pedersen, Ole Martin; Rosendahl, Karen

doi:10.1080/02841850410006588

Cited by 14 publications

(12 citation statements)

References 16 publications

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“…Repeated aspirations may be required to achieve complete cyst regression. Analysis of postsclerotherapy cyst fluid has revealed a marked inflammatory reaction [22], which has been postulated as being the main mechanism by which cysts are obliterated. Hepatic cyst communication with the biliary system and malignancy are contraindications to sclerotherapy treatment.…”

Section: Discussionmentioning

confidence: 99%

Nine-Year Single-Center Experience with Nonparastic Liver Cysts: Diagnosis and Management

et al. 2006

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This study presents the experience with laparoscopic deroofing of nonparasitic liver cysts at a single center over a 9-year period. A total of 25 patients, undergoing 32 operations, were identified. Median cyst diameter was 10 cm for de novo cysts and 9.5 cm for recurrent cysts. Six patients had multiple cysts consistent with polycystic liver disease. In total, there were 26 laparoscopic procedures and 2 open conversions. Four procedures were commenced as open, three of which were for recurrent cysts. Minor complications were bleeding from a port site (n=1), pneumothorax (n=2), and intra-abdominal collection (n=1). One major complication of bile leak and relaparotomy occurred following an open deroofing. No major complications were recorded for laparoscopic procedures. Symptomatic recurrence of cysts occurred in four patients with simple cysts (5%) and one patient with polycystic liver disease. We conclude that laparoscopic liver cyst deroofing is an effective method of dealing with symptomatic nonparasitic liver cysts.

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Section: Discussionmentioning

confidence: 99%

Nine-Year Single-Center Experience with Nonparastic Liver Cysts: Diagnosis and Management

et al. 2006

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“…Vormittag et al [15] proved that Hp2-2 was a potentially new risk factor for spontaneous venous thromboembolism as well. There are many researches about Hp correlate with injury, inflammation, metabolic disease [16–18]. More and more documents report that the level of Hp in plasmas goes up in many malignant tumors, such as ovarian cancer [19], breast cancer [20], renal cell cancer [21], colon carcinoma [22], acute leukemia [23], and lung cancer [24].…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of Serum in Lung Cancer Induced by 3‐Methylcholanthrene

Zhang

et al. 2009

BioMed Research International

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Lung cancer remains the leading cause of cancer-related mortality worldwide. Early detection of lung cancer is problematic due to the lack of a marker with high diagnosis sensitivity and specificity. To determine the differently expressed proteins in the serum of lung cancer and figure out the function of the proteins, two-dimensional electrophoresis (2DE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) were used to screen the serum proteins of lung cancer model induced by 3-methylcholanthrene (MCA). From optimized 2DE image, 455 spots in the normal sera and 716 spots in the lung cancers sera were detected. Among them, 141 protein spots were differentially expressed when comparing the serum from normal rat and serum from lung cancer model, including 82 overexpressed proteins and 59 underexpressed proteins. Changes of haptoglobin, transthyretin, and TNF superfamily member 8 (TNFRS8) were confirmed in sera from lung cancer by MALDI-TOF-MS. Proteomics technology leads to identify changes of haptoglobin, transthyretin, and TNFRS8 in serum of rat lung cancer model and represents a powerful tool in searching for candidate proteins as biomarkers.

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“…Alcohol can also induce a temporary inflammatory reaction in a cystic wall deprived of vital epithelium [28]. This may explain the transitory re-accumulation of cyst fluid seen in the present and other studies [5, 6].…”

Section: Discussionmentioning

confidence: 54%

Single-session alcohol sclerotherapy of symptomatic liver cysts using 10–20 min of ethanol exposure: no recurrence at 2–16 years of follow-up

et al. 2016

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PurposeTo assess long-term results after single-session alcohol sclerotherapy of symptomatic benign liver cysts performed with maximum 20 min of exposure to alcohol.MethodsWe included 47 patients aged 32–88 years (42 women, 5 men) with 51 benign non-parasitic liver cysts that were exposed to ethanol for 7–20 min in a single sclerotherapy session and were followed for at least 24 months. Each cyst was emptied before injecting ethanol (10% of cyst volume, but maximum 100 mL) into it. The patient rotated from side to side to facilitate contact between ethanol and the whole cyst wall. Pre-treatment cyst volume was defined as the volume of aspirated cyst fluid after complete emptying of the cyst. Follow-up cyst volume was estimated based on computed tomography images.ResultsCyst volumes were 30–4900 (median 520) mL at pre-treatment and 0–230 (median 1) mL at 24–193 (median 56) months follow-up, a reduction of 83–100% (median 99.7%). No cyst required repeated treatment during the follow-up. Median volume reduction was 99.7% at median 49 months of follow-up for 35 cysts exposed to ethanol for 7–10 min vs. 99.6% at median 75 months of follow-up for 16 cysts exposed for 20 min (p = 0.83, Mann–Whitney test). Ethanol intoxication occurred in one patient. There were no other complications except for pain.ConclusionLong-term results of single-session alcohol sclerotherapy performed with maximum 20 min of exposure to ethanol were satisfactory with no sign of recurrence of cyst fluid.

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Biochemical and cytologic analysis of cystic contents in benign non‐parasitic symptomatic hepatic cysts before and after ethanol sclerotherapy

Abstract: The post-sclerotherapy fluid production is probably due to an inflammatory reaction. This may explain the success of performing sclerotherapy in one single session.

Cited by 14 publications

References 16 publications

Nine-Year Single-Center Experience with Nonparastic Liver Cysts: Diagnosis and Management

Nine-Year Single-Center Experience with Nonparastic Liver Cysts: Diagnosis and Management

Proteomic Analysis of Serum in Lung Cancer Induced by 3‐Methylcholanthrene

Single-session alcohol sclerotherapy of symptomatic liver cysts using 10–20 min of ethanol exposure: no recurrence at 2–16 years of follow-up

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