Biochemical and Hematologic Correlates of Alcoholism and Liver Disease

Ryback, Ralph S.

doi:10.1001/jama.1982.03330180021025

Cited by 81 publications

(24 citation statements)

References 17 publications

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“…[22] On step-wise discriminant analysis, emergence of AST as the first variable in correctly identifying alcohol dependents and nondependents with good diagnostic accuracy is in agreement with the literature. [23][24][25] However, Sorenson et al suggested that AST has long-term prognostic value. [23] The GGT levels are elevated in approximately 80% of persons with established alcohol dependence, whereas it is increased in as few as 30% of hazardous drinkers.…”

Section: Discussionmentioning

confidence: 99%

Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis

Vaswani¹,

Rao²

2005

Indian J Med Sci

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Section: Discussionmentioning

confidence: 99%

Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis

Vaswani¹,

Rao²

2005

Indian J Med Sci

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“…This study also found that 2% of patients with clinically suspected ALD alone had concomitant, unsuspected, nonalcoholic liver disease on biopsy, and only 4.6% of patients with a clinical suspicion of nonalcoholic liver disease had histological findings consistent with ALD alone on biopsy. Other data also suggest that a combination of clinical and laboratory data can make an accurate diagnosis of ALD (46,47). In addition, laboratory indices (Prothrombin time, GGT, and apolipoprotein A1) predict the presence of cirrhosis on biopsy and may substitute when biopsy is not possible (48).…”

Section: Liver Biopsy In Alcoholic Liver Diseasementioning

confidence: 99%

Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology

McCullough

O’Connor

1998

American Journal of Gastroenterology

229

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PREAMBLEGuidelines for clinical practice are intended to suggest preferable approaches to particular medical problems as established by interpretation and collation of scientifically valid research, derived from extensive review of published literature. When data are not available that will withstand objective scrutiny, a recommendation may be made based on a consensus of experts. Guidelines are intended to apply to the clinical situation for all physicians without regard to specialty. Guidelines are intended to be flexible, not necessarily indicating the only acceptable approach, and should be distinguished from standards of care that are inflexible and rarely violated. Given the wide range of choices in any health care problem, the physician should select the course best suited to the individual patient and the clinical situation presented.These guidelines are developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee. These guidelines are also approved by the governing boards of the American Gastroenterological Association and the American Association for the Study of Liver Disease. Expert opinion is solicited from the outset for the document. Guidelines are reviewed in depth by the Committee, with participation from experienced clinicians and others in related fields. The final recommendations are based on the data available at the time of the production of the document and may be updated with pertinent scientific developments at a later time.Objective: The objective of this work was to develop practice guidelines for the management of alcoholic liver disease. Method: A computerized search using the Medline Data Base from 1966 -July 1997 was performed with the search headings; alcohol, alcoholic hepatitis, alcoholic liver disease, liver transplant, diagnosis, epidemiology, human, and English only. All randomized controlled trials, case-control studies, and meta-analyses were read in depth. A manual search was also done using references from each retrieved report, review articles, editorials, postgraduate course syllabi, and textbooks. In the subsequent review, evidence was evaluated using a hierarchical scale with randomized, controlled trials given the most importance. Abstracts presented at national meetings were included only when unique data were obtained from those studies. (Am J Gastroenterol 1998;93:2022-2036.

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“…Firstly, in the general population, the correla tion coefficients and predictive values are too low to be of real use, although the test combi nations may have a role in detecting inpa tients who should be questioned further con cerning alcohol consumption [1 16, 117, 119], Secondly, the sensitivities of markers differ Table VII between patients who seem to have different thresholds for the effects of alcohol; the increment for each test varies and the time of return to normal with abstinence varies [120], Biochemical markers have been used to differentiate alcoholic from nonalcoholic liver disease, and to stage the former. Dis criminant analysis of 25 routine laboratory tests assigned 83% of alcoholic and nonalco holic patients to the correct group in a pro spective study [122], Removal of traditional biochemical liver tests had little effect on classification. The AST:ALT ratio identified 75% of the alcoholic patients, but 67% of the nonalcoholic subjects were incorrectly classi fied.…”

Section: Alcohol and Liver Diseasementioning

confidence: 99%

Serum Enzymes and Enzyme Profiles in the Diagnosis of Liver and Biliary Tract Disease

MacNamara¹,

Goldberg²

1985

Dig Dis

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Biochemical and Hematologic Correlates of Alcoholism and Liver Disease

Cited by 81 publications

References 17 publications

Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis

Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis

Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology

Serum Enzymes and Enzyme Profiles in the Diagnosis of Liver and Biliary Tract Disease

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